Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS)
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16533 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
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Quintanilha, Isaclaudia G. de AzevedoAbreu, Adriana Vieira deFerreira, André CostaNascimento, Daniele O.Siqueira, Alessandra M.Campbell, Robert A.Ferreira, Tatiana P. TeixeiraGutierrez, Tatiana M.Ribeiro, Gabriel MSilva, Patrícia M. R. eCarvalho, Alysson R.Bozza, Patrícia T.Zimmerman, Guy A.Faria Neto, Hugo C. Castro2016-12-15T10:19:11Z2016-12-15T10:19:11Z2016QUINTANILHA, Isaclaudia G. de Azevedo; et al. Integrin αDβ2 (CD11d/CD18) mediates experimental malaria‑associated acute respiratory distress syndrome (MA‑ARDS). Malaria Journal. v.15:393, 15p, 2016.1475-2875https://www.arca.fiocruz.br/handle/icict/1653310.1186/s12936-016-1447-7engBioMed CentralMaláriaInflamaçãoSíndrome da insuficiência respiratória agudaLesão pulmonar agudaIntegrin αDβ2Acute lung injuryAcute respiratory distress syndromeMalariaInflammationIntegrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.University of Utah. Department of Internal Medicine. Program in Molecular Medicine. Salt Lake City, UT, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.University of Utah. Department of Internal Medicine. Program in Molecular Medicine. Salt Lake City, UT, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. COPPE, Instituto Alberto Luiz Coimbra de Pós-Graduação e Pesquisa de Engenharia. Laboratório de Engenharia Pulmonar no Programa deEngenharia Biomédica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Fisiologia da Respiração. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil.University of Utah. Department of Internal Medicine. Program in Molecular Medicine. Salt Lake City, UT, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil / Universidade Estácio de Sá. Programa de Produtividade Científica. Rio de Janeiro, RJ, Brasil.Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a potentially lethal complication of clinical malaria. Acute lung injury in MA-ARDS shares features with ARDS triggered by other causes, including alveolar inflammation and increased alveolar-capillary permeability, leading to leak of protein-rich pulmonary oedema fluid. Mechanisms and physiologic alterations in MA-ARDS can be examined in murine models of this syndrome. Integrin αDβ2 is a member of the leukocyte, or β2 (CD18), sub-family of integrins, and emerging observations indicate that it has important activities in leukocyte adhesion, accumulation and signalling. The goal was to perform analysis of the lungs of mice wild type C57Bl/6 (a D (+/+) ) and Knockout C57Bl/6 (a D (-/-) ) with malaria-associated acute lung injury to better determine the relevancy of the murine models and investigate the mechanism of disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16533/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALhugo2_farianeto_etal_IOC_2016.pdfhugo2_farianeto_etal_IOC_2016.pdfapplication/pdf2692456https://www.arca.fiocruz.br/bitstream/icict/16533/2/hugo2_farianeto_etal_IOC_2016.pdf44755c7835ed5968ec5b8ec7f9760774MD52TEXThugo2_farianeto_etal_IOC_2016.pdf.txthugo2_farianeto_etal_IOC_2016.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) |
| title |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) |
| spellingShingle |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) Quintanilha, Isaclaudia G. de Azevedo Malária Inflamação Síndrome da insuficiência respiratória aguda Lesão pulmonar aguda Integrin αDβ2 Acute lung injury Acute respiratory distress syndrome Malaria Inflammation |
| title_short |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) |
| title_full |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) |
| title_fullStr |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) |
| title_full_unstemmed |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) |
| title_sort |
Integrin αDβ2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS) |
| author |
Quintanilha, Isaclaudia G. de Azevedo |
| author_facet |
Quintanilha, Isaclaudia G. de Azevedo Abreu, Adriana Vieira de Ferreira, André Costa Nascimento, Daniele O. Siqueira, Alessandra M. Campbell, Robert A. Ferreira, Tatiana P. Teixeira Gutierrez, Tatiana M. Ribeiro, Gabriel M Silva, Patrícia M. R. e Carvalho, Alysson R. Bozza, Patrícia T. Zimmerman, Guy A. Faria Neto, Hugo C. Castro |
| author_role |
author |
| author2 |
Abreu, Adriana Vieira de Ferreira, André Costa Nascimento, Daniele O. Siqueira, Alessandra M. Campbell, Robert A. Ferreira, Tatiana P. Teixeira Gutierrez, Tatiana M. Ribeiro, Gabriel M Silva, Patrícia M. R. e Carvalho, Alysson R. Bozza, Patrícia T. Zimmerman, Guy A. Faria Neto, Hugo C. Castro |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Quintanilha, Isaclaudia G. de Azevedo Abreu, Adriana Vieira de Ferreira, André Costa Nascimento, Daniele O. Siqueira, Alessandra M. Campbell, Robert A. Ferreira, Tatiana P. Teixeira Gutierrez, Tatiana M. Ribeiro, Gabriel M Silva, Patrícia M. R. e Carvalho, Alysson R. Bozza, Patrícia T. Zimmerman, Guy A. Faria Neto, Hugo C. Castro |
| dc.subject.other.pt_BR.fl_str_mv |
Malária Inflamação Síndrome da insuficiência respiratória aguda Lesão pulmonar aguda |
| topic |
Malária Inflamação Síndrome da insuficiência respiratória aguda Lesão pulmonar aguda Integrin αDβ2 Acute lung injury Acute respiratory distress syndrome Malaria Inflammation |
| dc.subject.en.pt_BR.fl_str_mv |
Integrin αDβ2 Acute lung injury Acute respiratory distress syndrome Malaria Inflammation |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ. Brasil. |
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2016 |
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2016-12-15T10:19:11Z |
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2016-12-15T10:19:11Z |
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2016 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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QUINTANILHA, Isaclaudia G. de Azevedo; et al. Integrin αDβ2 (CD11d/CD18) mediates experimental malaria‑associated acute respiratory distress syndrome (MA‑ARDS). Malaria Journal. v.15:393, 15p, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16533 |
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1475-2875 |
| dc.identifier.doi.none.fl_str_mv |
10.1186/s12936-016-1447-7 |
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QUINTANILHA, Isaclaudia G. de Azevedo; et al. Integrin αDβ2 (CD11d/CD18) mediates experimental malaria‑associated acute respiratory distress syndrome (MA‑ARDS). Malaria Journal. v.15:393, 15p, 2016. 1475-2875 10.1186/s12936-016-1447-7 |
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BioMed Central |
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