Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/29042 |
Resumo: | National Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USA / NIAID and Microbiology Service. Clinical Center. Bethesda, Maryland, USA. |
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Zelazny, Adrian M.Ding, LiElloumi, Houda Z.Brinster, Lauren R.Benedetti, FranCzapiga, MegganUlrich, Ricky L.Ballentine, Samuel J.Goldberg, Joanna B.Sampaio, Elizabeth P.Holland, Steven M.2018-09-25T15:23:56Z2018-09-25T15:23:56Z2009ZELAZNY, Adrian M. et al. Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease. Infection and Immunity, v.77, n.10, p.4337-4344, Oct. 2009.0019-9567https://www.arca.fiocruz.br/handle/icict/2904210.1128/IAI.00259-09engAmerican Society for MicrobiologyDoença granulomatosa crônicaVirulênciaInterações celularesBurkholderia multivoransChronic granulomatous diseaseVirulenceCellular InteractionsBurkholderia multivoransVirulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USA / NIAID and Microbiology Service. Clinical Center. Bethesda, Maryland, USA.National Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USANational Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USANational Institutes of Health. Division of Veterinary Research. Bethesda, Maryland, USA.National Institutes of Health. Division of Veterinary Research. Bethesda, Maryland, USA.National Institutes of Health. Biological Imaging Section. Bethesda, Maryland, USA.United States Army Medical Research Institute of Infectious Diseases. Bacteriology Division. Fort Detrick, Maryland, USA.National Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USAUniversity of Virginia Health System. Department of Microbiology. Charlottesville, Virignia, USA.National Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USA / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.National Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USAChronic granulomatous disease (CGD) patients are susceptible to life-threatening infections by the Burkholderia cepacia complex. We used leukocytes from CGD and healthy donors and compared cell association, invasion, and cytokine induction by Burkholderia multivorans strains. A CGD isolate, CGD1, showed higher cell association than that of an environmental isolate, Env1, which correlated with cell entry. All B. multivorans strains associated significantly more with cells from CGD patients than with those from healthy donors. Similar findings were observed with another CGD pathogen, Serratia marcescens, but not with Escherichia coli. In a mouse model of CGD, strain CGD1 was virulent while Env1 was avirulent. B. multivorans organisms were found in the spleens of CGD1-infected mice at levels that were 1,000 times higher than those found in Env1-infected mice, which was coincident with higher levels of the proinflammatory cytokine interleukin-1 . Taken together, these results may shed light on the unique susceptibility of CGD patients to specific pathogens.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29042/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALelisabeth_sampaio_etal_IOC_2009.pdfelisabeth_sampaio_etal_IOC_2009.pdfapplication/pdf2126248https://www.arca.fiocruz.br/bitstream/icict/29042/2/elisabeth_sampaio_etal_IOC_2009.pdf927167547248e2a458ca1e28b10c7e9aMD52TEXTelisabeth_sampaio_etal_IOC_2009.pdf.txtelisabeth_sampaio_etal_IOC_2009.pdf.txtExtracted texttext/plain40674https://www.arca.fiocruz.br/bitstream/icict/29042/3/elisabeth_sampaio_etal_IOC_2009.pdf.txtfc3ab9c765019fceee31e02a220b94c5MD53icict/290422018-09-26 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| dc.title.pt_BR.fl_str_mv |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease |
| title |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease |
| spellingShingle |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease Zelazny, Adrian M. Doença granulomatosa crônica Virulência Interações celulares Burkholderia multivorans Chronic granulomatous disease Virulence Cellular Interactions Burkholderia multivorans |
| title_short |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease |
| title_full |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease |
| title_fullStr |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease |
| title_full_unstemmed |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease |
| title_sort |
Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease |
| author |
Zelazny, Adrian M. |
| author_facet |
Zelazny, Adrian M. Ding, Li Elloumi, Houda Z. Brinster, Lauren R. Benedetti, Fran Czapiga, Meggan Ulrich, Ricky L. Ballentine, Samuel J. Goldberg, Joanna B. Sampaio, Elizabeth P. Holland, Steven M. |
| author_role |
author |
| author2 |
Ding, Li Elloumi, Houda Z. Brinster, Lauren R. Benedetti, Fran Czapiga, Meggan Ulrich, Ricky L. Ballentine, Samuel J. Goldberg, Joanna B. Sampaio, Elizabeth P. Holland, Steven M. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Zelazny, Adrian M. Ding, Li Elloumi, Houda Z. Brinster, Lauren R. Benedetti, Fran Czapiga, Meggan Ulrich, Ricky L. Ballentine, Samuel J. Goldberg, Joanna B. Sampaio, Elizabeth P. Holland, Steven M. |
| dc.subject.other.pt_BR.fl_str_mv |
Doença granulomatosa crônica Virulência Interações celulares Burkholderia multivorans |
| topic |
Doença granulomatosa crônica Virulência Interações celulares Burkholderia multivorans Chronic granulomatous disease Virulence Cellular Interactions Burkholderia multivorans |
| dc.subject.en.pt_BR.fl_str_mv |
Chronic granulomatous disease Virulence Cellular Interactions Burkholderia multivorans |
| description |
National Institutes of Health. Laboratory of Clinical Infectious Diseases. Bethesda, Maryland, USA / NIAID and Microbiology Service. Clinical Center. Bethesda, Maryland, USA. |
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2009 |
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2009 |
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2018-09-25T15:23:56Z |
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2018-09-25T15:23:56Z |
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info:eu-repo/semantics/article |
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ZELAZNY, Adrian M. et al. Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease. Infection and Immunity, v.77, n.10, p.4337-4344, Oct. 2009. |
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https://www.arca.fiocruz.br/handle/icict/29042 |
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0019-9567 |
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10.1128/IAI.00259-09 |
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ZELAZNY, Adrian M. et al. Virulence and Cellular Interactions of Burkholderia multivorans in Chronic Granulomatous Disease. Infection and Immunity, v.77, n.10, p.4337-4344, Oct. 2009. 0019-9567 10.1128/IAI.00259-09 |
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American Society for Microbiology |
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