Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Coelho, Lara E.
Data de Publicação: 2023
Outros Autores: Torres, Thiago S., Jalil, Emilia M., Cardoso, Sandra W., Moreira, Ronaldo I., Calvet, Guilherme A., Pacheco, Antônio G., Veloso, Valdiléa G., Grinsztejn, Beatriz, Luz, Paula M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57955
Resumo: This work was supported in part by NIH-funded Caribbean, Central and South America network for HIV epidemiology (CCASAnet), a member cohort of the International Epidemiologic Databases to Evaluate AIDS (leDEA) (U01AI069923) and Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz. AGP, BG, PML, TST acknowledge funding from Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq) and Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ).
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spelling Coelho, Lara E.Torres, Thiago S.Jalil, Emilia M.Cardoso, Sandra W.Moreira, Ronaldo I.Calvet, Guilherme A.Pacheco, Antônio G.Veloso, Valdiléa G.Grinsztejn, BeatrizLuz, Paula M.2023-04-24T22:31:12Z2023-04-24T22:31:12Z2023COELHO, Lara E. et al. Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases, v. 27, n. 2, p. 1-11, Mar./Apr. 2023.1413-8670https://www.arca.fiocruz.br/handle/icict/5795510.1016/j.bjid.2023.1027401678-4391This work was supported in part by NIH-funded Caribbean, Central and South America network for HIV epidemiology (CCASAnet), a member cohort of the International Epidemiologic Databases to Evaluate AIDS (leDEA) (U01AI069923) and Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz. AGP, BG, PML, TST acknowledge funding from Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq) and Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ).Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Background: Antiretroviral therapy use has led to a decline in HIV-related mortality yet disparities by gender and/or sexual orientation may exist. In this study, we estimated hazards of death in people living with HIV (PLWH) according to gender and sexual orientation. Methods: We included PLWH ≥ 18 years enrolled between 2000 and 2018 at INI/Fiocruz, Rio de Janeiro, Brazil. Participants were grouped as cisgender or transgender women, cisgender men who have sex with men (MSM) or men who have sex with women, or cisgender men with unknown sexual orientation. We assessed disparities in the hazard of death using Cox proportional hazards models. Results: Among 5,576 PLWH, median age at enrollment was 35 years, 39% were MSM, 28% cisgender women, 23% men who have sex with women, 5% transgender women, and 5% men with unknown sexual orientation. A total of 795 deaths occurred in 39,141 person-years of follow-up. Mortality rates per 1,000 person-years were: 82.4 for men with unknown sexual orientation, 24.5 for men who have sex with women, 18.3 for cisgender, 16.6 for transgender women, and 15.1 for MSM. Compared to MSM, men with unknown sexual orientation had the highest death hazard ratio (adjusted hazard ratio [aHR] 2.93, 95% confidence interval [CI] 2.35-3.81), followed by men who have sex with women (aHR 1.17, 95%CI 0.96, 1.43); death hazard ratios for cisgender and transgender women were not statistically different. Conclusion: We observed disparities in the hazard of death for men with unknown sexual orientation and men who have sex with women despite universal access to antiretroviral therapy in Brazil. Future work should characterize and assist men with unknown sexual orientation with tailored policies and interventions. Increased hazard of death was not observed for transgender women, which probably results from interventions implemented in our service to reach, engage, retain, and support this population.engSociedade Brasileira de InfectologiaMortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDisclosureGenderHIV/AIDSMortalitySexual orientationSurvivalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
title Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
spellingShingle Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
Coelho, Lara E.
Disclosure
Gender
HIV/AIDS
Mortality
Sexual orientation
Survival
title_short Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
title_full Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
title_fullStr Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
title_full_unstemmed Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
title_sort Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil
author Coelho, Lara E.
author_facet Coelho, Lara E.
Torres, Thiago S.
Jalil, Emilia M.
Cardoso, Sandra W.
Moreira, Ronaldo I.
Calvet, Guilherme A.
Pacheco, Antônio G.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula M.
author_role author
author2 Torres, Thiago S.
Jalil, Emilia M.
Cardoso, Sandra W.
Moreira, Ronaldo I.
Calvet, Guilherme A.
Pacheco, Antônio G.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula M.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Coelho, Lara E.
Torres, Thiago S.
Jalil, Emilia M.
Cardoso, Sandra W.
Moreira, Ronaldo I.
Calvet, Guilherme A.
Pacheco, Antônio G.
Veloso, Valdiléa G.
Grinsztejn, Beatriz
Luz, Paula M.
dc.subject.en.en_US.fl_str_mv Disclosure
Gender
HIV/AIDS
Mortality
Sexual orientation
Survival
topic Disclosure
Gender
HIV/AIDS
Mortality
Sexual orientation
Survival
description This work was supported in part by NIH-funded Caribbean, Central and South America network for HIV epidemiology (CCASAnet), a member cohort of the International Epidemiologic Databases to Evaluate AIDS (leDEA) (U01AI069923) and Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz. AGP, BG, PML, TST acknowledge funding from Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq) and Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ).
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-04-24T22:31:12Z
dc.date.available.fl_str_mv 2023-04-24T22:31:12Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COELHO, Lara E. et al. Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases, v. 27, n. 2, p. 1-11, Mar./Apr. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57955
dc.identifier.issn.en_US.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2023.102740
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv COELHO, Lara E. et al. Mortality rates by gender and sexual orientation reveal a disproportionally high mortality among cisgender men of unknown sexual orientation and men who have sex with women in a cohort of people living with HIV in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases, v. 27, n. 2, p. 1-11, Mar./Apr. 2023.
1413-8670
10.1016/j.bjid.2023.102740
1678-4391
url https://www.arca.fiocruz.br/handle/icict/57955
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Sociedade Brasileira de Infectologia
publisher.none.fl_str_mv Sociedade Brasileira de Infectologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57955/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/57955/2/ve_Coelho_Lara_etal_INI_PROCC_2023.pdf
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