Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.actatropica.2015.08.013 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/21079 |
Resumo: | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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Rocha, Hélio Daniel RibeiroPaiva, Marcelo Henrique SantosSilva, Norma Machadode Araújo, Ana PaulaCamacho, Denise dos Reis da Rosa de AzevedoMoura, Aires Januário Fernandes daGómez, Lara FerreroAyres, Constância Flávia JunqueiraSantos, Maria Alice Varjal de Melo2017-09-21T12:52:03Z2017-09-21T12:52:03Z2015ROCHA, H. D. R. et al. Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides. Acta Tropica, v. 152, p. 66–73, dez. 2015.1873-6254https://www.arca.fiocruz.br/handle/icict/2107910.1016/j.actatropica.2015.08.013porAedesDengueResistência a InseticidasInseticidasAedesdrug effectsAnimalsCape VerdeepidemiologyDengueprevention & controlDisease VectorsFemaleInsecticide ResistanceInsecticidesLarvaLethal Dose 50Mosquito ControlAedesDengueResistência a InseticidasInseticidasefeitos de drogasCabo VerdeepidemiologiaAnimaisFemininoDose Letal MedianaControle de MosquitosmétodosVetores de Doençasprevenção & controleSusceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticidesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, BrasilIn 2009, Cabo Verde diagnosed the first dengue cases, with 21,137 cases reported and Aedes aegypti was identified as the vector. Since the outbreak, chemical insecticides and source reduction were used to control the mosquito population. This study aimed to assess the susceptibility of A. aegypti populations from Santiago, Cabo Verde to insecticides and identify the mechanisms of resistance. Samples of A. aegypti eggs were obtained at two different time periods (2012 and 2014), using ovitraps in different locations in Santiago Island to establish the parental population. F1 larvae were exposed to different concentrations of insecticides (Bacillus thuringiensis var israelensis (Bti), diflubenzuron and temephos) to estimate the lethal concentrations (LC90) and calculate the respective rate of resistance (RR90). Semi-field tests using temephos-ABATE(®) were performed to evaluate the persistence of the product. Bottle tests using female mosquitoes were carried out to determine the susceptibility to the adulticides malathion, cypermethrin and deltamethrin. Biochemical and molecular tests were performed to investigate the presence of metabolic resistance mechanisms, associated with the enzymes glutathione S-transferases (GSTs), esterases and mixed-function oxidases (MFO) and to detect mutations or alterations in the sodium channel and acetylcholinesterase genes. A. aegypti mosquitoes from Santiago exhibited resistance to deltamethrin, cypermethrin (mortality<80%) and temephos (RR90=4.4) but susceptibility to malathion (mortality≥98%), Bti and diflubenzuron. The low level of resistance to temephos did not affect the effectiveness of Abate(®). The enzymatic analysis conducted in 2012 revealed slight changes in the activities of GST (25%), MFO (18%), α-esterase (19%) and β-esterase (17%), but no significant changes in 2014. Target site resistance mutations were not detected. Our results suggest that the A. aegypti population from Santiago is resistant to two major insecticides used for vector control, deltamethrin and temephos. To our knowledge, this is the first report of temephos resistance in an African A. aegypti population. The low level of temephos resistance was maintained from 2012-2014, which suggested the imposition of selective pressure, although it was not possible to identify the resistance mechanisms involved. These data show that the potential failures in the local mosquito control program are not associated with insecticide resistance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/21079/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL26307496 2015 roc-sus.oa.wo.pdf.ed.pdf26307496 2015 roc-sus.oa.wo.pdf.ed.pdfapplication/pdf857693https://www.arca.fiocruz.br/bitstream/icict/21079/2/26307496%202015%20roc-sus.oa.wo.pdf.ed.pdf88721db53d43c2d2f2e41e119ad1315aMD52TEXT26307496 2015 roc-sus.oa.wo.pdf.ed.pdf.txt26307496 2015 roc-sus.oa.wo.pdf.ed.pdf.txtExtracted texttext/plain51368https://www.arca.fiocruz.br/bitstream/icict/21079/3/26307496%202015%20roc-sus.oa.wo.pdf.ed.pdf.txt7a7d7ade2dba5edfef08fcadbf3b8e7eMD53icict/210792018-08-15 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| dc.title.pt_BR.fl_str_mv |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides |
