Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods

Detalhes bibliográficos
Autor(a) principal: Vlaminck, Johnny
Data de Publicação: 2019
Outros Autores: Cools, Piet, Albonico, Marco, Ame, Shaali, Ayana, Mio, Cringoli, Giuseppe, Dana, Daniel, Keiser, Jennifer, Maurelli, Maria P, Matoso, Leonardo Ferreira, Montresor, Antonio, Mekonnen, Zeleke, Mirams, Greg, Oliveira, Rodrigo Corrêa, Pinto, Simone Aparecida, Rinaldi, Laura, Sayasone, Somphou, Thomas, Eurion, Vercruysse, Jozef, Verweij, Jaco J, Levecke, Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58358
Resumo: Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.
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spelling Vlaminck, JohnnyCools, PietAlbonico, MarcoAme, ShaaliAyana, MioCringoli, GiuseppeDana, DanielKeiser, JenniferMaurelli, Maria PMatoso, Leonardo FerreiraMontresor, AntonioMekonnen, ZelekeMirams, GregOliveira, Rodrigo CorrêaPinto, Simone AparecidaRinaldi, LauraSayasone, SomphouThomas, EurionVercruysse, JozefVerweij, Jaco JLevecke, Bruno2023-05-12T16:57:33Z2023-05-12T16:57:33Z2019VLAMINCK, Johnny et al. Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods. PLoS Negl Trop Dis., v. 13, n. 8, e0007471, 2019. doi: 10.1371/journal.pntd.0007471.1935-2735https://www.arca.fiocruz.br/handle/icict/5835810.1371/journal.pntd.0007471engPublic Library of ScienceTherapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methodsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Center for Tropical Diseases. Sacro Cuore Don Calabria Hospital. Negrar, Italy/Department of Life Sciences and Systems Biology. University of Turin. Turin, Italy.Laboratory Division, Public Health Laboratory-Ivo de Carneri. Chake Chake, United Republic of Tanzania.Jimma University Institute of Health. Jimma University. Jimma, Ethiopia.Department of Veterinary Medicine and Animal Production. University of Naples Federico II. Naples, Italy.Jimma University Institute of Health. Jimma University. Jimma, Ethiopia.Department of Medical Parasitology and Infection Biology. Swiss Tropical and Public Health Institute. Basel, Switzerland/University of Basel. Basel, Switzerland.Department of Veterinary Medicine and Animal Production. University of Naples Federico II. Naples, Italy.Laboratory of Molecular and Cellular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil/Nursing school. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil.Department of Control of Neglected Tropical Diseases. World Health Organization. Geneva, Switzerland.Jimma University Institute of Health. Jimma University. Jimma, Ethiopia.Techion Group Ltd. Dunedin, New ZealandLaboratory of Molecular and Cellular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, BrazilLaboratory of Molecular and Cellular Immunology. René Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, BrazilDepartment of Veterinary Medicine and Animal Production. University of Naples Federico II. Naples, Italy.Lao Tropical and Public Health Institute. Ministry of Health, Vientiane, Lao People's Democratic Republic.Techion Group Ltd. Aberystwyth. United Kingdom.Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Laboratory for Medical Microbiology and Immunology. Elisabeth-TweeSteden Hospital. Tilburg, The Netherlands.Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.Background: Preventive chemotherapy (PC) with benzimidazole drugs is the backbone of soil-transmitted helminth (STH) control programs. Over the past decade, drug coverage has increased and with it, the possibility of developing anthelmintic resistance. It is therefore of utmost importance to monitor drug efficacy. Currently, a variety of novel diagnostic methods are available, but it remains unclear whether they can be used to monitor drug efficacy. In this study, we compared the efficacy of albendazole (ALB) measured by different diagnostic methods in a head-to-head comparison to the recommended single Kato-Katz. Methods: An ALB efficacy trial was performed in 3 different STH-endemic countries (Ethiopia, Lao PDR and Tanzania), each with a different PC-history. During these trials, stool samples were evaluated with Kato-Katz (single and duplicate), Mini-FLOTAC, FECPAKG2, and qPCR. The reduction rate in mean eggs per gram of stool (ERR) and mean genome equivalents / ml of DNA extract (GERR) were calculated to estimate drug efficacy. Principal findings and conclusions: The results of the efficacy trials showed that none of the evaluated diagnostic methods could provide reduction rates that were equivalent to a single Kato-Katz for all STH. However, despite differences in clinical sensitivity and egg counts, they agreed in classifying efficacy according to World Health Organization (WHO) guidelines. This demonstrates that diagnostic methods for assessing drug efficacy should be validated with their intended-use in mind and that other factors like user-friendliness and costs will likely be important factors in driving the choice of diagnostics. In addition, ALB efficacy against STH infections was lower in sites with a longer history of PC. Yet, further research is needed to identify factors that contribute to this finding and to verify whether reduced efficacy can be associated with mutations in the β-tubulin gene that have previously been linked to anthelmintic resistance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALTherapeutic efficacy of albendazole against.pdfTherapeutic efficacy of albendazole against.pdfapplication/pdf2297498https://www.arca.fiocruz.br/bitstream/icict/58358/2/Therapeutic%20efficacy%20of%20albendazole%20against.pdf51fa5563720cc4946ae8a59f42b4ef83MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58358/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/583582023-05-12 13:57:34.238oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-12T16:57:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
title Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
spellingShingle Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
Vlaminck, Johnny
title_short Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
title_full Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
title_fullStr Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
title_full_unstemmed Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
title_sort Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods
author Vlaminck, Johnny
author_facet Vlaminck, Johnny
Cools, Piet
Albonico, Marco
Ame, Shaali
Ayana, Mio
Cringoli, Giuseppe
Dana, Daniel
Keiser, Jennifer
Maurelli, Maria P
Matoso, Leonardo Ferreira
Montresor, Antonio
Mekonnen, Zeleke
Mirams, Greg
Oliveira, Rodrigo Corrêa
Pinto, Simone Aparecida
Rinaldi, Laura
Sayasone, Somphou
Thomas, Eurion
Vercruysse, Jozef
Verweij, Jaco J
Levecke, Bruno
author_role author
author2 Cools, Piet
Albonico, Marco
Ame, Shaali
Ayana, Mio
Cringoli, Giuseppe
Dana, Daniel
Keiser, Jennifer
Maurelli, Maria P
Matoso, Leonardo Ferreira
Montresor, Antonio
Mekonnen, Zeleke
Mirams, Greg
Oliveira, Rodrigo Corrêa
Pinto, Simone Aparecida
Rinaldi, Laura
Sayasone, Somphou
Thomas, Eurion
Vercruysse, Jozef
Verweij, Jaco J
Levecke, Bruno
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Vlaminck, Johnny
Cools, Piet
Albonico, Marco
Ame, Shaali
Ayana, Mio
Cringoli, Giuseppe
Dana, Daniel
Keiser, Jennifer
Maurelli, Maria P
Matoso, Leonardo Ferreira
Montresor, Antonio
Mekonnen, Zeleke
Mirams, Greg
Oliveira, Rodrigo Corrêa
Pinto, Simone Aparecida
Rinaldi, Laura
Sayasone, Somphou
Thomas, Eurion
Vercruysse, Jozef
Verweij, Jaco J
Levecke, Bruno
description Department of Virology. Parasitology and Immunology. Ghent University. Merelbeke, Belgium.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2023-05-12T16:57:33Z
dc.date.available.fl_str_mv 2023-05-12T16:57:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv VLAMINCK, Johnny et al. Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods. PLoS Negl Trop Dis., v. 13, n. 8, e0007471, 2019. doi: 10.1371/journal.pntd.0007471.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58358
dc.identifier.issn.en_US.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0007471
identifier_str_mv VLAMINCK, Johnny et al. Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods. PLoS Negl Trop Dis., v. 13, n. 8, e0007471, 2019. doi: 10.1371/journal.pntd.0007471.
1935-2735
10.1371/journal.pntd.0007471
url https://www.arca.fiocruz.br/handle/icict/58358
dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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