Activity of Brazilian and Bulgarian propolis against different species of Leishmania

Detalhes bibliográficos
Autor(a) principal: Machado, Gérzia Maria de Carvalho
Data de Publicação: 2007
Outros Autores: Leon, Leonor Laura, Castro, Solange Lisboa de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35839
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.
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spelling Machado, Gérzia Maria de CarvalhoLeon, Leonor LauraCastro, Solange Lisboa de2019-09-24T13:25:39Z2019-09-24T13:25:39Z2007MACHADO, Gérzia Maria de Carvalho; LEON, Leonor Laura; CASTRO, Solange Lisboa de. Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 1, p. 73-77, Feb. 2007.0074-0276https://www.arca.fiocruz.br/handle/icict/3583910.1590/s0074-027620070001000121678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzLeishmaniaLeishmaniosePrópolisProdutos naturaisComposição químicaLeishmaniaLeishmaniasisPropolisChemical compositionNatural productsActivity of Brazilian and Bulgarian propolis against different species of Leishmaniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-estrutura e Biologia Celular. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Extracts of propolis samples collected in Brazil and Bulgaria were assayed against four Leishmania species--Leishmania amazonensis, L. braziliensis, L. chagasi from the New World, and L. major from the Old World--associated to different clinical forms of leishmaniasis. The composition of the extracts has been previously characterized by high temperature high resolution gas chromatography coupled to mass spectrometry. Considering the chemical differences among the extracts and the behavior of the parasites, it was observed significant differences in the leishmanicidal activities with IC50/1 day values in the range of 2.8 to 229.3 microg/ml . An overall analysis showed that for all the species evaluated, Bulgarian extracts were more active than the ethanol Brazilian extract. As the assayed propolis extracts have their chemical composition determined it merits further investigation the effect of individual components or their combinations on each Leishmania species.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35839/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSolangeLCastro_Leonorleon_etal_IOC_2007.pdfSolangeLCastro_Leonorleon_etal_IOC_2007.pdfapplication/pdf198808https://www.arca.fiocruz.br/bitstream/icict/35839/2/SolangeLCastro_Leonorleon_etal_IOC_2007.pdf788503db1a3811bd84403d9266bff05bMD52TEXTSolangeLCastro_Leonorleon_etal_IOC_2007.pdf.txtSolangeLCastro_Leonorleon_etal_IOC_2007.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Activity of Brazilian and Bulgarian propolis against different species of Leishmania
title Activity of Brazilian and Bulgarian propolis against different species of Leishmania
spellingShingle Activity of Brazilian and Bulgarian propolis against different species of Leishmania
Machado, Gérzia Maria de Carvalho
Leishmania
Leishmaniose
Própolis
Produtos naturais
Composição química
Leishmania
Leishmaniasis
Propolis
Chemical composition
Natural products
title_short Activity of Brazilian and Bulgarian propolis against different species of Leishmania
title_full Activity of Brazilian and Bulgarian propolis against different species of Leishmania
title_fullStr Activity of Brazilian and Bulgarian propolis against different species of Leishmania
title_full_unstemmed Activity of Brazilian and Bulgarian propolis against different species of Leishmania
title_sort Activity of Brazilian and Bulgarian propolis against different species of Leishmania
author Machado, Gérzia Maria de Carvalho
author_facet Machado, Gérzia Maria de Carvalho
Leon, Leonor Laura
Castro, Solange Lisboa de
author_role author
author2 Leon, Leonor Laura
Castro, Solange Lisboa de
author2_role author
author
dc.contributor.author.fl_str_mv Machado, Gérzia Maria de Carvalho
Leon, Leonor Laura
Castro, Solange Lisboa de
dc.subject.other.pt_BR.fl_str_mv Leishmania
Leishmaniose
Própolis
Produtos naturais
Composição química
topic Leishmania
Leishmaniose
Própolis
Produtos naturais
Composição química
Leishmania
Leishmaniasis
Propolis
Chemical composition
Natural products
dc.subject.en.pt_BR.fl_str_mv Leishmania
Leishmaniasis
Propolis
Chemical composition
Natural products
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Bioquímica de Tripanossomatídeos. Rio de Janeiro, RJ. Brasil.
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2019-09-24T13:25:39Z
dc.date.available.fl_str_mv 2019-09-24T13:25:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MACHADO, Gérzia Maria de Carvalho; LEON, Leonor Laura; CASTRO, Solange Lisboa de. Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 1, p. 73-77, Feb. 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35839
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/s0074-02762007000100012
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv MACHADO, Gérzia Maria de Carvalho; LEON, Leonor Laura; CASTRO, Solange Lisboa de. Activity of Brazilian and Bulgarian propolis against different species of Leishmania. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 102, n. 1, p. 73-77, Feb. 2007.
0074-0276
10.1590/s0074-02762007000100012
1678-8060
url https://www.arca.fiocruz.br/handle/icict/35839
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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