The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31208 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil. |
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Fonseca, Erica L.Andrade, Bruno G. N.Vicente, Ana C. P.2019-01-22T11:46:59Z2019-01-22T11:46:59Z2018FONSECA, Érica L.; ANDRADE, Bruno G. N.; VICENTE, Ana C. P. The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-b-Lactamases Homologs. Frontiers in Microbiology, v.9, Article 677, 7p, Apr. 2018.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/3120810.3389/fmicb.2018.00677engFrontiers Mediaambiente marinhogene de resistência a antibióticosambiente intocadoresistomemetallo-b-lactamasesmarine environmentVIMSPM-1distant homologantibiotic resistance genepristine environmentThe Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.The worldwide dispersion and sudden emergence of new antibiotic resistance genes (ARGs) determined the need in uncovering which environment participate most as their source and reservoir. ARGs closely related to those currently found in human pathogens occur in the resistome of anthropogenic impacted environments. However, the role of pristine environment as the origin and source of ARGs remains underexplored and controversy, particularly, the marine environments represented by the oceans. Here, due to the ocean nature, we hypothesized that the resistome of this pristine/low-impacted marine environment is represented by distant ARG homologs. To test this hypothesis we performed an in silico analysis on the Global Ocean Sampling (GOS) metagenomic project dataset focusing on the metallo-β-lactamases (MβLs) as the ARG model. MβLs have been a challenge to public health, since they hydrolyze the carbapenems, one of the last therapeutic choice in clinics. Using Hidden Markov Model (HMM) profiles, we were successful in identifying a high diversity of distant MβL homologs, related to the B1, B2, and B3 subclasses. The majority of them were distributed across the Atlantic, Indian, and Pacific Oceans being related to the chromosomally encoded MβL GOB present in Elizabethkingia genus. It was observed only a reduced number of metagenomic sequence homologs related to the acquired MβL enzymes (VIM, SPM-1, and AIM-1) that currently have impact in clinics. Therefore, low antibiotic impacted marine environment, as the ocean, are unlikely the source of ARGs that have been causing enormous threat to the public health.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31208/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALerical_fonseca_etal_IOC_2018.pdferical_fonseca_etal_IOC_2018.pdfapplication/pdf975576https://www.arca.fiocruz.br/bitstream/icict/31208/2/erical_fonseca_etal_IOC_2018.pdfdc109848c50757740435aa0c255fb21cMD52TEXTerical_fonseca_etal_IOC_2018.pdf.txterical_fonseca_etal_IOC_2018.pdf.txtExtracted texttext/plain37707https://www.arca.fiocruz.br/bitstream/icict/31208/3/erical_fonseca_etal_IOC_2018.pdf.txt242d6e46a2e27dbfc21b38b40c2d9248MD53icict/312082022-06-24 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dc.title.pt_BR.fl_str_mv |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs |
title |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs |
spellingShingle |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs Fonseca, Erica L. ambiente marinho gene de resistência a antibióticos ambiente intocado resistome metallo-b-lactamases marine environment VIM SPM-1 distant homolog antibiotic resistance gene pristine environment |
title_short |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs |
title_full |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs |
title_fullStr |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs |
title_full_unstemmed |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs |
title_sort |
The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs |
author |
Fonseca, Erica L. |
author_facet |
Fonseca, Erica L. Andrade, Bruno G. N. Vicente, Ana C. P. |
author_role |
author |
author2 |
Andrade, Bruno G. N. Vicente, Ana C. P. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Fonseca, Erica L. Andrade, Bruno G. N. Vicente, Ana C. P. |
dc.subject.other.pt_BR.fl_str_mv |
ambiente marinho gene de resistência a antibióticos ambiente intocado |
topic |
ambiente marinho gene de resistência a antibióticos ambiente intocado resistome metallo-b-lactamases marine environment VIM SPM-1 distant homolog antibiotic resistance gene pristine environment |
dc.subject.en.pt_BR.fl_str_mv |
resistome metallo-b-lactamases marine environment VIM SPM-1 distant homolog antibiotic resistance gene pristine environment |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-01-22T11:46:59Z |
dc.date.available.fl_str_mv |
2019-01-22T11:46:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FONSECA, Érica L.; ANDRADE, Bruno G. N.; VICENTE, Ana C. P. The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-b-Lactamases Homologs. Frontiers in Microbiology, v.9, Article 677, 7p, Apr. 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31208 |
dc.identifier.issn.pt_BR.fl_str_mv |
1664-302X |
dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2018.00677 |
identifier_str_mv |
FONSECA, Érica L.; ANDRADE, Bruno G. N.; VICENTE, Ana C. P. The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-b-Lactamases Homologs. Frontiers in Microbiology, v.9, Article 677, 7p, Apr. 2018. 1664-302X 10.3389/fmicb.2018.00677 |
url |
https://www.arca.fiocruz.br/handle/icict/31208 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media |
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Frontiers Media |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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