Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study

Detalhes bibliográficos
Autor(a) principal: Lamas, Cristiane C.
Data de Publicação: 2017
Outros Autores: Coelho, Lara E., Grinsztejn, Beatriz, Veloso, Valdiléa G.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/25431
Resumo: 2018-06-30
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spelling Lamas, Cristiane C.Coelho, Lara E.Grinsztejn, BeatrizVeloso, Valdiléa G.2018-03-20T16:04:07Z2018-03-20T16:04:07Z2017LAMAS, Cristiane C. et al. Community‑acquired lower respiratory tract infections in HIV‑infected patients on antiretroviral therapy: predictors in a contemporary cohort study. Infection, v. 45, n. 6, p. 801-809, June 2017.0300-8126https://www.arca.fiocruz.br/handle/icict/2543110.1007/s15010-017-1041-0porSpringerSíndrome de Imunodeficiência AdquiridaAIDSHIVVacinaçãoVaccinationAIDSCommunity-acquired pneumoniaAntiretroviral therapyVaccinationAcquired Immunodeficiency SyndromeCommunity-Acquired InfectionsCommunity-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-06-30Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Community-acquired pneumonia represents the most frequent bacterial infection in patients with HIV/AIDS. Purpose We aimed to assess variables associated with lower respiratory tract infection (LRTI) among HIVinfected adults using ART. Methods A cohort study of HIV-infected patients aged ≥18 years, enrolled from 2000 to 2015, on ART for at least 60 days, with primary outcome as the 1st episode of LRTI during follow-up. The independent variables included were sex at birth, age, race/skin color, educational level, tobacco smoking, alcohol use, cocaine use, diabetes mellitus, CD4 count, HIV viral load, infuenza and pneumococcal vaccination. Extended Cox proportional hazards models accounting for time-updated variables were ftted to assess LRTI predictors. Results 2669 patients were included; median followup was 3.9 years per patient. LRTI was diagnosed in 384 patients; incidence rate was 30.7/1000 PY. In the unadjusted Cox extended models, non-white race [crude hazard ratio (cHR) 1.28, p = 0.020], cocaine use (cHR 2.01, p < 0.001), tobacco smoking (cHR 1.34, p value 0.007), and HIV viral load ≥400 copies/mL (cHR 3.40, p < 0.001) increased the risk of LRTI. Lower risk of LRTI was seen with higher educational level (cHR 0.61, p < 0.001), rise in CD4 counts (cHR 0.81, p < 0.001, per 100 cells/mm3 increase), infuenza (cHR 0.60, p = 0.002) and pneumococcal vaccination (cHR 0.57, p < 0.001). In the adjusted model, aHR for CD4 count was 0.86, for cocaine use 1.47 and for viral load ≥400 copies 2.20. Conclusions LRTI has a high incidence in HIV-infected adults using ART. Higher CD4 counts and undetectable viral loads were protective, as were pneumococcal and infuenza vaccines.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/25431/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALCommunity-acquired lower respiratory tract infections in HIV-infected patients.pdfCommunity-acquired lower respiratory tract infections in HIV-infected patients.pdfapplication/pdf469293https://www.arca.fiocruz.br/bitstream/icict/25431/2/Community-acquired%20lower%20respiratory%20tract%20infections%20in%20HIV-infected%20patients.pdf705ae39070ac3a5b7ba6f3246fbcb69eMD52TEXTCommunity-acquired lower respiratory tract infections in HIV-infected patients.pdf.txtCommunity-acquired lower respiratory tract infections in HIV-infected patients.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
title Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
spellingShingle Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
Lamas, Cristiane C.
Síndrome de Imunodeficiência Adquirida
AIDS
HIV
Vacinação
Vaccination
AIDS
Community-acquired pneumonia
Antiretroviral therapy
Vaccination
Acquired Immunodeficiency Syndrome
Community-Acquired Infections
title_short Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
title_full Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
title_fullStr Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
title_full_unstemmed Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
title_sort Community-acquired lower respiratory tract infections in HIV-infected patients on antiretroviral therapy: predictors in a contemporary cohort study
author Lamas, Cristiane C.
author_facet Lamas, Cristiane C.
Coelho, Lara E.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
author_role author
author2 Coelho, Lara E.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
author2_role author
author
author
dc.contributor.author.fl_str_mv Lamas, Cristiane C.
Coelho, Lara E.
Grinsztejn, Beatriz
Veloso, Valdiléa G.
dc.subject.other.pt_BR.fl_str_mv Síndrome de Imunodeficiência Adquirida
AIDS
HIV
Vacinação
topic Síndrome de Imunodeficiência Adquirida
AIDS
HIV
Vacinação
Vaccination
AIDS
Community-acquired pneumonia
Antiretroviral therapy
Vaccination
Acquired Immunodeficiency Syndrome
Community-Acquired Infections
dc.subject.en.pt_BR.fl_str_mv Vaccination
AIDS
Community-acquired pneumonia
Antiretroviral therapy
dc.subject.decs.pt_BR.fl_str_mv Vaccination
Acquired Immunodeficiency Syndrome
Community-Acquired Infections
description 2018-06-30
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2018-03-20T16:04:07Z
dc.date.available.fl_str_mv 2018-03-20T16:04:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LAMAS, Cristiane C. et al. Community‑acquired lower respiratory tract infections in HIV‑infected patients on antiretroviral therapy: predictors in a contemporary cohort study. Infection, v. 45, n. 6, p. 801-809, June 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/25431
dc.identifier.issn.pt_BR.fl_str_mv 0300-8126
dc.identifier.doi.none.fl_str_mv 10.1007/s15010-017-1041-0
identifier_str_mv LAMAS, Cristiane C. et al. Community‑acquired lower respiratory tract infections in HIV‑infected patients on antiretroviral therapy: predictors in a contemporary cohort study. Infection, v. 45, n. 6, p. 801-809, June 2017.
0300-8126
10.1007/s15010-017-1041-0
url https://www.arca.fiocruz.br/handle/icict/25431
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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