Leishmania-Host Interplay: The Everlasting Rivalry

Detalhes bibliográficos
Autor(a) principal: Martiny, Andrea
Data de Publicação: 2005
Outros Autores: Santos, Marcos André Vannier dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29392
Resumo: Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - PROCAD) and Fundação Oswaldo Cruz (FIOCRUZ).
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spelling Martiny, AndreaSantos, Marcos André Vannier dos2018-10-05T17:02:35Z2018-10-05T17:02:35Z2005MARTINY, A.; SANTOS, M. A. V. dos Leishmania-Host Interplay: The Everlasting Rivalry. Medicinal Chemistry Reviews - Online, v. 2, p. 231-249, 2005.1567-2034https://www.arca.fiocruz.br/handle/icict/29392Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - PROCAD) and Fundação Oswaldo Cruz (FIOCRUZ).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAbstract: Parasitic protozoa of the genus Leishmania infect mammalian mononuclear phagocytic cells causing a potentially fatal disease with a broad spectrum of clinical manifestations. The drugs of choice used in the leishmaniasis therapy are significantly toxic, expensive and faced with a growing frequency of refractory infections. Thus the search for new leishmanicidal compounds is urgently required. In order to perform a proper drug design and to understand the modes of action of such compounds it is necessary to elucidade the intrincate cellular and molecular events that orchestrate the parasite biology. To invade host cells Leishmania recruit different surface receptors that may assist engaging the microbicidal responses. Even before gaining the intracellular millieu these pathogens can deactivate and/or subvert the phagocyte signal transduction machinery rendering these cells permissive to infection. In the present review we attempted to approach some of the most relevant cellular and biochemical invasion strategies employed by Leishmania parasites.engHilversum Bentham Science PublishersLeishmaniaParasitasTransdução de sinalReceptorQuimioterapiaMecanismos de evasãoLeishmaniaParasitesSignal transductionReceptorChemotherapyEvasion mechanismsLeishmania-Host Interplay: The Everlasting Rivalryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29392/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMartiny A Leishmania...2005.pdfMartiny A Leishmania...2005.pdfapplication/pdf406429https://www.arca.fiocruz.br/bitstream/icict/29392/2/Martiny%20A%20Leishmania...2005.pdfae384bd22ba7b8b5d04f19ead195e092MD52TEXTMartiny A 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dc.title.pt_BR.fl_str_mv Leishmania-Host Interplay: The Everlasting Rivalry
title Leishmania-Host Interplay: The Everlasting Rivalry
spellingShingle Leishmania-Host Interplay: The Everlasting Rivalry
Martiny, Andrea
Leishmania
Parasitas
Transdução de sinal
Receptor
Quimioterapia
Mecanismos de evasão
Leishmania
Parasites
Signal transduction
Receptor
Chemotherapy
Evasion mechanisms
title_short Leishmania-Host Interplay: The Everlasting Rivalry
title_full Leishmania-Host Interplay: The Everlasting Rivalry
title_fullStr Leishmania-Host Interplay: The Everlasting Rivalry
title_full_unstemmed Leishmania-Host Interplay: The Everlasting Rivalry
title_sort Leishmania-Host Interplay: The Everlasting Rivalry
author Martiny, Andrea
author_facet Martiny, Andrea
Santos, Marcos André Vannier dos
author_role author
author2 Santos, Marcos André Vannier dos
author2_role author
dc.contributor.author.fl_str_mv Martiny, Andrea
Santos, Marcos André Vannier dos
dc.subject.other.pt_BR.fl_str_mv Leishmania
Parasitas
Transdução de sinal
Receptor
Quimioterapia
Mecanismos de evasão
topic Leishmania
Parasitas
Transdução de sinal
Receptor
Quimioterapia
Mecanismos de evasão
Leishmania
Parasites
Signal transduction
Receptor
Chemotherapy
Evasion mechanisms
dc.subject.en.pt_BR.fl_str_mv Leishmania
Parasites
Signal transduction
Receptor
Chemotherapy
Evasion mechanisms
description Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES - PROCAD) and Fundação Oswaldo Cruz (FIOCRUZ).
publishDate 2005
dc.date.issued.fl_str_mv 2005
dc.date.accessioned.fl_str_mv 2018-10-05T17:02:35Z
dc.date.available.fl_str_mv 2018-10-05T17:02:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MARTINY, A.; SANTOS, M. A. V. dos Leishmania-Host Interplay: The Everlasting Rivalry. Medicinal Chemistry Reviews - Online, v. 2, p. 231-249, 2005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29392
dc.identifier.issn.pt_BR.fl_str_mv 1567-2034
identifier_str_mv MARTINY, A.; SANTOS, M. A. V. dos Leishmania-Host Interplay: The Everlasting Rivalry. Medicinal Chemistry Reviews - Online, v. 2, p. 231-249, 2005.
1567-2034
url https://www.arca.fiocruz.br/handle/icict/29392
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hilversum Bentham Science Publishers
publisher.none.fl_str_mv Hilversum Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/29392/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/29392/3/Martiny%20A%20Leishmania...2005.pdf.txt
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