Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population

Detalhes bibliográficos
Autor(a) principal: Sá, Renata Almeida de
Data de Publicação: 2014
Outros Autores: Moreyra, Aline dos Santos, Cabello, Pedro Herman, Ornellas, Antonio Augusto, Costa, Eduardo Butinhão, Matos, Cintia da Silva, Alves, Gilda, Hatagima, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10393
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Laboratório de Genética Aplicada. Serviço de Hematologia. Rio de Janeiro, RJ, Brasil.
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spelling Sá, Renata Almeida deMoreyra, Aline dos SantosCabello, Pedro HermanOrnellas, Antonio AugustoCosta, Eduardo ButinhãoMatos, Cintia da SilvaAlves, GildaHatagima, Ana2015-05-19T13:26:03Z2015-05-19T13:26:03Z2014SÁ, Renata Almeida de; et al.Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population. International braz j urol, v.40, n.4, p.463-473, jul - aug. 2014.1677-5538https://www.arca.fiocruz.br/handle/icict/1039310.1590/S1677-5538.IBJU.2014.04.04engSociedade Brasileira de UrologiaHuman glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Laboratório de Genética Aplicada. Serviço de Hematologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio (UNIGRANRIO). Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Serviço de Urologia. Rio de Janeiro, RJ, Brasil / Hospital Mário Kröeff. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio deJaneiro, RJ, Brasil.Instituto Nacional de Câncer. Laboratório de Genética Aplicada. Serviço de Hematologia. Laboratório de Patologia Clínica. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer. Laboratório de Genética Aplicada. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.Objective: To evaluate the influence of polymorphisms in GSTA1, GSTM1, GSTT1, and GSTP1 in the risk of developing Prostate Cancer (PCa) in a population of Rio de Janeiro and compare the distribution of allele and genotype frequencies of the polymorphisms analyzed in the present study population with other regions in the country and different ethnic groups. Materials and Methods: We analyzed a sample of the Brazilian population, comprising 196 patients with PCa treated by the urology services of the Brazilian National Cancer Institute (INCA) and Mario Kroeff Hospital (HMK), and 208 male blood donors from the Clementino Fraga Filho Hospital, Federal University of Rio de Janeiro (UFRJ). The polymorphisms were determined in DNA, extracted from peripheral blood leucocytes using the Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Our results showed that the distribution of polymorphisms can vary significantly according to the Brazilian region and ethnic groups. The distribution of allele and genotype frequencies of the polymorphism GSTA1 was statistically different between cases and controls. Genotypes (A / B + B / B) were associated with protection (OR = 0.61, 95 % CI = 0.40-0.92) for PCa in comparison to genotype A / A. Conclusion: The distribution of genotype frequencies of the polymorphism GSTA1 was statistically different between the case and control groups (p = 0.023), and the presence of genotypes A / B and B / B suggests a protective role against the risk of PCa compared to genotype A / A. This is the first study that reports the genotypic frequency of this polymorphism and its association with PCa in a Brazilian population sample.Population GroupsProstatic NeoplasmsDisease SusceptibilityGlutathioneGlutationaSuscetibilidade a DoençasNeoplasias da PróstataPopulation Groupsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10393/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALrenata_saetal_IOC_2014.pdfapplication/pdf619362https://www.arca.fiocruz.br/bitstream/icict/10393/2/renata_saetal_IOC_2014.pdf249a56713901d74074a95ef6b1baae74MD52TEXTrenata_saetal_IOC_2014.pdf.txtrenata_saetal_IOC_2014.pdf.txtExtracted texttext/plain36397https://www.arca.fiocruz.br/bitstream/icict/10393/3/renata_saetal_IOC_2014.pdf.txt43494eea1d0b68509934fdcb9c6a18bcMD53icict/103932022-06-24 13:10:47.533oai:www.arca.fiocruz.br:icict/10393TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
title Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
spellingShingle Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
Sá, Renata Almeida de
Population Groups
Prostatic Neoplasms
Disease Susceptibility
Glutathione
Glutationa
Suscetibilidade a Doenças
Neoplasias da Próstata
Population Groups
title_short Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
title_full Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
title_fullStr Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
title_full_unstemmed Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
title_sort Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population
author Sá, Renata Almeida de
author_facet Sá, Renata Almeida de
Moreyra, Aline dos Santos
Cabello, Pedro Herman
Ornellas, Antonio Augusto
Costa, Eduardo Butinhão
Matos, Cintia da Silva
Alves, Gilda
Hatagima, Ana
author_role author
author2 Moreyra, Aline dos Santos
Cabello, Pedro Herman
Ornellas, Antonio Augusto
Costa, Eduardo Butinhão
Matos, Cintia da Silva
Alves, Gilda
Hatagima, Ana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sá, Renata Almeida de
Moreyra, Aline dos Santos
Cabello, Pedro Herman
Ornellas, Antonio Augusto
Costa, Eduardo Butinhão
Matos, Cintia da Silva
Alves, Gilda
Hatagima, Ana
dc.subject.en.pt_BR.fl_str_mv Population Groups
Prostatic Neoplasms
Disease Susceptibility
Glutathione
topic Population Groups
Prostatic Neoplasms
Disease Susceptibility
Glutathione
Glutationa
Suscetibilidade a Doenças
Neoplasias da Próstata
Population Groups
dc.subject.decs.pt_BR.fl_str_mv Glutationa
Suscetibilidade a Doenças
Neoplasias da Próstata
Population Groups
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Câncer. Laboratório de Genética Aplicada. Serviço de Hematologia. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-05-19T13:26:03Z
dc.date.available.fl_str_mv 2015-05-19T13:26:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SÁ, Renata Almeida de; et al.Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population. International braz j urol, v.40, n.4, p.463-473, jul - aug. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10393
dc.identifier.issn.pt_BR.fl_str_mv 1677-5538
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S1677-5538.IBJU.2014.04.04
identifier_str_mv SÁ, Renata Almeida de; et al.Human glutathione S-transferase polymorphisms associated with prostate cancer in the Brazilian population. International braz j urol, v.40, n.4, p.463-473, jul - aug. 2014.
1677-5538
10.1590/S1677-5538.IBJU.2014.04.04
url https://www.arca.fiocruz.br/handle/icict/10393
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedade Brasileira de Urologia
publisher.none.fl_str_mv Sociedade Brasileira de Urologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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