Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16421 |
Resumo: | National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University of Rome ‘Tor Vergata’. Department of Biology. Rome, Italy / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. |
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Giovanetti, MartaMilano, TeresaAlcantara, Luiz Carlos JúniorCarcangiu, LauraCella, EleonoraLai, AlessiaLo Presti, AlessandraPascarella, StefanoZehender, GianguglielmoAngeletti, SilviaCiccozzi, Massimo2016-05-10T18:56:32Z2016-12-02T17:32:29Z2016GIOVANETTI, Marta et al. Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains. Asian Pacific Journal of Tropical Medicine, v. 9, n. 5, p. 445–452, 2016.1995-7645https://www.arca.fiocruz.br/handle/icict/1642110.1016/j.apjtm.2016.03.028engElsevierZika VirusFilogeniaEvoluçãoCirculaçãoZika VirusPhylogenyEvolutionCirculationZika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University of Rome ‘Tor Vergata’. Department of Biology. Rome, Italy / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.Universit`a La Sapienza. Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’. Roma, Italy.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / Sapienza University of Rome. Department of Public Health and Infectious Diseases. Rome, Italy.University of Milan. Laboratory of Infectious Diseases and Tropical Medicine. Milan, Italy.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy.Universit`a La Sapienza. Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’. Roma, Italy.University of Milan. Laboratory of Infectious Diseases and Tropical Medicine. Milan, Italy.University Hospital Campus Bio-Medico of Rome. Clinical Pathology and Microbiology Laboratory. Rome, Italy.National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University Campus Bio-Medico. Rome, Italy.To investigate the genetic diversity of Zika Virus (ZIKV) and the relationships existing among these circulating viruses worldwide. To evaluate the genetic polymorphisms harbored from ZIKV that can have an influence on the virus circulation. Methods: Three different ZIKV dataset were built. The first dataset included 63 E gene sequences, the second one 22 NS3 sequences and the third dataset was composed of 108 NS5 gene sequences. Phylogenetic and selective pressure analysis was performed. The edited nucleic acid alignment from the Envelope dataset was used to generate a conceptual translation to the corresponding peptide sequences through UGene software. Results: The phylogeographic reconstruction was able to discriminate unambiguously that the Brazilian strains are belonged to the Asian lineage. The structural analysis reveals instead the presence of the Ser residue in the Brazilian sequences (however already observed in other previously reported ZIKV infections) that could suggest the presence of a neutralization-resistant population of viruses. Conclusions: Phylogenetic, evolutionary and selective pressure analysis contributed to improve the knowledge on the circulation of ZIKV.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14170/1/license.txt5a560609d32a3863062d77ff32785d58MD51TEXTGiovanetti M Zika Virus spreading in South America - Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains.pdf.txtGiovanetti M Zika Virus spreading in South America - Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains |
title |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains |
spellingShingle |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains Giovanetti, Marta Zika Virus Filogenia Evolução Circulação Zika Virus Phylogeny Evolution Circulation |
title_short |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains |
title_full |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains |
title_fullStr |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains |
title_full_unstemmed |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains |
title_sort |
Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains |
author |
Giovanetti, Marta |
author_facet |
Giovanetti, Marta Milano, Teresa Alcantara, Luiz Carlos Júnior Carcangiu, Laura Cella, Eleonora Lai, Alessia Lo Presti, Alessandra Pascarella, Stefano Zehender, Gianguglielmo Angeletti, Silvia Ciccozzi, Massimo |
author_role |
author |
author2 |
Milano, Teresa Alcantara, Luiz Carlos Júnior Carcangiu, Laura Cella, Eleonora Lai, Alessia Lo Presti, Alessandra Pascarella, Stefano Zehender, Gianguglielmo Angeletti, Silvia Ciccozzi, Massimo |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Giovanetti, Marta Milano, Teresa Alcantara, Luiz Carlos Júnior Carcangiu, Laura Cella, Eleonora Lai, Alessia Lo Presti, Alessandra Pascarella, Stefano Zehender, Gianguglielmo Angeletti, Silvia Ciccozzi, Massimo |
dc.subject.other.pt_BR.fl_str_mv |
Zika Virus Filogenia Evolução Circulação |
topic |
Zika Virus Filogenia Evolução Circulação Zika Virus Phylogeny Evolution Circulation |
dc.subject.en.pt_BR.fl_str_mv |
Zika Virus Phylogeny Evolution Circulation |
description |
National Institute of Health. Department of Infectious Parasitic and Immunomediated Diseases. Rome, Italy / University of Rome ‘Tor Vergata’. Department of Biology. Rome, Italy / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, Brasil. |
publishDate |
2016 |
dc.date.accessioned.fl_str_mv |
2016-05-10T18:56:32Z |
dc.date.available.fl_str_mv |
2016-12-02T17:32:29Z |
dc.date.issued.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GIOVANETTI, Marta et al. Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains. Asian Pacific Journal of Tropical Medicine, v. 9, n. 5, p. 445–452, 2016. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/16421 |
dc.identifier.issn.none.fl_str_mv |
1995-7645 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.apjtm.2016.03.028 |
identifier_str_mv |
GIOVANETTI, Marta et al. Zika Virus spreading in South America: Evolutionary analysis of emerging neutralizing resistant Phe279Ser strains. Asian Pacific Journal of Tropical Medicine, v. 9, n. 5, p. 445–452, 2016. 1995-7645 10.1016/j.apjtm.2016.03.028 |
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https://www.arca.fiocruz.br/handle/icict/16421 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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Elsevier |
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Elsevier |
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