Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions

Detalhes bibliográficos
Autor(a) principal: Pérez, Ana Rosa
Data de Publicação: 2018
Outros Autores: Morrot, Alexandre, Carvalho, Vinicius Frias, Meis, Juliana de, Savino, Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/29453
Resumo: Institute of Clinical and Experimental Immunology. Rosario, Argentina.
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spelling Pérez, Ana RosaMorrot, AlexandreCarvalho, Vinicius FriasMeis, Juliana deSavino, Wilson2018-10-09T12:56:16Z2018-10-09T12:56:16Z2018PÈREZ, Ana Rosa; et al. Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions. Frontiers in Endocrinology, v.9, Article 334, 8p, June 2018.1664-2392https://www.arca.fiocruz.br/handle/icict/2945310.3389/fendo.2018.00334engFrontiers Mediaatrofia do timoprolactinaDoença de Chagashormonio de crescimentotimócitoseixo hipotálamo-hipófise-adrenalChagas diseasethymus atrophythymocyteshypothalamus–pituitary–adrenal axisgrowth hormoneprolactinRole of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInstitute of Clinical and Experimental Immunology. Rosario, Argentina.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Centro de Pesquisas em Tuberculose. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.T cell response plays an essential role in the host resistance to infection by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. This infection is often associated with multiple manifestations of T cell dysfunction, both during the acute and the chronic phases of disease. Additionally, the normal development of T cells is affected. As seen in animal models of Chagas disease, there is a strong thymic atrophy due to massive death of CD4+CD8+ double-positive cells by apoptosis and an abnormal escape of immature and potentially autoreactive thymocytes from the organ. Furthermore, an increase in the release of corticosterone triggered by T. cruzi-driven systemic inflammation is strongly associated with the alterations seen in the thymus of infected animals. Moreover, changes in the levels of other hormones, including growth hormone, prolactin, and testosterone are also able to contribute to the disruption of thymic homeostasis secondary to T. cruzi infection. In this review, we discuss the role of hormonal circuits involved in the normal T cell development and trafficking, as well as their role on the thymic alterations likely related to the peripheral T cell disturbances largely reported in both chagasic patients and animal models of Chagas disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/29453/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALalexandre_Morrot_etal_IOC_2018.pdfalexandre_Morrot_etal_IOC_2018.pdfapplication/pdf414698https://www.arca.fiocruz.br/bitstream/icict/29453/2/alexandre_Morrot_etal_IOC_2018.pdf4a7b03fa9eed4564722701df4f6c87c1MD52TEXTalexandre_Morrot_etal_IOC_2018.pdf.txtalexandre_Morrot_etal_IOC_2018.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
title Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
spellingShingle Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
Pérez, Ana Rosa
atrofia do timo
prolactina
Doença de Chagas
hormonio de crescimento
timócitos
eixo hipotálamo-hipófise-adrenal
Chagas disease
thymus atrophy
thymocytes
hypothalamus–pituitary–adrenal axis
growth hormone
prolactin
title_short Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
title_full Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
title_fullStr Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
title_full_unstemmed Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
title_sort Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions
author Pérez, Ana Rosa
author_facet Pérez, Ana Rosa
Morrot, Alexandre
Carvalho, Vinicius Frias
Meis, Juliana de
Savino, Wilson
author_role author
author2 Morrot, Alexandre
Carvalho, Vinicius Frias
Meis, Juliana de
Savino, Wilson
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pérez, Ana Rosa
Morrot, Alexandre
Carvalho, Vinicius Frias
Meis, Juliana de
Savino, Wilson
dc.subject.other.pt_BR.fl_str_mv atrofia do timo
prolactina
Doença de Chagas
hormonio de crescimento
timócitos
eixo hipotálamo-hipófise-adrenal
topic atrofia do timo
prolactina
Doença de Chagas
hormonio de crescimento
timócitos
eixo hipotálamo-hipófise-adrenal
Chagas disease
thymus atrophy
thymocytes
hypothalamus–pituitary–adrenal axis
growth hormone
prolactin
dc.subject.en.pt_BR.fl_str_mv Chagas disease
thymus atrophy
thymocytes
hypothalamus–pituitary–adrenal axis
growth hormone
prolactin
description Institute of Clinical and Experimental Immunology. Rosario, Argentina.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-10-09T12:56:16Z
dc.date.available.fl_str_mv 2018-10-09T12:56:16Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PÈREZ, Ana Rosa; et al. Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions. Frontiers in Endocrinology, v.9, Article 334, 8p, June 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/29453
dc.identifier.issn.pt_BR.fl_str_mv 1664-2392
dc.identifier.doi.none.fl_str_mv 10.3389/fendo.2018.00334
identifier_str_mv PÈREZ, Ana Rosa; et al. Role of Hormonal Circuitry Upon T Cell Development in Chagas Disease: Possible Implications on T Cell Dysfunctions. Frontiers in Endocrinology, v.9, Article 334, 8p, June 2018.
1664-2392
10.3389/fendo.2018.00334
url https://www.arca.fiocruz.br/handle/icict/29453
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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