Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation

Detalhes bibliográficos
Autor(a) principal: d`Avila, Joana Costa
Data de Publicação: 2018
Outros Autores: Siqueira, Luciana Domett, Mazeraud, Aurélien, Azevedo, Estefania Pereira, Foguel, Debora, Faria Neto, Hugo Caire Castro, Sharshar, Tarek, Chrétien, Fabrice, Bozza, Fernando Augusto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28462
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
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spelling d`Avila, Joana CostaSiqueira, Luciana DomettMazeraud, AurélienAzevedo, Estefania PereiraFoguel, DeboraFaria Neto, Hugo Caire CastroSharshar, TarekChrétien, FabriceBozza, Fernando Augusto2018-08-30T12:21:35Z2018-08-30T12:21:35Z2018d`AVILA, Joana Costa et al. Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation. Journal of Neuroinflammation, v. 15, n. 28, p. 1-13, Jan. 2018.1742-2094https://www.arca.fiocruz.br/handle/icict/2846210.1186/s12974-018-1059-yengBioMed CentralNeuroinflamaçãoEstresse OxidativoComprometimento cognitivo relacionado à idadeInflamação sistêmica episódicaNeuroinflammationOxidative stressEpisodic systemic inflammationAge-related cognitive impairmentAge-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Pasteur Institute. Human Histopathology and Animal Models. Paris, France.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Pasteur Institute. Human Histopathology and Animal Models. Paris, France.Pasteur Institute. Human Histopathology and Animal Models. Paris, France.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Instituto IDÓR de Pesquisa e Educação. Rio de Janeiro, RJ, Brasil.Background: Microglia function is essential to maintain the brain homeostasis. Evidence shows that aged microglia are primed and show exaggerated response to acute inflammatory challenge. Systemic inflammation signals to the brain inducing changes that impact cognitive function. However, the mechanisms involved in age-related cognitive decline associated to episodic systemic inflammation are not completely understood. The aim of this study was to identify neuropathological features associated to age-related cognitive decline in a mouse model of episodic systemic inflammation. Methods: Young and aged Swiss mice were injected with low doses of LPS once a week for 6 weeks to induce episodic systemic inflammation. Sickness behavior, inflammatory markers, and neuroinflammation were assessed in different phases of systemic inflammation in young and aged mice. Behavior was evaluated long term after episodic systemic inflammation by open field, forced swimming, object recognition, and water maze tests. Results: Episodic systemic inflammation induced systemic inflammation and sickness behavior mainly in aged mice. Systemic inflammation induced depressive-like behavior in both young and aged mice. Memory and learning were significantly affected in aged mice that presented lower exploratory activity and deficits in episodic and spatial memories, compared to aged controls and to young after episodic systemic inflammation. Systemic inflammation induced acute microglia activation in young mice that returned to base levels long term after episodic systemic inflammation. Aged mice presented dystrophic microglia in the hippocampus and entorhinal cortex at basal level and did not change morphology in the acute response to SI. Regardless of their dystrophic microglia, aged mice produced higher levels of pro-inflammatory (IL-1β and IL-6) as well as pro-resolution (IL-10 and IL-4) cytokines in the brain. Also, higher levels of Nox2 expression, oxidized proteins and lower antioxidant defenses were found in the aged brains compared to the young after episodic systemic inflammation. Conclusions: Our data show that aged mice have increased susceptibility to episodic systemic inflammation. Aged mice that showed cognitive impairments also presented higher oxidative stress and abnormal production of cytokines in their brains. These results indicate that a neuroinflammation and oxidative stress are pathophysiological mechanisms of age-related cognitive impairments.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28462/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALjoana_dàvila_etal_IOC_2018.pdfjoana_dàvila_etal_IOC_2018.pdfapplication/pdf2111790https://www.arca.fiocruz.br/bitstream/icict/28462/2/joana_d%c3%a0vila_etal_IOC_2018.pdf53846769c9b0894950582b8bddf81832MD52TEXTjoana_dàvila_etal_IOC_2018.pdf.txtjoana_dàvila_etal_IOC_2018.pdf.txtExtracted texttext/plain62918https://www.arca.fiocruz.br/bitstream/icict/28462/3/joana_d%c3%a0vila_etal_IOC_2018.pdf.txt79869a8b2949bce5459ea3fbad1fb276MD53icict/284622023-10-28 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dc.title.pt_BR.fl_str_mv Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
title Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
spellingShingle Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
d`Avila, Joana Costa
Neuroinflamação
Estresse Oxidativo
Comprometimento cognitivo relacionado à idade
Inflamação sistêmica episódica
Neuroinflammation
Oxidative stress
Episodic systemic inflammation
Age-related cognitive impairment
title_short Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
title_full Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
title_fullStr Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
title_full_unstemmed Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
title_sort Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation
author d`Avila, Joana Costa
author_facet d`Avila, Joana Costa
Siqueira, Luciana Domett
Mazeraud, Aurélien
Azevedo, Estefania Pereira
Foguel, Debora
Faria Neto, Hugo Caire Castro
Sharshar, Tarek
Chrétien, Fabrice
Bozza, Fernando Augusto
author_role author
author2 Siqueira, Luciana Domett
Mazeraud, Aurélien
Azevedo, Estefania Pereira
Foguel, Debora
Faria Neto, Hugo Caire Castro
Sharshar, Tarek
Chrétien, Fabrice
Bozza, Fernando Augusto
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv d`Avila, Joana Costa
Siqueira, Luciana Domett
Mazeraud, Aurélien
Azevedo, Estefania Pereira
Foguel, Debora
Faria Neto, Hugo Caire Castro
Sharshar, Tarek
Chrétien, Fabrice
Bozza, Fernando Augusto
dc.subject.other.pt_BR.fl_str_mv Neuroinflamação
Estresse Oxidativo
Comprometimento cognitivo relacionado à idade
Inflamação sistêmica episódica
topic Neuroinflamação
Estresse Oxidativo
Comprometimento cognitivo relacionado à idade
Inflamação sistêmica episódica
Neuroinflammation
Oxidative stress
Episodic systemic inflammation
Age-related cognitive impairment
dc.subject.en.pt_BR.fl_str_mv Neuroinflammation
Oxidative stress
Episodic systemic inflammation
Age-related cognitive impairment
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-08-30T12:21:35Z
dc.date.available.fl_str_mv 2018-08-30T12:21:35Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv d`AVILA, Joana Costa et al. Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation. Journal of Neuroinflammation, v. 15, n. 28, p. 1-13, Jan. 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28462
dc.identifier.issn.pt_BR.fl_str_mv 1742-2094
dc.identifier.doi.none.fl_str_mv 10.1186/s12974-018-1059-y
identifier_str_mv d`AVILA, Joana Costa et al. Age-related cognitive impairment is associated with long-term neuroinflammation and oxidative stress in a mouse model of episodic systemic inflammation. Journal of Neuroinflammation, v. 15, n. 28, p. 1-13, Jan. 2018.
1742-2094
10.1186/s12974-018-1059-y
url https://www.arca.fiocruz.br/handle/icict/28462
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/28462/2/joana_d%c3%a0vila_etal_IOC_2018.pdf
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