Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/19364 |
Resumo: | HCPC Latin America Excellence Centre Programme (072405/Z/03/Z) and grant 088862/Z/09/Z; and INCT/MCT/CNPq Programme (Contract no. 5737862008-9). We thank CAPES, CNPq and FAPESB |
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Neves, Neuza Maria AlcantaraVeiga, Rafael ValentePonte, João Carlos MarquesCunha, Sérgio Souza daSimões, Silvia de MagalhãesCruz Filho, Álvaro Augusto Souza daYazdanbakhsh, MariaMatos, Sheila Maria Alvim deSilva, Thiago Magalhães daFigueiredo, Camila APontes-de-Carvalho, Lain CarlosRodrigues, Laura CFiaccone, Rosemeire LeovigildoCooper, Philip JBarreto, Maurício Lima2017-06-12T14:01:00Z2017-06-12T14:01:00Z2017NEVES, N. M. A. et al. Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children. Plos One, 20171932-6203https://www.arca.fiocruz.br/handle/icict/1936410.1371/journal.pone.0174089HCPC Latin America Excellence Centre Programme (072405/Z/03/Z) and grant 088862/Z/09/Z; and INCT/MCT/CNPq Programme (Contract no. 5737862008-9). We thank CAPES, CNPq and FAPESBUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, Brasil / Universidade Federal de Juiz de Fora. Juiz de Fora, MG, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilUniversidade Federal de Pernambuco. Departamento Medicina Social. Recife, PE, BrasilUniversidade Federal de Sergipe. Departamento de Pediatria. Aracaju, SE, BrasilUniversidade Federal da Bahia. ProAR- Núcleo de Excelência em Asma. Salvador, BA, BrasilLeiden University Medical Center da Bahia. Department of Parasitology. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil / Universidade Estadual do Sudoeste da Bahia. Departamento de Ciências Biológicas. Vitória da Conquista, BA, BrasilUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilSt George's University of London. Institute of Infection and Immunity. London, United Kingdom,Universidade Federal da Bahia. Instituto de Matemática. Departamento de Estatística. Salvador, BA, BrasilUniversidad Internacional del Ecuador. Faculty of Facultad de Ciencias Medicas, de la Salud y la Vida. Quito, Ecuador / St George's University of London. Institute of Infection and Immunity. London, United KingdomUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilThe dissociation between specific IgE and skin prick test reactivity to aeroallergens, a common finding in populations living in low and middle-income countries, has important implications for the diagnosis and treatment of allergic diseases. Few studies have investigated the determinants of this dissociation. In the present study, we explored potential factors explaining this dissociation in children living in an urban area of Northeast Brazil, focusing in particular on factors associated with poor hygiene. Methods Of 1445 children from low income communities, investigated for risk factors of allergies, we studied 481 with specific IgE antibodies to any of Blomia tropicalis, Dermatophagoides pteronyssinus, Periplaneta americana and Blatella germanica allergens. Data on demographic, environmental and social exposures were collected by questionnaire; serum IgG and stool examinations were done to detect current or past infections with viral, bacterial, protozoan and intestinal helminth pathogens. We measured atopy by skin prick testing (SPT) and specific IgE (sIgE) to aerollergens in serum (by ImmunoCAP). SIgE reactivity to B. tropicalis extract depleted of carbohydrates was measured by an in-house ELISA. Total IgE was measured by in house capture ELISA. SNPs were typed using Illumina Omni 2.5. Results Negative skin prick tests in the presence of specific IgE antibodies were frequent. Factors independently associated with a reduced frequency of positive skin prick tests were large number of siblings, the presence of IgG to herpes simplex virus, Ascaris lumbricoides and Trichuris trichiura infections, living in neighborhoods with infrequent garbage collection, presence of rodents and cats in the household and sIgE reactivity to glycosylated B. tropicalis allergens. Also, SNP on IGHE (rs61737468) was negatively associated with SPT reactivity. Conclusions A variety of factors were found to be associated with decreased frequency of SPT such as unhygienic living conditions, infections, total IgE, IgE response to glycosylated allergens and genetic polymorphisms, indicating that multiple mechanisms may be involved. Our data, showing that exposures to an unhygienic environment and childhood infections modulate immediate allergen skin test reactivity, provide support for the "hygiene hypothesis".engPublic Library of ScienceTestes cutâneosAlergiaAlergenosMeio ambienteHigieneHumanosCriançasBrazilSkin testAllergyAllergensEnvironmentalHygieneHumansChildrenBrazilTestes cutâneosAlergiaAlergenosMeio ambienteHigieneHumanosCriançasBraziDissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/19364/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNeves NMA Dissociation between....pdfNeves NMA Dissociation 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| dc.title.pt_BR.fl_str_mv |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children |
