Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni

Detalhes bibliográficos
Autor(a) principal: Pereira, Neusa Araújo
Data de Publicação: 2008
Outros Autores: Mattos, Ana Carolina Alves de, Sarvel, Ana Karine, Coelho, Paulo Marcos Zech, Katz, Naftale
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54473
Resumo: FUNDAÇÃO OSWALDO CRUZ
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spelling Pereira, Neusa AraújoMattos, Ana Carolina Alves deSarvel, Ana KarineCoelho, Paulo Marcos ZechKatz, Naftale2022-08-05T14:14:00Z2022-08-05T14:14:00Z2008ARAÚJO, Neusa Pereira et al. Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni. Mem. Inst. Oswaldo Cruz, v. 103, n. 5, p. 450-454, 2008. doi.org/10.1590/S0074-027620080005000070074-0276https://www.arca.fiocruz.br/handle/icict/5447310.1590/S0074-02762008000500007FUNDAÇÃO OSWALDO CRUZFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/ Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/ Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Esquistossomose. Belo Horizonte, MG, Brazil/ Santa Casa de Misericórdia de Belo Horizonte. Belo Horizonte, MG, BrazilThe activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni. Forty days after infection, mice were treated with lovastatin, 400 mg/kg for five consecutive days by oral route, and on the last day of this sequence with 50 mg/kg oxamniquine or with 200 mg/kg praziquantel, both by oral route, single dose. Fifteen days later, the animals were perfused in parallel with an untreated control group. Studies were carried out in vitro, using lovastatin in culture medium containing S. mansoni worms proceeding from experimentally infected mice. In the in vivo trials, the association of lovastatin with oxamniquine or praziquantel did not show any additive action, but there were oogram changes when lovastatin was associated with oxamniquine. In vitro lovastatin was able to interrupt the maturation of S. mansoni eggs, which remained at the 1st or 2nd stages, depending on the dose used. The total number of morphologically dead eggs found in culture of worms exposed to 2 mu g/ml or 4 mu g/ml concentrations of lovastatin was significantly higher than the number of viable eggs. Using the probe Hoescht 33258 it was observed that 70% of the eggs considered morphologically viable in the treated groups (against 16% in the control group) were labeled, indicating that the majority of the viable eggs had membrane permeability increased due to lovastatin actionengInstituto Oswaldo CruzOxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSchistosoma mansonilovastatindrug associationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSarvel, Ana.pdfSarvel, Ana.pdfapplication/pdf723376https://www.arca.fiocruz.br/bitstream/icict/54473/2/Sarvel%2c%20Ana.pdf3e1a2ed9452bf8fded08626fd351d1deMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/54473/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/544732022-08-05 11:14:00.606oai:www.arca.fiocruz.br:icict/54473Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-08-05T14:14Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
title Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
spellingShingle Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
Pereira, Neusa Araújo
Schistosoma mansoni
lovastatin
drug association
title_short Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
title_full Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
title_fullStr Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
title_full_unstemmed Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
title_sort Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
author Pereira, Neusa Araújo
author_facet Pereira, Neusa Araújo
Mattos, Ana Carolina Alves de
Sarvel, Ana Karine
Coelho, Paulo Marcos Zech
Katz, Naftale
author_role author
author2 Mattos, Ana Carolina Alves de
Sarvel, Ana Karine
Coelho, Paulo Marcos Zech
Katz, Naftale
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pereira, Neusa Araújo
Mattos, Ana Carolina Alves de
Sarvel, Ana Karine
Coelho, Paulo Marcos Zech
Katz, Naftale
dc.subject.en.pt_BR.fl_str_mv Schistosoma mansoni
lovastatin
drug association
topic Schistosoma mansoni
lovastatin
drug association
description FUNDAÇÃO OSWALDO CRUZ
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2022-08-05T14:14:00Z
dc.date.available.fl_str_mv 2022-08-05T14:14:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO, Neusa Pereira et al. Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni. Mem. Inst. Oswaldo Cruz, v. 103, n. 5, p. 450-454, 2008. doi.org/10.1590/S0074-02762008000500007
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54473
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02762008000500007
identifier_str_mv ARAÚJO, Neusa Pereira et al. Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni. Mem. Inst. Oswaldo Cruz, v. 103, n. 5, p. 450-454, 2008. doi.org/10.1590/S0074-02762008000500007
0074-0276
10.1590/S0074-02762008000500007
url https://www.arca.fiocruz.br/handle/icict/54473
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz
publisher.none.fl_str_mv Instituto Oswaldo Cruz
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