Antibodies to citrullinated peptides in tuberculosis

Detalhes bibliográficos
Autor(a) principal: Lima, Isabella Vargas de Souza
Data de Publicação: 2013
Outros Autores: Oliveira, Rodrigo Carvalho de, Atta, Ajax Mercês, Marchi, S, Barbosa, Lúcio Macedo, Reis, Eliana Almeida Gomes, Reis, Mitermayer Galvão dos, Santiago, Mitermayer Barreto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1007/s10067-013-2173-y
Texto Completo: https://www.arca.fiocruz.br/handle/icict/14983
Resumo: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
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spelling Lima, Isabella Vargas de SouzaOliveira, Rodrigo Carvalho deAtta, Ajax MercêsMarchi, SBarbosa, Lúcio MacedoReis, Eliana Almeida GomesReis, Mitermayer Galvão dosSantiago, Mitermayer Barreto2016-07-19T18:18:21Z2016-07-19T18:18:21Z2013LIMA, I. V. S. Antibodies to citrullinated peptides in tuberculosis. ClinIcal Rheumatology, v. 32, p. 685–687, 2013.0770-3198https://www.arca.fiocruz.br/handle/icict/1498310.1007/s10067-013-2173-yengSpringer VerlagAntibodies to citrullinated peptides in tuberculosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilUniversidade Federal da Bahia. Faculdade de Farmácia. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Gonçalo Moniz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilServiços Especializados em Reumatologia da Bahia. Salvador, BA, BrasilRheumatoid arthritis (RA) is an autoimmune disease characterized by symmetric polyarthritis, rheumatoid factor (RF) positivity, and bone erosions. Recently, research has been conducted on anti-citrullinated peptide antibodies (ACPAs) to which there are greater sensitivity and specificity than RF. However, these antibodies have also been described in infectious diseases, particularly tuberculosis (TB), placing the high specificity of the test in doubt. The aim of this research was to study the prevalence of ACPAs in TB, RA, and healthy controls. Patients with bacteriologically confirmed pulmonary tuberculosis, RA (ACR criteria), in addition to healthy controls were included. ACPAs were researched by: anti-cyclic citrullinated peptide (CCP), anti-modified citrullinated vimentin (MCV), and RF by ELISA. The study was conducted in 50 TB patients, 50 with RA, and 20 controls. Anti-CCP antibodies were found in 39 (78 %) of the RA patients (median titer, 128 U), whereas anti-MCV antibodies were found in 25 (50 %). Of the patients with TB, two (4 %) had positivity for anti-CCP and anti-MCV and no patient in the control group tested positive for these antibodies. Sensitivity of anti-CCP for RA was 78 % (confidence interval (CI), 63 to 88 %) and specificity was 97 % (CI, 89 to 99 %) while the sensitivity of anti-MCV was 50 % (CI, 35-64 %) and specificity was 97 % (CI, 89 to 99 %). RF was positive in 40 samples (80 %) of RA, in 30 (60 %) of TB, and in 1 (5 %) of the controls. Our findings showed high sensitivity of anti-CCP and high specificity of both anti-CCP and anti-MCV antibodies for RA, even in a population with high incidence of tuberculosis. The higher frequency of positivity of ACPA in TB observed in previous studies may be attributed to methodological factors.ACPAAnti-CCPAnti-MCVRheumatoid arthritisRheumatoid factorTuberculosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14983/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLima I Antibodies....pdfLima I Antibodies....pdfapplication/pdf93234https://www.arca.fiocruz.br/bitstream/icict/14983/2/Lima%20I%20Antibodies....pdf3bc5103681fdb9d6bef0ac8b797d712aMD52TEXTLima I Antibodies....pdf.txtLima I Antibodies....pdf.txtExtracted texttext/plain14422https://www.arca.fiocruz.br/bitstream/icict/14983/3/Lima%20I%20Antibodies....pdf.txtc3c97a39769ae220c221aa4c5b7cc40aMD53icict/149832023-03-15 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dc.title.pt_BR.fl_str_mv Antibodies to citrullinated peptides in tuberculosis
title Antibodies to citrullinated peptides in tuberculosis
spellingShingle Antibodies to citrullinated peptides in tuberculosis
Lima, Isabella Vargas de Souza
ACPA
Anti-CCP
Anti-MCV
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
title_short Antibodies to citrullinated peptides in tuberculosis
title_full Antibodies to citrullinated peptides in tuberculosis
title_fullStr Antibodies to citrullinated peptides in tuberculosis
title_full_unstemmed Antibodies to citrullinated peptides in tuberculosis
title_sort Antibodies to citrullinated peptides in tuberculosis
author Lima, Isabella Vargas de Souza
author_facet Lima, Isabella Vargas de Souza
Oliveira, Rodrigo Carvalho de
Atta, Ajax Mercês
Marchi, S
Barbosa, Lúcio Macedo
Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Santiago, Mitermayer Barreto
author_role author
author2 Oliveira, Rodrigo Carvalho de
Atta, Ajax Mercês
Marchi, S
Barbosa, Lúcio Macedo
Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Santiago, Mitermayer Barreto
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Isabella Vargas de Souza
Oliveira, Rodrigo Carvalho de
Atta, Ajax Mercês
Marchi, S
Barbosa, Lúcio Macedo
Reis, Eliana Almeida Gomes
Reis, Mitermayer Galvão dos
Santiago, Mitermayer Barreto
dc.subject.en.pt_BR.fl_str_mv ACPA
Anti-CCP
Anti-MCV
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
topic ACPA
Anti-CCP
Anti-MCV
Rheumatoid arthritis
Rheumatoid factor
Tuberculosis
description Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2016-07-19T18:18:21Z
dc.date.available.fl_str_mv 2016-07-19T18:18:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, I. V. S. Antibodies to citrullinated peptides in tuberculosis. ClinIcal Rheumatology, v. 32, p. 685–687, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14983
dc.identifier.issn.pt_BR.fl_str_mv 0770-3198
dc.identifier.doi.none.fl_str_mv 10.1007/s10067-013-2173-y
identifier_str_mv LIMA, I. V. S. Antibodies to citrullinated peptides in tuberculosis. ClinIcal Rheumatology, v. 32, p. 685–687, 2013.
0770-3198
10.1007/s10067-013-2173-y
url https://www.arca.fiocruz.br/handle/icict/14983
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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