| title |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children |
| spellingShingle |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children Neves, Neuza Maria Alcantara Testes cutâneos Alergia Alergenos Meio ambiente Higiene Humanos Crianças Brazil Skin test Allergy Allergens Environmental Hygiene Humans Children Brazil Testes cutâneos Alergia Alergenos Meio ambiente Higiene Humanos Crianças Brazi |
| title_short |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children |
| title_full |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children |
| title_fullStr |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children |
| title_full_unstemmed |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children |
| title_sort |
Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children |
| author |
Neves, Neuza Maria Alcantara |
| author_facet |
Neves, Neuza Maria Alcantara Veiga, Rafael Valente Ponte, João Carlos Marques Cunha, Sérgio Souza da Simões, Silvia de Magalhães Cruz Filho, Álvaro Augusto Souza da Yazdanbakhsh, Maria Matos, Sheila Maria Alvim de Silva, Thiago Magalhães da Figueiredo, Camila A Pontes-de-Carvalho, Lain Carlos Rodrigues, Laura C Fiaccone, Rosemeire Leovigildo Cooper, Philip J Barreto, Maurício Lima |
| author_role |
author |
| author2 |
Veiga, Rafael Valente Ponte, João Carlos Marques Cunha, Sérgio Souza da Simões, Silvia de Magalhães Cruz Filho, Álvaro Augusto Souza da Yazdanbakhsh, Maria Matos, Sheila Maria Alvim de Silva, Thiago Magalhães da Figueiredo, Camila A Pontes-de-Carvalho, Lain Carlos Rodrigues, Laura C Fiaccone, Rosemeire Leovigildo Cooper, Philip J Barreto, Maurício Lima |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Neves, Neuza Maria Alcantara Veiga, Rafael Valente Ponte, João Carlos Marques Cunha, Sérgio Souza da Simões, Silvia de Magalhães Cruz Filho, Álvaro Augusto Souza da Yazdanbakhsh, Maria Matos, Sheila Maria Alvim de Silva, Thiago Magalhães da Figueiredo, Camila A Pontes-de-Carvalho, Lain Carlos Rodrigues, Laura C Fiaccone, Rosemeire Leovigildo Cooper, Philip J Barreto, Maurício Lima |
| dc.subject.other.pt_BR.fl_str_mv |
Testes cutâneos Alergia Alergenos Meio ambiente Higiene Humanos Crianças Brazil |
| topic |
Testes cutâneos Alergia Alergenos Meio ambiente Higiene Humanos Crianças Brazil Skin test Allergy Allergens Environmental Hygiene Humans Children Brazil Testes cutâneos Alergia Alergenos Meio ambiente Higiene Humanos Crianças Brazi |
| dc.subject.en.pt_BR.fl_str_mv |
Skin test Allergy Allergens Environmental Hygiene Humans Children Brazil |
| dc.subject.decs.pt_BR.fl_str_mv |
Testes cutâneos Alergia Alergenos Meio ambiente Higiene Humanos Crianças Brazi |
| description |
HCPC Latin America Excellence Centre Programme (072405/Z/03/Z) and grant 088862/Z/09/Z; and INCT/MCT/CNPq Programme (Contract no. 5737862008-9). We thank CAPES, CNPq and FAPESB |
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2017 |
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2017-06-12T14:01:00Z |
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2017-06-12T14:01:00Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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NEVES, N. M. A. et al. Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children. Plos One, 2017 |
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https://www.arca.fiocruz.br/handle/icict/19364 |
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1932-6203 |
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10.1371/journal.pone.0174089 |
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NEVES, N. M. A. et al. Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children. Plos One, 2017 1932-6203 10.1371/journal.pone.0174089 |
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https://www.arca.fiocruz.br/handle/icict/19364 |
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Public Library of Science |
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