Effect of Arrabidaea chica extracts on the ehrlich solid tumor development

Detalhes bibliográficos
Autor(a) principal: Machado, Ana Flávia Ribeiro
Data de Publicação: 2012
Outros Autores: Telles, Thalita C., Ferraz, Vany Perpétua, Fagundes, Elaine Maria de Souza, Cassali, Geovanni Dantas, Carvalho, Andréa Teixeira de, Melo, Marilia Martins
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7840
Resumo: Universidade Estadual de Santa Cruz. Departamento de Ciências Agrárias e Ambientais. Ilheús, BA, Brazil
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spelling Machado, Ana Flávia RibeiroTelles, Thalita C.Ferraz, Vany PerpétuaFagundes, Elaine Maria de SouzaCassali, Geovanni DantasCarvalho, Andréa Teixeira deMelo, Marilia Martins2014-06-26T12:18:23Z2014-06-26T12:18:23Z2012RIBEIRO, Ana Flávia Ribeiro et al. Effect of Arrabidaea chica extracts on the ehrlich solid tumor development. Revista Brasileira Farmacognosia. 2012, vol.22, n.2, pp. 364-373 102-695X0102-695Xhttps://www.arca.fiocruz.br/handle/icict/784010.1590/S0102-695X2011005000225engUniversidade Federal do ParanáEffect of Arrabidaea chica extracts on the ehrlich solid tumor developmentinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Santa Cruz. Departamento de Ciências Agrárias e Ambientais. Ilheús, BA, BrazilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Química. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Fisiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia. Belo Horizonte, MG, BrazilThe aim of this study was to investigate the effect of Arrabidaea chica (Humb. & Bonpl.) B. Verl., Bignoniaceae, extracts on Ehrlich solid tumor development in Swiss mice. Leaves of A. chica were extracted with two distinct solvents, ethanol and water. The phytochemical analysis of the extracts indicated different classes of secondary metabolites like as anthocyanidins, flavonoids, tannins and saponins. Ethanol (EE) and aqueous (AE) extracts at 30 mg/kg reduced the development of Ehrlich solid tumor after ten days of oral treatment. The EE group presented increase in neutrophil count, α1 and β globulin values, and decrease of α2 globulin values. Furthermore, EE reduced the percentage of CD4+ T cells in blood but did not alter the percentage of inflammatory mononuclear cells associated with tumor suggesting a direct action of EE on tumor cells. Reduced tumor development observed in AE group was accompanied by a lower percentage of CD4+ T lymphocytes in blood. At the tumor microenvironment, this treatment decreased the percentage of CD3+ T cells, especially due to a reduction of CD8+ T subpopulation and NK cells. The antitumor activity presented by the AE is possibly related to an anti-inflammatory activity. None of the extracts produced toxic effects in animals. In conclusion, the ethanol and aqueous extracts of A. chica have immunomodulatory and antitumor activities attributed to the presence of flavonoids, such as kaempferol. These effects appear to be related to different mechanisms of action for each extract. This study demonstrates the potential of A. chica as an antitumor agent confirming its use in traditional popular medicine.Arrabidaea chicaBignoniaceae, flavonolsEhrlich tumorantitumor activityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALEffect of Arrabidaea chica extracts on the ehrlich solid tumor development.pdfEffect of Arrabidaea chica extracts on the ehrlich solid tumor development.pdfapplication/pdf501014https://www.arca.fiocruz.br/bitstream/icict/7840/1/Effect%20of%20Arrabidaea%20chica%20extracts%20on%20the%20ehrlich%20solid%20tumor%20development.pdfea9ca6085ced480ad7d6c853b923ede3MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7840/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTEffect of Arrabidaea chica extracts on the ehrlich solid tumor development.pdf.txtEffect of Arrabidaea chica extracts on the ehrlich solid tumor development.pdf.txtExtracted texttext/plain44642https://www.arca.fiocruz.br/bitstream/icict/7840/5/Effect%20of%20Arrabidaea%20chica%20extracts%20on%20the%20ehrlich%20solid%20tumor%20development.pdf.txt7db873d637d92d2a7957215b311f80daMD55THUMBNAILEffect of Arrabidaea chica extracts on the ehrlich solid tumor development.pdf.jpgEffect of Arrabidaea chica extracts on the ehrlich solid tumor development.pdf.jpgGenerated Thumbnailimage/jpeg1976https://www.arca.fiocruz.br/bitstream/icict/7840/4/Effect%20of%20Arrabidaea%20chica%20extracts%20on%20the%20ehrlich%20solid%20tumor%20development.pdf.jpg594505b1a4ed5c458885e342e2aff2f0MD54icict/78402018-04-06 11:25:52.231oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T14:25:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
title Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
spellingShingle Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
Machado, Ana Flávia Ribeiro
Arrabidaea chica
Bignoniaceae, flavonols
Ehrlich tumor
antitumor activity
title_short Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
title_full Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
title_fullStr Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
title_full_unstemmed Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
title_sort Effect of Arrabidaea chica extracts on the ehrlich solid tumor development
author Machado, Ana Flávia Ribeiro
author_facet Machado, Ana Flávia Ribeiro
Telles, Thalita C.
Ferraz, Vany Perpétua
Fagundes, Elaine Maria de Souza
Cassali, Geovanni Dantas
Carvalho, Andréa Teixeira de
Melo, Marilia Martins
author_role author
author2 Telles, Thalita C.
Ferraz, Vany Perpétua
Fagundes, Elaine Maria de Souza
Cassali, Geovanni Dantas
Carvalho, Andréa Teixeira de
Melo, Marilia Martins
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Machado, Ana Flávia Ribeiro
Telles, Thalita C.
Ferraz, Vany Perpétua
Fagundes, Elaine Maria de Souza
Cassali, Geovanni Dantas
Carvalho, Andréa Teixeira de
Melo, Marilia Martins
dc.subject.en.pt_BR.fl_str_mv Arrabidaea chica
Bignoniaceae, flavonols
Ehrlich tumor
antitumor activity
topic Arrabidaea chica
Bignoniaceae, flavonols
Ehrlich tumor
antitumor activity
description Universidade Estadual de Santa Cruz. Departamento de Ciências Agrárias e Ambientais. Ilheús, BA, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-06-26T12:18:23Z
dc.date.available.fl_str_mv 2014-06-26T12:18:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv RIBEIRO, Ana Flávia Ribeiro et al. Effect of Arrabidaea chica extracts on the ehrlich solid tumor development. Revista Brasileira Farmacognosia. 2012, vol.22, n.2, pp. 364-373 102-695X
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7840
dc.identifier.issn.none.fl_str_mv 0102-695X
dc.identifier.doi.none.fl_str_mv 10.1590/S0102-695X2011005000225
identifier_str_mv RIBEIRO, Ana Flávia Ribeiro et al. Effect of Arrabidaea chica extracts on the ehrlich solid tumor development. Revista Brasileira Farmacognosia. 2012, vol.22, n.2, pp. 364-373 102-695X
0102-695X
10.1590/S0102-695X2011005000225
url https://www.arca.fiocruz.br/handle/icict/7840
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Universidade Federal do Paraná
publisher.none.fl_str_mv Universidade Federal do Paraná
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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