Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study

Hitchings, Matt D. T.; Ranzani, Otavio T.; Torres, Mario Sergio Scaramuzzini; Oliveira, Silvano Barbosa de; Almiron, Maria; Said, Rodrigo; Borg, Ryan; Schulz, Wade L.; Oliveira, Roberto Dias de; Silva, Patricia Vieira da; Castro, Daniel Barros de; Sampaio, Vanderson de Souza; Albuquerque, Bernardino Cláudio de; Ramos, Tatyana Costa Amorim; Fraxe, Shadia Hussami Hauache; Costa, Cristiano Fernandes da; Naveca, Felipe Gomes; Siqueira, Andre M.; Araújo, Wildo Navegantes de; Andrews, Jason R.; Cummings, Derek A. T.; Ko, Albert I.; Croda, Julio

Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study

Detalhes bibliográficos
Autor(a) principal:	Hitchings, Matt D. T.
Data de Publicação:	2022
Outros Autores:	Ranzani, Otavio T., Torres, Mario Sergio Scaramuzzini, Oliveira, Silvano Barbosa de, Almiron, Maria, Said, Rodrigo, Borg, Ryan, Schulz, Wade L., Oliveira, Roberto Dias de, Silva, Patricia Vieira da, Castro, Daniel Barros de, Sampaio, Vanderson de Souza, Albuquerque, Bernardino Cláudio de, Ramos, Tatyana Costa Amorim, Fraxe, Shadia Hussami Hauache, Costa, Cristiano Fernandes da, Naveca, Felipe Gomes, Siqueira, Andre M., Araújo, Wildo Navegantes de, Andrews, Jason R., Cummings, Derek A. T., Ko, Albert I., Croda, Julio
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/52906
Resumo:	Fundação Oswaldo Cruz (Fiocruz); Municipal Health Secretary of Manaus; Fundação de Vigilância em Saúde do Amazonas.

