Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths

Detalhes bibliográficos
Autor(a) principal: Alexander, Neal
Data de Publicação: 2011
Outros Autores: Cundill, Bonnie, Sabatelli, Lorenzo, Bethony, Jeffrey Michael, Diemert, David, Hotez, Peter Jay, Smith, Peter G., Rodrigues, Laura C., Brooker, Simon
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8065
Resumo: London School of Hygiene and Tropical Medicine. London, UK/ The George Washington University.Washington, DC, USA.
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spelling Alexander, NealCundill, BonnieSabatelli, LorenzoBethony, Jeffrey MichaelDiemert, DavidHotez, Peter JaySmith, Peter G.Rodrigues, Laura C.Brooker, Simon2014-07-23T13:21:36Z2014-07-23T13:21:36Z2011ALEXANDER, Neal et al. Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths. Vaccine, v. 29, n. 20, p. 3686-3694. 2011.0264-410Xhttps://www.arca.fiocruz.br/handle/icict/806510.1016/j.vaccine.2011.03.026engElsevierSelection and quantification of infection endpoints for trials of vaccines against intestinal helminthsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLondon School of Hygiene and Tropical Medicine. London, UK/ The George Washington University.Washington, DC, USA.London School of Hygiene and Tropical Medicine. London, UK.London School of Hygiene and Tropical Medicine. London, UK.The George Washington University. Washington, DC, USA / Fundação Oswaldo Cruz.Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.Sabin Vaccine Institute. Washington, DC, USA / The George Washington University. Washington, DC, USA.Sabin Vaccine Institute. Washington, DC, USA / The George Washington University.Washington, DC, USA.London School of Hygiene and Tropical Medicine. London, UK.London School of Hygiene and Tropical Medicine. London, UK.London School of Hygiene and Tropical Medicine. London, UK.Vaccines against human helminths are being developed but the choice of optimal parasitological endpoints and effect measures to assess their efficacy has received little attention. Assuming negative binomial distributions for the parasite counts, we rank the statistical power of three measures of efficacy: ratio of mean parasite intensity at the end of the trial, the odds ratio of infection at the end of the trial, and the rate ratio of incidence of infection during the trial. We also use a modelling approach to estimate the likely impact of trial interventions on the force of infection, and hence statistical power. We conclude that (1) final mean parasite intensity is a suitable endpoint for later phase vaccine trials, and (2) mass effects of trial interventions are unlikely to appreciably reduce the force of infection in the community – and hence statistical power – unless there is a combination of high vaccine efficacy and a large proportion of the population enrolled.Helminth vaccinesParasitological endpointsMathematical modelinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALSelection and quantification of infection endpoints for trials of vaccines against intestinal helminths.pdfSelection and quantification of infection endpoints for trials of vaccines against intestinal helminths.pdfapplication/pdf338386https://www.arca.fiocruz.br/bitstream/icict/8065/1/Selection%20and%20quantification%20of%20infection%20endpoints%20for%20trials%20of%20vaccines%20against%20intestinal%20helminths.pdfd6673ef37bbd089542f183ee0180255aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8065/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTSelection and quantification of infection endpoints for trials of vaccines against intestinal helminths.pdf.txtSelection and quantification of infection endpoints for trials of vaccines against intestinal helminths.pdf.txtExtracted texttext/plain60023https://www.arca.fiocruz.br/bitstream/icict/8065/3/Selection%20and%20quantification%20of%20infection%20endpoints%20for%20trials%20of%20vaccines%20against%20intestinal%20helminths.pdf.txt98455c247997409dfb274dae50367514MD53icict/80652019-12-23 20:07:55.143oai:www.arca.fiocruz.br:icict/8065TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-12-23T23:07:55Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
title Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
spellingShingle Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
Alexander, Neal
Helminth vaccines
Parasitological endpoints
Mathematical model
title_short Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
title_full Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
title_fullStr Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
title_full_unstemmed Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
title_sort Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths
author Alexander, Neal
author_facet Alexander, Neal
Cundill, Bonnie
Sabatelli, Lorenzo
Bethony, Jeffrey Michael
Diemert, David
Hotez, Peter Jay
Smith, Peter G.
Rodrigues, Laura C.
Brooker, Simon
author_role author
author2 Cundill, Bonnie
Sabatelli, Lorenzo
Bethony, Jeffrey Michael
Diemert, David
Hotez, Peter Jay
Smith, Peter G.
Rodrigues, Laura C.
Brooker, Simon
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alexander, Neal
Cundill, Bonnie
Sabatelli, Lorenzo
Bethony, Jeffrey Michael
Diemert, David
Hotez, Peter Jay
Smith, Peter G.
Rodrigues, Laura C.
Brooker, Simon
dc.subject.en.pt_BR.fl_str_mv Helminth vaccines
Parasitological endpoints
Mathematical model
topic Helminth vaccines
Parasitological endpoints
Mathematical model
description London School of Hygiene and Tropical Medicine. London, UK/ The George Washington University.Washington, DC, USA.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-07-23T13:21:36Z
dc.date.available.fl_str_mv 2014-07-23T13:21:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALEXANDER, Neal et al. Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths. Vaccine, v. 29, n. 20, p. 3686-3694. 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8065
dc.identifier.issn.none.fl_str_mv 0264-410X
dc.identifier.doi.none.fl_str_mv 10.1016/j.vaccine.2011.03.026
identifier_str_mv ALEXANDER, Neal et al. Selection and quantification of infection endpoints for trials of vaccines against intestinal helminths. Vaccine, v. 29, n. 20, p. 3686-3694. 2011.
0264-410X
10.1016/j.vaccine.2011.03.026
url https://www.arca.fiocruz.br/handle/icict/8065
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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