A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1981 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20379 |
Resumo: | Organização Pan-Americana da Saúde e Indústria e Comercio S.A. (ICOMI). |
| id |
CRUZ_589a45ae3c20900ffd0e5e591ec4da1f |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/20379 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Sleigh, Adrian CMott, Kenneth ESilva, J. T. FrançaMuniz, Tácito MMota, Eduardo Luiz AndradeBarreto, Maurício LimaHoff, RodneyMaguire, James HLehman, J. SSherlock, Ítalo Rodrigues de Araújo2017-07-24T17:32:10Z2017-07-24T17:32:10Z1981SLEIGH, A. C. et al. A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 75, n. 2, p. 234-238, 1981.0035-9203https://www.arca.fiocruz.br/handle/icict/20379Organização Pan-Americana da Saúde e Indústria e Comercio S.A. (ICOMI).Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAHarvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of Bahia. Salvador, BA, BrazilUniversidade Federal da Bahia. Departamento de Medicina Preventiva. Salvador, BA, BrasilHarvard School of Public Health. Department of Tropical Public Health. Boston, MA, USAHarvard School of Public Health. Department of Tropical Public Health. Boston, MA, USASem afiliaçãoFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilOral oxamniquine was tested as a control strategy for endemic schistosomiasis in a rural area of Bahia, Brazil. Adults were treated with a single dose (12 * 5 to 15 mg per kg) and children ( < 12 years old) with a total of 20 mg per kg in two doses. The 191 (infected) persons treated represented 69% of the infected population in the study area. Follow-up stool examinations (Kato-Katz method) at one, 3, 6,13,25 and 33 months showed the cure rate declining from 80% at three months to 46% at 33 months. Over one half of those not cured showed a decrease in egg counts throughout the follow-up which, after 33 months, remained 66% below the pre-treatment levels. Stool examinations conducted on all study area residents during three years before chemotherapy showed the prevalence and intensity of Schistosoma mansoni infection to be high and stable. 33 months after the chemotherapy the prevalence was 41% and for infected individuals the geometric mean egg count was 121 epg, a decline of respectively 35y0 and 4074 from pre-treatment levels for each index. Chemotherapy of infected persons with oxamniquine protected the community as a whole from high worm burdens for almost three years, although at this point the prevalence began to rise towards pretreatment levels.engOxford University PressEsquistossomose mansoniQuimioterapiaOxamniquinePrevalênciaHumanosTratamentoSchistosomiasis mansoniChemotherapyOxamniquinePrevalenceHumansTreatmentA three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20379/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSleigh A A three year follow up .....pdfSleigh A A three year follow up .....pdfapplication/pdf470093https://www.arca.fiocruz.br/bitstream/icict/20379/2/Sleigh%20A%20A%20three%20year%20follow%20up%20.....pdf2149b823264afefafdd02f65f1c685ecMD52TEXTSleigh A A three year follow up .....pdf.txtSleigh A A three year follow up .....pdf.txtExtracted texttext/plain18992https://www.arca.fiocruz.br/bitstream/icict/20379/3/Sleigh%20A%20A%20three%20year%20follow%20up%20.....pdf.txt1745a10a622f987cc5cb8aeef0e27592MD53icict/203792023-03-15 14:33:53.543oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni |
| title |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni |
| spellingShingle |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni Sleigh, Adrian C Esquistossomose mansoni Quimioterapia Oxamniquine Prevalência Humanos Tratamento Schistosomiasis mansoni Chemotherapy Oxamniquine Prevalence Humans Treatment |
| title_short |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni |
| title_full |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni |
| title_fullStr |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni |
| title_full_unstemmed |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni |
| title_sort |
A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni |
| author |
Sleigh, Adrian C |
| author_facet |
Sleigh, Adrian C Mott, Kenneth E Silva, J. T. França Muniz, Tácito M Mota, Eduardo Luiz Andrade Barreto, Maurício Lima Hoff, Rodney Maguire, James H Lehman, J. S Sherlock, Ítalo Rodrigues de Araújo |
| author_role |
author |
| author2 |
Mott, Kenneth E Silva, J. T. França Muniz, Tácito M Mota, Eduardo Luiz Andrade Barreto, Maurício Lima Hoff, Rodney Maguire, James H Lehman, J. S Sherlock, Ítalo Rodrigues de Araújo |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sleigh, Adrian C Mott, Kenneth E Silva, J. T. França Muniz, Tácito M Mota, Eduardo Luiz Andrade Barreto, Maurício Lima Hoff, Rodney Maguire, James H Lehman, J. S Sherlock, Ítalo Rodrigues de Araújo |
| dc.subject.other.pt_BR.fl_str_mv |
Esquistossomose mansoni Quimioterapia Oxamniquine Prevalência Humanos Tratamento |
| topic |
Esquistossomose mansoni Quimioterapia Oxamniquine Prevalência Humanos Tratamento Schistosomiasis mansoni Chemotherapy Oxamniquine Prevalence Humans Treatment |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosomiasis mansoni Chemotherapy Oxamniquine Prevalence Humans Treatment |
| description |
Organização Pan-Americana da Saúde e Indústria e Comercio S.A. (ICOMI). |
| publishDate |
1981 |
| dc.date.issued.fl_str_mv |
1981 |
| dc.date.accessioned.fl_str_mv |
2017-07-24T17:32:10Z |
| dc.date.available.fl_str_mv |
2017-07-24T17:32:10Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
SLEIGH, A. C. et al. A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 75, n. 2, p. 234-238, 1981. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/20379 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0035-9203 |
| identifier_str_mv |
SLEIGH, A. C. et al. A three year follow-up of chemotherapy with oxamniquine in a Brazilian community with endemic schistosomiasis mansoni. Transactions of The Royal Society of Tropical Medicine and Hygiene, v. 75, n. 2, p. 234-238, 1981. 0035-9203 |
| url |
https://www.arca.fiocruz.br/handle/icict/20379 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Oxford University Press |
| publisher.none.fl_str_mv |
Oxford University Press |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/20379/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/20379/2/Sleigh%20A%20A%20three%20year%20follow%20up%20.....pdf https://www.arca.fiocruz.br/bitstream/icict/20379/3/Sleigh%20A%20A%20three%20year%20follow%20up%20.....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 2149b823264afefafdd02f65f1c685ec 1745a10a622f987cc5cb8aeef0e27592 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009231885893632 |