Metadados do item

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spelling	Hitchings, Matt D. T.Ranzani, Otavio T.Torres, Mario Sergio ScaramuzziniOliveira, Silvano Barbosa deAlmiron, MariaSaid, RodrigoBorg, RyanSchulz, Wade L.Oliveira, Roberto Dias deSilva, Patricia Vieira daCastro, Daniel Barros deSampaio, Vanderson de SouzaAlbuquerque, Bernardino Cláudio deRamos, Tatyana Costa AmorimFraxe, Shadia Hussami HauacheCosta, Cristiano Fernandes daNaveca, Felipe GomesSiqueira, Andre M.Araújo, Wildo Navegantes deAndrews, Jason R.Cummings, Derek A. T.Ko, Albert I.Croda, Julio2022-05-25T23:18:57Z2022-05-25T23:18:57Z2022HITCHINGS, Matt D. T et al. Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study. Lancet Regional Health. Americas, v. 1, p. 1-19, 20222667-193Xhttps://www.arca.fiocruz.br/handle/icict/5290610.1016/j.lana.2021.100025Fundação Oswaldo Cruz (Fiocruz); Municipal Health Secretary of Manaus; Fundação de Vigilância em Saúde do Amazonas.University of Florida. Department of Biology. Gainesville, FL, USA / University of Florida. Emerging Pathogens Institute. Gainesville, FL, USA.Universidade de São Paulo. Faculdade de Medicina. Hospital das Clinicas HCFMUSP. Heart Institute (InCor). Pulmonary Division. São Paulo, SP, Brazil / ISGlobal. Barcelona Institute for Global Health. Barcelona, Spain.Municipal Health Secretary of Manaus. Manaus, AM, Brazil.Pan American Health Organization. Brasília, DF, Brazil / Universidade de Brasília. Brasília, DF, Brazil.Pan American Health Organization. Brasília, DF, Brazil.Pan American Health Organization. Brasília, DF, Brazil.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Yale-New Haven Hospital. Center for Outcomes Research and Evaluation. New Haven, CT, USA / Yale University School of Medicine. Department of Laboratory Medicine. New Haven, CT, USA.State University of Mato Grosso do Sul - UEMS. Dourados, MS, Brazil.Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande, MS, Brazil.Fundação de Vigilância em Saúde do Estado do Amazonas. Manaus, AM, Brazil.Fundação de Vigilância em Saúde do Estado do Amazonas. Manaus, AM, Brazil.Fundação de Vigilância em Saúde do Estado do Amazonas. Manaus, AM, Brazil.Fundação de Vigilância em Saúde do Estado do Amazonas. Manaus, AM, Brazil.Municipal Health Secretary of Manaus. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Pan American Health Organization. Brasília, DF, Brazil / Universidade de Brasília. Brasília, DF, Brazil / National Institute for Science and Technology for Health Technology Assessment. Porto Alegre, RS, Brazil.Stanford University. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, USA.University of Florida. Department of Biology. Gainesville, FL, USA / University of Florida. Emerging Pathogens Institute. Gainesville, FL, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Universidade Federal de Mato Grosso do Sul - UFMS. Campo Grande, MS, Brazil.Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, Gamma, emerged in the city of Manaus in late 2020 during a large resurgence of coronavirus disease (COVID-19), and has spread throughout Brazil. The effectiveness of vaccines in settings with widespread Gamma variant transmission has not been reported. Methods: We performed a matched test-negative case-control study to estimate the effectiveness of an inactivated vaccine, CoronaVac, in healthcare workers (HCWs) in Manaus, where the Gamma variant accounted for 86% of genotyped SARS-CoV-2 samples at the peak of its epidemic. We performed an early analysis of effectiveness following administration of at least one vaccine dose and an analysis of effectiveness of the two-dose schedule. The primary outcome was symptomatic SARS-CoV-2 infection. Findings: For the early at-least-one-dose and two-dose analyses the study population was, respectively, 53,176 and 53,153 HCWs residing in Manaus and aged 18 years or older, with complete information on age, residence, and vaccination status. Among 53,153 HCWs eligible for the two-dose analysis, 47,170 (89%) received at least one dose of CoronaVac and 2,656 individuals (5%) underwent RT-PCR testing from 19 January, 2021 to 13 April, 2021. Of 3,195 RT-PCR tests, 885 (28%) were positive. 