Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/11488 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
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Almeida, Vinicius Cotta deDupré, LöicGuipouy, DelphineVasconcelos, Zilton Farias Meira de2015-08-19T13:49:20Z2015-08-19T13:49:20Z2015ALMEIDA, Vinicius Cotta de et al. Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome. Frontiers in Immunology, v. 6, Article 47, p. 1-11, Feb. 2015.1664-3224https://www.arca.fiocruz.br/handle/icict/1148810.3389/fimmu.2015.00047engUniversity of WashingtonTranscriçãoComunicaçãoWiskott–Aldrich syndromeT lymphocytesActin cytoskeletonMotilityImmunological synapseSignalingTranscriptionCitoesqueleto de ActinaMotilidadeLinfócitos TCitoesqueleto de ActinaSignal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.UMR 1043, Centre de Physiopathologie de Toulouse Purpan. INSERM. Toulouse, France / Université Toulouse III Paul-Sabatier. Toulouse, France / UMR 5282, CNRS. Toulouse, France.UMR 1043, Centre de Physiopathologie de Toulouse Purpan. INSERM. Toulouse, France / Université Toulouse III Paul-Sabatier. Toulouse, France / UMR 5282, CNRS. Toulouse, France.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Over the last decades, research dedicated to the molecular and cellular mechanisms underlying primary immunodeficiencies (PID) has helped to understand the etiology of many of these diseases and to develop novel therapeutic approaches. Beyond these aspects, PID are also studied because they offer invaluable natural genetic tools to dissect the human immune system. In this review, we highlight the research that has focused over the last 20 years on T lymphocytes fromWiskott–Aldrich syndrome (WAS) patients.WAS T lymphocytes are defective for the WAS protein (WASP), a regulator of actin cytoskeleton remodeling. Therefore, study of WAS T lymphocytes has helped to grasp that many steps of T lymphocyte activation and function depend on the crosstalk between membrane receptors and the actin cytoskeleton. These steps include motility, immunological synapse assembly, and signaling, as well as the implementation of helper, regulatory, or cytotoxic effector functions. The recent concept that WASP also works as a regulator of transcription within the nucleus is an illustration of the complexity of signal integration in T lymphocytes. Finally, this review will discuss howfurther study ofWAS may contribute to solve novel challenges of T lymphocyte biology.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11488/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALvinicius_almeida_etal_IOC-2015.pdfapplication/pdf1082183https://www.arca.fiocruz.br/bitstream/icict/11488/2/vinicius_almeida_etal_IOC-2015.pdf93e3b426efdf1ea400c869adeed7545fMD52TEXTvinicius_almeida_etal_IOC-2015.pdf.txtvinicius_almeida_etal_IOC-2015.pdf.txtExtracted texttext/plain70557https://www.arca.fiocruz.br/bitstream/icict/11488/3/vinicius_almeida_etal_IOC-2015.pdf.txt18eeb854a357018fe2d09dd97cb088b5MD53icict/114882022-06-24 12:17:33.017oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T15:17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome |
| title |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome |
| spellingShingle |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome Almeida, Vinicius Cotta de Transcrição Comunicação Wiskott–Aldrich syndrome T lymphocytes Actin cytoskeleton Motility Immunological synapse Signaling Transcription Citoesqueleto de Actina Motilidade Linfócitos T Citoesqueleto de Actina |
| title_short |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome |
| title_full |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome |
| title_fullStr |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome |
| title_full_unstemmed |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome |
| title_sort |
Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome |
| author |
Almeida, Vinicius Cotta de |
| author_facet |
Almeida, Vinicius Cotta de Dupré, Löic Guipouy, Delphine Vasconcelos, Zilton Farias Meira de |
| author_role |
author |
| author2 |
Dupré, Löic Guipouy, Delphine Vasconcelos, Zilton Farias Meira de |
| author2_role |
author author author |
| dc.contributor.author.fl_str_mv |
Almeida, Vinicius Cotta de Dupré, Löic Guipouy, Delphine Vasconcelos, Zilton Farias Meira de |
| dc.subject.other.pt_BR.fl_str_mv |
Transcrição Comunicação |
| topic |
Transcrição Comunicação Wiskott–Aldrich syndrome T lymphocytes Actin cytoskeleton Motility Immunological synapse Signaling Transcription Citoesqueleto de Actina Motilidade Linfócitos T Citoesqueleto de Actina |
| dc.subject.en.pt_BR.fl_str_mv |
Wiskott–Aldrich syndrome T lymphocytes Actin cytoskeleton Motility Immunological synapse Signaling Transcription |
| dc.subject.decs.pt_BR.fl_str_mv |
Citoesqueleto de Actina Motilidade Linfócitos T Citoesqueleto de Actina |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. |
| publishDate |
2015 |
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2015-08-19T13:49:20Z |
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2015-08-19T13:49:20Z |
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2015 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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ALMEIDA, Vinicius Cotta de et al. Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome. Frontiers in Immunology, v. 6, Article 47, p. 1-11, Feb. 2015. |
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https://www.arca.fiocruz.br/handle/icict/11488 |
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1664-3224 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.3389/fimmu.2015.00047 |
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ALMEIDA, Vinicius Cotta de et al. Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome. Frontiers in Immunology, v. 6, Article 47, p. 1-11, Feb. 2015. 1664-3224 10.3389/fimmu.2015.00047 |
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https://www.arca.fiocruz.br/handle/icict/11488 |
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eng |
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openAccess |
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University of Washington |
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University of Washington |
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