Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum

Detalhes bibliográficos
Autor(a) principal: Silva, Rangeline Azevedo da
Data de Publicação: 2018
Outros Autores: Pereira, Leandro de Mattos, Silveira, Melise Chaves, Jardim, Rodrigo, Miranda, Antonio Basilio de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28855
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
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spelling Silva, Rangeline Azevedo daPereira, Leandro de MattosSilveira, Melise ChavesJardim, RodrigoMiranda, Antonio Basilio de2018-09-18T13:40:21Z2018-09-18T13:40:21Z2018SILVA, Rangeline Azevedo da; et al. Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum. PloS ONE, v.13, n.5, e0197511, 20p, May 2018.1932-6203https://www.arca.fiocruz.br/handle/icict/2885510.1371/journal.pone.0197511engPublic Library of SciencePesticidasGenomaspatógenos de plantasenzimaspotenciais alvos de drogasGlycine maxZea maysSolanum lycopersicumpotential drug targetsdiseasesenzymesplant pathogenspesticidesMining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicuminfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Pontifícia Universidade Católica do Rio Grande do Sul. Porto Alegre, RS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Pesticides are one of the most widely used pest and disease control measures in plant crops and their indiscriminate use poses a direct risk to the health of populations and environment around the world. As a result, there is a great need for the development of new, less toxic molecules to be employed against plant pathogens. In this work, we employed an in silico approach to study the genes coding for enzymes of the genomes of three commercially important plants, soybean (Glycine max), tomato (Solanum lycopersicum) and corn (Zea mays), as well as 15 plant pathogens (4 bacteria and 11 fungi), focusing on revealing a set of essential and non-homologous isofunctional enzymes (NISEs) that could be prioritized as drug targets. By combining sequence and structural data, we obtained an initial set of 568 cases of analogy, of which 97 were validated and further refined, revealing a subset of 29 essential enzymatic activities with a total of 119 different structural forms, most belonging to central metabolic routes, including the carbohydrate metabolism, the metabolism of amino acids, among others. Further, another subset of 26 enzymatic activities possess a tertiary structure specific for the pathogen, not present in plants, men and Apis mellifera, which may be of importance for the development of specific enzymatic inhibitors against plant diseases that are less harmful to humans and the environment.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28855/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALrangeline_silva_etal_IOC_2018.pdfrangeline_silva_etal_IOC_2018.pdfapplication/pdf3275190https://www.arca.fiocruz.br/bitstream/icict/28855/2/rangeline_silva_etal_IOC_2018.pdfdca61d6c8e72eac27a68587743b3c437MD52TEXTrangeline_silva_etal_IOC_2018.pdf.txtrangeline_silva_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
title Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
spellingShingle Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
Silva, Rangeline Azevedo da
Pesticidas
Genomas
patógenos de plantas
enzimas
potenciais alvos de drogas
Glycine max
Zea mays
Solanum lycopersicum
potential drug targets
diseases
enzymes
plant pathogens
pesticides
title_short Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
title_full Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
title_fullStr Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
title_full_unstemmed Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
title_sort Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum
author Silva, Rangeline Azevedo da
author_facet Silva, Rangeline Azevedo da
Pereira, Leandro de Mattos
Silveira, Melise Chaves
Jardim, Rodrigo
Miranda, Antonio Basilio de
author_role author
author2 Pereira, Leandro de Mattos
Silveira, Melise Chaves
Jardim, Rodrigo
Miranda, Antonio Basilio de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Silva, Rangeline Azevedo da
Pereira, Leandro de Mattos
Silveira, Melise Chaves
Jardim, Rodrigo
Miranda, Antonio Basilio de
dc.subject.other.pt_BR.fl_str_mv Pesticidas
Genomas
patógenos de plantas
enzimas
potenciais alvos de drogas
topic Pesticidas
Genomas
patógenos de plantas
enzimas
potenciais alvos de drogas
Glycine max
Zea mays
Solanum lycopersicum
potential drug targets
diseases
enzymes
plant pathogens
pesticides
dc.subject.en.pt_BR.fl_str_mv Glycine max
Zea mays
Solanum lycopersicum
potential drug targets
diseases
enzymes
plant pathogens
pesticides
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-18T13:40:21Z
dc.date.available.fl_str_mv 2018-09-18T13:40:21Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Rangeline Azevedo da; et al. Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum. PloS ONE, v.13, n.5, e0197511, 20p, May 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28855
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0197511
identifier_str_mv SILVA, Rangeline Azevedo da; et al. Mining of potential drug targets through the identification of essential and analogous enzymes in the genomes of pathogens of Glycine max, Zea mays and Solanum lycopersicum. PloS ONE, v.13, n.5, e0197511, 20p, May 2018.
1932-6203
10.1371/journal.pone.0197511
url https://www.arca.fiocruz.br/handle/icict/28855
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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