393 and 418 case-control pairs were selected for the early and two-dose analyses, respectively, matched on calendar time, age, and neighbourhood. Among those who had received both vaccine doses before the RT-PCR sample collection date, the average time from second dose to sample collection date was 14 days (IQR 7-24). In the early analysis, vaccination with at least one dose was associated with a 0.50-fold reduction (adjusted vaccine effectiveness (VE), 49.6%, 95% CI 11.3 to 71.4) in the odds of symptomatic SARS-CoV-2 infection during the period 14 days or more after receiving the first dose. However, we estimated low effectiveness (adjusted VE 36.8%, 95% CI -54.9 to 74.2) of the two-dose schedule against symptomatic SARS-CoV-2 infection during the period 14 days or more after receiving the second dose. A finding that vaccinated individuals were much more likely to be infected than unvaccinated individuals in the period 0-13 days after first dose (aOR 2.11, 95% CI 1.36-3.27) suggests that unmeasured confounding led to downward bias in the vaccine effectiveness estimate. Interpretation: Evidence from this test-negative study of the effectiveness of CoronaVac was mixed, and likely affected by bias in this setting. Administration of at least one vaccine dose showed effectiveness against symptomatic SARS-CoV-2 infection in the setting of epidemic Gamma variant transmission. However, the low estimated effectiveness of the two-dose schedule underscores the need to maintain non-pharmaceutical interventions while vaccination campaigns with CoronaVac are being implemented.engElsevierEffectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrazilCOVID-19CoronaVacP.1 variantCase-control studyTest-negative studyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
title	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
spellingShingle	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study Hitchings, Matt D. T. Brazil COVID-19 CoronaVac P.1 variant Case-control study Test-negative study
title_short	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
title_full	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
title_fullStr	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
title_full_unstemmed	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
title_sort	Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study
author	Hitchings, Matt D. T.
author_facet	Hitchings, Matt D. T. Ranzani, Otavio T. Torres, Mario Sergio Scaramuzzini Oliveira, Silvano Barbosa de Almiron, Maria Said, Rodrigo Borg, Ryan Schulz, Wade L. Oliveira, Roberto Dias de Silva, Patricia Vieira da Castro, Daniel Barros de Sampaio, Vanderson de Souza Albuquerque, Bernardino Cláudio de Ramos, Tatyana Costa Amorim Fraxe, Shadia Hussami Hauache Costa, Cristiano Fernandes da Naveca, Felipe Gomes Siqueira, Andre M. Araújo, Wildo Navegantes de Andrews, Jason R. Cummings, Derek A. T. Ko, Albert I. Croda, Julio
author_role	author
author2	Ranzani, Otavio T. Torres, Mario Sergio Scaramuzzini Oliveira, Silvano Barbosa de Almiron, Maria Said, Rodrigo Borg, Ryan Schulz, Wade L. Oliveira, Roberto Dias de Silva, Patricia Vieira da Castro, Daniel Barros de Sampaio, Vanderson de Souza Albuquerque, Bernardino Cláudio de Ramos, Tatyana Costa Amorim Fraxe, Shadia Hussami Hauache Costa, Cristiano Fernandes da Naveca, Felipe Gomes Siqueira, Andre M. Araújo, Wildo Navegantes de Andrews, Jason R. Cummings, Derek A. T. Ko, Albert I. Croda, Julio
author2_role	author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Hitchings, Matt D. T. Ranzani, Otavio T. Torres, Mario Sergio Scaramuzzini Oliveira, Silvano Barbosa de Almiron, Maria Said, Rodrigo Borg, Ryan Schulz, Wade L. Oliveira, Roberto Dias de Silva, Patricia Vieira da Castro, Daniel Barros de Sampaio, Vanderson de Souza Albuquerque, Bernardino Cláudio de Ramos, Tatyana Costa Amorim Fraxe, Shadia Hussami Hauache Costa, Cristiano Fernandes da Naveca, Felipe Gomes Siqueira, Andre M. Araújo, Wildo Navegantes de Andrews, Jason R. Cummings, Derek A. T. Ko, Albert I. Croda, Julio
dc.subject.en.pt_BR.fl_str_mv	Brazil COVID-19 CoronaVac P.1 variant Case-control study Test-negative study
topic	Brazil COVID-19 CoronaVac P.1 variant Case-control study Test-negative study
description	Fundação Oswaldo Cruz (Fiocruz); Municipal Health Secretary of Manaus; Fundação de Vigilância em Saúde do Amazonas.
publishDate	2022
dc.date.accessioned.fl_str_mv	2022-05-25T23:18:57Z
dc.date.available.fl_str_mv	2022-05-25T23:18:57Z
dc.date.issued.fl_str_mv	2022
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	HITCHINGS, Matt D. T et al. Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study. Lancet Regional Health. Americas, v. 1, p. 1-19, 2022
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/52906
dc.identifier.issn.pt_BR.fl_str_mv	2667-193X
dc.identifier.doi.none.fl_str_mv	10.1016/j.lana.2021.100025
identifier_str_mv	HITCHINGS, Matt D. T et al. Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study. Lancet Regional Health. Americas, v. 1, p. 1-19, 2022 2667-193X 10.1016/j.lana.2021.100025
url	https://www.arca.fiocruz.br/handle/icict/52906
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/52906/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/52906/2/Effectiveness_Andre_Siqueira_etal_INI_2022_COVID-19.pdf
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bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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Effectiveness of CoronaVac among healthcare workers in the setting of high SARS-CoV-2 Gamma variant transmission in Manaus, Brazil: A test-negative case-control study

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