Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains

Detalhes bibliográficos
Autor(a) principal: Giovanetti, Marta
Data de Publicação: 2016
Outros Autores: Milano, Teresa, Alcantara, Luiz Carlos Júnior, Carcangiu, Laura, Cella, Eleonora, Lai, Alessia, Lo Presti, Alessandra, Pascarella, Stefano, Zehender, Gianguglielmo, Angeletti, Silvia, Ciccozzi, Massimo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16421
Resumo: National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University of Rome ‘Tor Vergata’. Department of Biology. Rome, Italy / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.
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spelling Giovanetti, MartaMilano, TeresaAlcantara, Luiz Carlos JúniorCarcangiu, LauraCella, EleonoraLai, AlessiaLo Presti, AlessandraPascarella, StefanoZehender, GianguglielmoAngeletti, SilviaCiccozzi, Massimo2016-05-10T18:56:32Z2016-12-02T17:32:29Z2016GIOVANETTI, Marta et al. Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains. Asian Pacific Journal of Tropical Medicine, v. 9, n. 5, p. 445–452, 2016.1995-7645https://www.arca.fiocruz.br/handle/icict/1642110.1016/j.apjtm.2016.03.028engElsevierZika VirusFilogeniaEvoluçãoCirculaçãoZika VirusPhylogenyEvolutionCirculationZika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University of Rome ‘Tor Vergata’. Department of Biology. Rome, Italy / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Universit`a La Sapienza. Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’. Roma, Italy.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.University of Milan. Laboratory of Infectious Diseases and Tropical Medicine. Milan, Italy.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy.Universit`a La Sapienza. Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’. Roma, Italy.University of Milan. Laboratory of Infectious Diseases and Tropical Medicine. Milan, Italy.University Hospital Campus Bio-Medico of Rome. Clinical Pathology and Microbiology Laboratory. Rome, Italy.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University Campus Bio-Medico. Rome, Italy.To investigate the genetic diversity of Zika Virus (ZIKV) and the relationships existing among these circulating viruses worldwide. To evaluate the genetic polymorphisms harbored from ZIKV that can have an influence on the virus circulation. Methods: Three different ZIKV dataset were built. The first dataset included 63 E gene sequences, the second one 22 NS3 sequences and the third dataset was composed of 108 NS5 gene sequences. Phylogenetic and selective pressure analysis was performed. The edited nucleic acid alignment from the Envelope dataset was used to generate a conceptual translation to the corresponding peptide sequences through UGene software. Results: The phylogeographic reconstruction was able to discriminate unambiguously that the Brazilian strains are belonged to the Asian lineage. The structural analysis reveals instead the presence of the Ser residue in the Brazilian sequences (however already observed in other previously reported ZIKV infections) that could suggest the presence of a neutralization-resistant population of viruses. Conclusions: Phylogenetic, evolutionary and selective pressure analysis contributed to improve the knowledge on the circulation of ZIKV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14170/1/license.txt5a560609d32a3863062d77ff32785d58MD51TEXTGiovanetti M Zika Virus spreading in South America - Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains.pdf.txtGiovanetti M Zika Virus spreading in South America - Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
title Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
spellingShingle Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
Giovanetti, Marta
Zika Virus
Filogenia
Evolução
Circulação
Zika Virus
Phylogeny
Evolution
Circulation
title_short Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
title_full Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
title_fullStr Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
title_full_unstemmed Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
title_sort Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
author Giovanetti, Marta
author_facet Giovanetti, Marta
Milano, Teresa
Alcantara, Luiz Carlos Júnior
Carcangiu, Laura
Cella, Eleonora
Lai, Alessia
Lo Presti, Alessandra
Pascarella, Stefano
Zehender, Gianguglielmo
Angeletti, Silvia
Ciccozzi, Massimo
author_role author
author2 Milano, Teresa
Alcantara, Luiz Carlos Júnior
Carcangiu, Laura
Cella, Eleonora
Lai, Alessia
Lo Presti, Alessandra
Pascarella, Stefano
Zehender, Gianguglielmo
Angeletti, Silvia
Ciccozzi, Massimo
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Giovanetti, Marta
Milano, Teresa
Alcantara, Luiz Carlos Júnior
Carcangiu, Laura
Cella, Eleonora
Lai, Alessia
Lo Presti, Alessandra
Pascarella, Stefano
Zehender, Gianguglielmo
Angeletti, Silvia
Ciccozzi, Massimo
dc.subject.other.pt_BR.fl_str_mv Zika Virus
Filogenia
Evolução
Circulação
topic Zika Virus
Filogenia
Evolução
Circulação
Zika Virus
Phylogeny
Evolution
Circulation
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Phylogeny
Evolution
Circulation
description National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University of Rome ‘Tor Vergata’. Department of Biology. Rome, Italy / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-05-10T18:56:32Z
dc.date.available.fl_str_mv 2016-12-02T17:32:29Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GIOVANETTI, Marta et al. Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains. Asian Pacific Journal of Tropical Medicine, v. 9, n. 5, p. 445–452, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16421
dc.identifier.issn.none.fl_str_mv 1995-7645
dc.identifier.doi.none.fl_str_mv 10.1016/j.apjtm.2016.03.028
identifier_str_mv GIOVANETTI, Marta et al. Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains. Asian Pacific Journal of Tropical Medicine, v. 9, n. 5, p. 445–452, 2016.
1995-7645
10.1016/j.apjtm.2016.03.028
url https://www.arca.fiocruz.br/handle/icict/16421
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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