Isolated intracranial hypertension associated with COVID-19
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/44312 |
Resumo: | A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/ |
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Silva, Marcus Tulius T.Lima, Marco A.Torezani, GuilhermeSoares, Cristiane N.Dantas, ClaudiaBrandão, Carlos OtávioEspíndola, OtávioSiqueira, Marilda Agudo Mendonça Teixeira deAraujo, Abelardo Q. C.2020-11-04T22:54:20Z2020-11-04T22:54:20Z2020SILVA, Marcus Tulius T. et al. Isolated intracranial hypertension associated with COVID-19. Cephalalgia, v. 40, n. 13, p. 1452-1458, 2020.0333-1024https://www.arca.fiocruz.br/handle/icict/4431210.1177/0333102420965963A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Clementino Fraga Filho University Hospital. Neurology Section. Rio de Janeiro, RJ, Brazil.Fluminense Federal University. Neurology Department. Niteroi, RJ, Brazil.Hospital Federal dos Servidores do Estado. Rio de Janeiro, RJ, Brazil.Eye Hospital. Niteroi, RJ, Brazil.Neurolife Laboratory. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil.Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of Respiratory Virus and Measles. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Rio de Janeiro, RJ, Brazil / Niteroi Hospital Complex. Neurology Department. Niteroi, RJ, Brazil / Federal University of Rio de Janeiro. Institute of Neurology. Rio de Janeiro, RJ, Brazil.Background: Headache is a frequent complaint in COVID-19 patients. However, no detailed information on headache characteristics is provided in these reports. Our objective is to describe the characteristics of headache and the cerebrospinal fluid (CSF) profile in COVID-19 patients, highlighting the cases of isolated intracranial hypertension. Methods: In this cross-sectional study, we selected COVID-19 patients who underwent lumbar puncture due to neurological complaints from April to May 2020. We reviewed clinical, imaging, and laboratory data of patients with refractory headache in the absence of other encephalitic or meningitic features. CSF opening pressures higher than 250 mmH2O were considered elevated, and from 200 to 250 mmH2O equivocal. Results: Fifty-six COVID-19 patients underwent lumbar puncture for different neurological conditions. A new, persistent headache that prompted a CSF analysis was diagnosed in 13 (23.2%). The pain was throbbing, holocranial or bilateral in the majority of patients. All patients had normal CSF analysis and RT-qPCR for SARS-CoV-2 was negative in all samples. Opening pressure >200 mmH2O was present in 11 patients and, in six of these, > 250 mmH2O. 6/13 patients had complete improvement of the pain, five had partial improvement, and two were left with a daily persistent headache. Conclusions: In a significant proportion of COVID-19 patients, headache was associated to intracranial hypertension in the absence of meningitic or encephalitic features. Coagulopathy associated with COVID-19 could be an explanation, but further studies including post-mortem analysis of areas of production and CSF absorption (choroid plexuses and arachnoid granulations) are necessary to clarify this issue.engSAGE PublicationsRede Genômica FiocruzGENOMAHCOVCOVID-19SARS-CoV-2Intracranial hypertensionPseudotumor cerebriHeadacheIsolated intracranial hypertension associated with COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Isolated intracranial hypertension associated with COVID-19 |
| title |
Isolated intracranial hypertension associated with COVID-19 |
| spellingShingle |
Isolated intracranial hypertension associated with COVID-19 Silva, Marcus Tulius T. Rede Genômica Fiocruz GENOMAHCOV COVID-19 SARS-CoV-2 Intracranial hypertension Pseudotumor cerebri Headache |
| title_short |
Isolated intracranial hypertension associated with COVID-19 |
| title_full |
Isolated intracranial hypertension associated with COVID-19 |
| title_fullStr |
Isolated intracranial hypertension associated with COVID-19 |
| title_full_unstemmed |
Isolated intracranial hypertension associated with COVID-19 |
| title_sort |
Isolated intracranial hypertension associated with COVID-19 |
| author |
Silva, Marcus Tulius T. |
| author_facet |
Silva, Marcus Tulius T. Lima, Marco A. Torezani, Guilherme Soares, Cristiane N. Dantas, Claudia Brandão, Carlos Otávio Espíndola, Otávio Siqueira, Marilda Agudo Mendonça Teixeira de Araujo, Abelardo Q. C. |
| author_role |
author |
| author2 |
Lima, Marco A. Torezani, Guilherme Soares, Cristiane N. Dantas, Claudia Brandão, Carlos Otávio Espíndola, Otávio Siqueira, Marilda Agudo Mendonça Teixeira de Araujo, Abelardo Q. C. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Marcus Tulius T. Lima, Marco A. Torezani, Guilherme Soares, Cristiane N. Dantas, Claudia Brandão, Carlos Otávio Espíndola, Otávio Siqueira, Marilda Agudo Mendonça Teixeira de Araujo, Abelardo Q. C. |
| dc.subject.other.pt_BR.fl_str_mv |
Rede Genômica Fiocruz GENOMAHCOV |
| topic |
Rede Genômica Fiocruz GENOMAHCOV COVID-19 SARS-CoV-2 Intracranial hypertension Pseudotumor cerebri Headache |
| dc.subject.en.pt_BR.fl_str_mv |
COVID-19 SARS-CoV-2 Intracranial hypertension Pseudotumor cerebri Headache |
| description |
A Rede Genômica Fiocruz é formada por especialistas de todas as unidades da Fundação no país e de institutos parceiros que se empenham diariamente em gerar dados mais robustos sobre o comportamento do SARS-Cov-2 e contribuir para um melhor preparo do país no enfrentamento da pandemia em termos de diagnóstico mais precisos e vacinas eficazes. Saiba mais sobre a Rede Genômica Fiocruz em: http://www.genomahcov.fiocruz.br/ |
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2020 |
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2020-11-04T22:54:20Z |
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2020-11-04T22:54:20Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SILVA, Marcus Tulius T. et al. Isolated intracranial hypertension associated with COVID-19. Cephalalgia, v. 40, n. 13, p. 1452-1458, 2020. |
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https://www.arca.fiocruz.br/handle/icict/44312 |
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0333-1024 |
| dc.identifier.doi.none.fl_str_mv |
10.1177/0333102420965963 |
| identifier_str_mv |
SILVA, Marcus Tulius T. et al. Isolated intracranial hypertension associated with COVID-19. Cephalalgia, v. 40, n. 13, p. 1452-1458, 2020. 0333-1024 10.1177/0333102420965963 |
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SAGE Publications |
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SAGE Publications |
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