Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.

Detalhes bibliográficos
Autor(a) principal: Tibúrcio, Rafael
Data de Publicação: 2019
Outros Autores: Nunes, Sara, Nunes, Ivanéia, Ampuero, Mariana Rosa, Silva, Icaro Bonyek, Lima, Reinan, Tavares, Natalia Machado, Brodskyn, Cláudia Ida
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32118
Resumo: CNPq, CAPES, and Fapesb.
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spelling Tibúrcio, RafaelNunes, SaraNunes, IvanéiaAmpuero, Mariana RosaSilva, Icaro BonyekLima, ReinanTavares, Natalia MachadoBrodskyn, Cláudia Ida2019-03-15T17:12:55Z2019-03-15T17:12:55Z2019RAFAEL, T. et al. Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View. Frontiers In Immunology, v. 10, p. 227, fev. 2019.1664-3224https://www.arca.fiocruz.br/handle/icict/32118CNPq, CAPES, and Fapesb.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil.Dendritic cells (DC) are a diverse group of leukocytes responsible for bridging innate and adaptive immunity. Despite their functional versatility, DCs exist primarily in two basic functional states: immature and mature. A large body of evidence suggests that upon interactions with pathogens, DCs undergo intricate cellular processes that culminate in their activation, which is paramount to the orchestration of effective immune responses against Leishmania parasites. Herein we offer a concise review of the emerging hallmarks of DCs activation in leishmaniasis as well as a comprehensive discussion of the following underlying molecular events: DC-Leishmania interaction, antigen uptake, costimulatory molecule expression, parasite ability to affect DC migration, antigen presentation, metabolic reprogramming, and epigenetic alterations.engFrontiers MediaAtivação de células dendríticasInteração de células leishmania-dendríticasCaptação de parasitasMigração de células dendríticasMetabolismo de infecçãoModificações epigenéticasDendritic cell activationLeishmania- dendritic cell interactionParasite uptakeDendritic cells migrationMetabolism of infectionEpigenetic modificationsMolecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32118/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALTibúrcio R. Molecular Aspects of Dendritic...2019.pdfTibúrcio R. Molecular Aspects of Dendritic...2019.pdfapplication/pdf1180766https://www.arca.fiocruz.br/bitstream/icict/32118/2/Tib%c3%barcio%20R.%20Molecular%20Aspects%20of%20Dendritic...2019.pdf9b4d767e1eda6707a55d9a0127bbf906MD52TEXTTibúrcio R. Molecular Aspects of Dendritic...2019.pdf.txtTibúrcio R. 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dc.title.pt_BR.fl_str_mv Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
title Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
spellingShingle Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
Tibúrcio, Rafael
Ativação de células dendríticas
Interação de células leishmania-dendríticas
Captação de parasitas
Migração de células dendríticas
Metabolismo de infecção
Modificações epigenéticas
Dendritic cell activation
Leishmania- dendritic cell interaction
Parasite uptake
Dendritic cells migration
Metabolism of infection
Epigenetic modifications
title_short Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
title_full Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
title_fullStr Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
title_full_unstemmed Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
title_sort Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View.
author Tibúrcio, Rafael
author_facet Tibúrcio, Rafael
Nunes, Sara
Nunes, Ivanéia
Ampuero, Mariana Rosa
Silva, Icaro Bonyek
Lima, Reinan
Tavares, Natalia Machado
Brodskyn, Cláudia Ida
author_role author
author2 Nunes, Sara
Nunes, Ivanéia
Ampuero, Mariana Rosa
Silva, Icaro Bonyek
Lima, Reinan
Tavares, Natalia Machado
Brodskyn, Cláudia Ida
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tibúrcio, Rafael
Nunes, Sara
Nunes, Ivanéia
Ampuero, Mariana Rosa
Silva, Icaro Bonyek
Lima, Reinan
Tavares, Natalia Machado
Brodskyn, Cláudia Ida
dc.subject.other.pt_BR.fl_str_mv Ativação de células dendríticas
Interação de células leishmania-dendríticas
Captação de parasitas
Migração de células dendríticas
Metabolismo de infecção
Modificações epigenéticas
topic Ativação de células dendríticas
Interação de células leishmania-dendríticas
Captação de parasitas
Migração de células dendríticas
Metabolismo de infecção
Modificações epigenéticas
Dendritic cell activation
Leishmania- dendritic cell interaction
Parasite uptake
Dendritic cells migration
Metabolism of infection
Epigenetic modifications
dc.subject.en.pt_BR.fl_str_mv Dendritic cell activation
Leishmania- dendritic cell interaction
Parasite uptake
Dendritic cells migration
Metabolism of infection
Epigenetic modifications
description CNPq, CAPES, and Fapesb.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-03-15T17:12:55Z
dc.date.available.fl_str_mv 2019-03-15T17:12:55Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RAFAEL, T. et al. Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View. Frontiers In Immunology, v. 10, p. 227, fev. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32118
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
identifier_str_mv RAFAEL, T. et al. Molecular Aspects of Dendritic Cell Activation in Leishmaniasis: An Immunobiological View. Frontiers In Immunology, v. 10, p. 227, fev. 2019.
1664-3224
url https://www.arca.fiocruz.br/handle/icict/32118
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/32118/1/license.txt
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