The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response

Detalhes bibliográficos
Autor(a) principal: Costa, Fernanda Silva da
Data de Publicação: 2020
Outros Autores: Rodrigues, Vanessa Fernandes, Rezende, Michelle Carvalho de, Oliveira, Jailza Lima Rodrigues, Coelho, Paulo Marcos Zech, Corrêa, Deborah Negrão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58488
Resumo: Department of Parasitology. Biological Science Institute. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil / Oswaldo Cruz Foundation. René Rachou Institute. Laboratory of Schistosomiasis. Belo Horizonte, MG, Brazil.
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spelling Costa, Fernanda Silva daRodrigues, Vanessa FernandesRezende, Michelle Carvalho deOliveira, Jailza Lima RodriguesCoelho, Paulo Marcos ZechCorrêa, Deborah Negrão2023-05-18T19:29:42Z2023-05-18T19:29:42Z2020COSTA, Fernanda Silva da et al. The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response. Veterinary Parasitology, v. 278, p. 1-8, 109037, 2020.0304-4017https://www.arca.fiocruz.br/handle/icict/5848810.1016/j.vetpar.2020.109037engElsevierThe effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune responseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleDepartment of Parasitology. Biological Science Institute. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil / Oswaldo Cruz Foundation. René Rachou Institute. Laboratory of Schistosomiasis. Belo Horizonte, MG, Brazil.Federal University of Minas Gerais. Biological Science Institute. Department of Parasitology. Belo Horizonte, MG, Brazil.Federal University of Minas Gerais. Biological Science Institute. Department of Parasitology. Belo Horizonte, MG, Brazil.Federal University of Minas Gerais. Biological Science Institute. Department of Parasitology. Belo Horizonte, MG, Brazil.Oswaldo Cruz Foundation. René Rachou Institute. Laboratory of Schistosomiasis. Belo Horizonte, MG, Brazil.Federal University of Minas Gerais. Biological Science Institute. Department of Parasitology. Belo Horizonte, MG, Brazil.Species of Strongyloides infect a wide range of hosts worldwide. Due to their complex life cycle, it is hard to control the transmission of these parasites. Several species show evidence of vertical transmission; however, the impact of this transmission route on the susceptibility of the offspring has been poorly investigated. Herein, we used Strongyloides venezuelensis infected mice to evaluate transplacental and transmammary parasite transmission and their effect on the susceptibility of offspring. Swiss female mice were infected at the end of the gestation or during the breastfeeding period, and their offspring were examined for the presence of the parasite one week after infection of the mother. Our data showed that female mice infected with S. venezuelensis during gestation did not transmit the parasite to their offspring. On the other hand, all newborn mice breastfeeding in S. venezuelensis infected females got infected. To evaluate the effect of early exposure to the parasite on susceptibility and immune response of the hosts, the offspring of each experimental group (non-infected, gestation-infected, and breastfeeding-infected mothers) received anti-helminth treatment after parasite evaluation and were subcutaneously infected with S. venezuelensis upon reaching adulthood. Mice from the group of breastfeeding-infected mothers showed lower susceptibility to S. venezuelensis in adulthood in comparison with mice from non infected mothers. The low parasite burden was accompanied by earlier eosinophil and neutrophil activation in the gut and higher serum levels of IgE. In contrast, S. venezuelensis infection in adult mice born from gestation-infected mothers presented with more worms in the intestine and lower levels of parasite-reactive IgM in serum in comparison with mice born from non-infected mothers, thus suggesting that early exposure to parasite antigens may modulate the protective immune response. Altogether, our data confirmed transmammary, but not transplacental, transmission of S. venezuelensis in mice and demonstrated that early exposure to the parasite and/or their antigens has an important effect on host susceptibility to a later infection.Protective immunityStrongyloides venezuelensisTransmammary transmission in miceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALThe effect of maternal Strongyloides venezuelensis.pdfThe effect of maternal Strongyloides venezuelensis.pdfapplication/pdf5351071https://www.arca.fiocruz.br/bitstream/icict/58488/2/The%20effect%20of%20maternal%20Strongyloides%20venezuelensis.pdfd31442bcdbb74cb39e376110f0047b95MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/58488/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/584882023-05-18 23:08:59.213oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-05-19T02:08:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
title The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
spellingShingle The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
Costa, Fernanda Silva da
Protective immunity
Strongyloides venezuelensis
Transmammary transmission in mice
title_short The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
title_full The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
title_fullStr The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
title_full_unstemmed The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
title_sort The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response
author Costa, Fernanda Silva da
author_facet Costa, Fernanda Silva da
Rodrigues, Vanessa Fernandes
Rezende, Michelle Carvalho de
Oliveira, Jailza Lima Rodrigues
Coelho, Paulo Marcos Zech
Corrêa, Deborah Negrão
author_role author
author2 Rodrigues, Vanessa Fernandes
Rezende, Michelle Carvalho de
Oliveira, Jailza Lima Rodrigues
Coelho, Paulo Marcos Zech
Corrêa, Deborah Negrão
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Fernanda Silva da
Rodrigues, Vanessa Fernandes
Rezende, Michelle Carvalho de
Oliveira, Jailza Lima Rodrigues
Coelho, Paulo Marcos Zech
Corrêa, Deborah Negrão
dc.subject.en.en_US.fl_str_mv Protective immunity
Strongyloides venezuelensis
Transmammary transmission in mice
topic Protective immunity
Strongyloides venezuelensis
Transmammary transmission in mice
description Department of Parasitology. Biological Science Institute. Federal University of Minas Gerais. Belo Horizonte, MG, Brazil / Oswaldo Cruz Foundation. René Rachou Institute. Laboratory of Schistosomiasis. Belo Horizonte, MG, Brazil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2023-05-18T19:29:42Z
dc.date.available.fl_str_mv 2023-05-18T19:29:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COSTA, Fernanda Silva da et al. The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response. Veterinary Parasitology, v. 278, p. 1-8, 109037, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58488
dc.identifier.issn.en_US.fl_str_mv 0304-4017
dc.identifier.doi.none.fl_str_mv 10.1016/j.vetpar.2020.109037
identifier_str_mv COSTA, Fernanda Silva da et al. The effect of maternal Strongyloides venezuelensis infection on mice offspring susceptibility and immune response. Veterinary Parasitology, v. 278, p. 1-8, 109037, 2020.
0304-4017
10.1016/j.vetpar.2020.109037
url https://www.arca.fiocruz.br/handle/icict/58488
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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collection Repositório Institucional da FIOCRUZ (ARCA)
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