| title |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides |
| spellingShingle |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides Rocha, Hélio Daniel Ribeiro Aedes Dengue Resistência a Inseticidas Inseticidas Aedes drug effects Animals Cape Verde epidemiology Dengue prevention & control Disease Vectors Female Insecticide Resistance Insecticides Larva Lethal Dose 50 Mosquito Control Aedes Dengue Resistência a Inseticidas Inseticidas efeitos de drogas Cabo Verde epidemiologia Animais Feminino Dose Letal Mediana Controle de Mosquitos métodos Vetores de Doenças prevenção & controle |
| title_short |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides |
| title_full |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides |
| title_fullStr |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides |
| title_full_unstemmed |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides |
| title_sort |
Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides |
| author |
Rocha, Hélio Daniel Ribeiro |
| author_facet |
Rocha, Hélio Daniel Ribeiro Paiva, Marcelo Henrique Santos Silva, Norma Machado de Araújo, Ana Paula Camacho, Denise dos Reis da Rosa de Azevedo Moura, Aires Januário Fernandes da Gómez, Lara Ferrero Ayres, Constância Flávia Junqueira Santos, Maria Alice Varjal de Melo |
| author_role |
author |
| author2 |
Paiva, Marcelo Henrique Santos Silva, Norma Machado de Araújo, Ana Paula Camacho, Denise dos Reis da Rosa de Azevedo Moura, Aires Januário Fernandes da Gómez, Lara Ferrero Ayres, Constância Flávia Junqueira Santos, Maria Alice Varjal de Melo |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rocha, Hélio Daniel Ribeiro Paiva, Marcelo Henrique Santos Silva, Norma Machado de Araújo, Ana Paula Camacho, Denise dos Reis da Rosa de Azevedo Moura, Aires Januário Fernandes da Gómez, Lara Ferrero Ayres, Constância Flávia Junqueira Santos, Maria Alice Varjal de Melo |
| dc.subject.other.pt_BR.fl_str_mv |
Aedes Dengue Resistência a Inseticidas Inseticidas |
| topic |
Aedes Dengue Resistência a Inseticidas Inseticidas Aedes drug effects Animals Cape Verde epidemiology Dengue prevention & control Disease Vectors Female Insecticide Resistance Insecticides Larva Lethal Dose 50 Mosquito Control Aedes Dengue Resistência a Inseticidas Inseticidas efeitos de drogas Cabo Verde epidemiologia Animais Feminino Dose Letal Mediana Controle de Mosquitos métodos Vetores de Doenças prevenção & controle |
| dc.subject.en.pt_BR.fl_str_mv |
Aedes drug effects Animals Cape Verde epidemiology Dengue prevention & control Disease Vectors Female Insecticide Resistance Insecticides Larva Lethal Dose 50 Mosquito Control |
| dc.subject.decs.pt_BR.fl_str_mv |
Aedes Dengue Resistência a Inseticidas Inseticidas efeitos de drogas Cabo Verde epidemiologia Animais Feminino Dose Letal Mediana Controle de Mosquitos métodos Vetores de Doenças prevenção & controle |
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Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil |
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2015 |
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2015 |
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ROCHA, H. D. R. et al. Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides. Acta Tropica, v. 152, p. 66–73, dez. 2015. |
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1873-6254 |
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10.1016/j.actatropica.2015.08.013 |
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ROCHA, H. D. R. et al. Susceptibility profile of Aedes aegypti from Santiago Island, Cabo Verde, to insecticides. Acta Tropica, v. 152, p. 66–73, dez. 2015. 1873-6254 10.1016/j.actatropica.2015.08.013 |
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