CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45994 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
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Santos, Alessandro Marins dosOlivieri, Bianca PerdigãoReis, Rafaella FerreiraMeis, Juliana deSilva, Andrea AliceAraujo-Jorge, Tania C. deVieira, Joseli LannesAlmeida, Vinicius Cotta de2021-02-08T19:22:23Z2021-02-08T19:22:23Z2020SANTOS, Alessandro Marins dos et al. CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers. Plos Negl Trop Dis., v. 14, n. 12, e0008969, 15p, Dec. 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4599410.1371/journal. pntd.0008969engPublic Library of ScienceCélulas CD8low TInfecção por trypanosoma cruziTratamento de benznidazolProdutores de γ IFNCD8low T cellsTrypanosoma cruzi infectionBenznidazole TreatmentIFN-γ producersCD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Escola de Medicina. Departamento de Patologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.CD8 T cells are regarded as pivotal players in both immunoprotection and immunopathology following Trypanosoma cruzi infection. Previously, we demonstrated the expansion of CD8+ T lymphocytes in the spleen of T. cruzi-infected mice under treatment with benznidazole (Nbenzyl- 2-nitroimidazole acetamide; Bz), a drug available for clinical therapy. This finding underlies the concept that the beneficial effects of Bz on controlling acute T. cruzi infection are related to a synergistic process between intrinsic trypanocidal effect and indirect triggering of the active immune response. In the present study, we particularly investigated the effect of Bz treatment on the CD8+ T cell subset following T. cruzi infection. Herein we demonstrated that, during acute T. cruzi infection, Bz treatment reduces and abbreviates the parasitemia, but maintains elevated expansion of CD8+ T cells. Within this subset, a remarkable group of CD8low cells was found in both Bz-treated and non-treated infected mice. In Bz-treated mice, early pathogen control paralleled the lower frequency of recently activated CD8low cells, as ascertained by CD69 expression. However, the CD8low subset sustains significant levels of CD44highCD62Llow and CD62LlowT-bethigh effector memory T cells, in both Bz-treated and non-treated infected mice. These CD8low cells also comprise the main group of spontaneous interferon (IFN)-γ-producing CD8+ T cells. Interestingly, following in vitro anti-CD3/CD28 stimulation, CD8+ T cells from Bz-treated T. cruzi-infected mice exhibited higher frequency of IFN-γ+ cells, which bear mostly a CD8low phenotype. Altogether, our results point to the marked presence of CD8low T cells that arise during acute T. cruzi infection, with Bz treatment promoting their significant expansion along with a potential effector program for high IFN-γ production.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45994/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALAlessandoSantos_ViniciusCAlmeida_etal_IOC_2020.pdfAlessandoSantos_ViniciusCAlmeida_etal_IOC_2020.pdfapplication/pdf1954626https://www.arca.fiocruz.br/bitstream/icict/45994/2/AlessandoSantos_ViniciusCAlmeida_etal_IOC_2020.pdf1cce452aeb7ee10766500d30906f02adMD52TEXTAlessandoSantos_ViniciusCAlmeida_etal_IOC_2020.pdf.txtAlessandoSantos_ViniciusCAlmeida_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers |
title |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers |
spellingShingle |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers Santos, Alessandro Marins dos Células CD8low T Infecção por trypanosoma cruzi Tratamento de benznidazol Produtores de γ IFN CD8low T cells Trypanosoma cruzi infection Benznidazole Treatment IFN-γ producers |
title_short |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers |
title_full |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers |
title_fullStr |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers |
title_full_unstemmed |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers |
title_sort |
CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers |
author |
Santos, Alessandro Marins dos |
author_facet |
Santos, Alessandro Marins dos Olivieri, Bianca Perdigão Reis, Rafaella Ferreira Meis, Juliana de Silva, Andrea Alice Araujo-Jorge, Tania C. de Vieira, Joseli Lannes Almeida, Vinicius Cotta de |
author_role |
author |
author2 |
Olivieri, Bianca Perdigão Reis, Rafaella Ferreira Meis, Juliana de Silva, Andrea Alice Araujo-Jorge, Tania C. de Vieira, Joseli Lannes Almeida, Vinicius Cotta de |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Alessandro Marins dos Olivieri, Bianca Perdigão Reis, Rafaella Ferreira Meis, Juliana de Silva, Andrea Alice Araujo-Jorge, Tania C. de Vieira, Joseli Lannes Almeida, Vinicius Cotta de |
dc.subject.other.pt_BR.fl_str_mv |
Células CD8low T Infecção por trypanosoma cruzi Tratamento de benznidazol Produtores de γ IFN |
topic |
Células CD8low T Infecção por trypanosoma cruzi Tratamento de benznidazol Produtores de γ IFN CD8low T cells Trypanosoma cruzi infection Benznidazole Treatment IFN-γ producers |
dc.subject.en.pt_BR.fl_str_mv |
CD8low T cells Trypanosoma cruzi infection Benznidazole Treatment IFN-γ producers |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020 |
dc.date.accessioned.fl_str_mv |
2021-02-08T19:22:23Z |
dc.date.available.fl_str_mv |
2021-02-08T19:22:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SANTOS, Alessandro Marins dos et al. CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers. Plos Negl Trop Dis., v. 14, n. 12, e0008969, 15p, Dec. 2020. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/45994 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal. pntd.0008969 |
identifier_str_mv |
SANTOS, Alessandro Marins dos et al. CD8low T cells expanded following acute Trypanosoma cruzi infection and benznidazole treatment are a relevant subset of IFN-γ producers. Plos Negl Trop Dis., v. 14, n. 12, e0008969, 15p, Dec. 2020. 1935-2727 10.1371/journal. pntd.0008969 |
url |
https://www.arca.fiocruz.br/handle/icict/45994 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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