Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018

Detalhes bibliográficos
Autor(a) principal: Cantelli, Carina Pacheco
Data de Publicação: 2020
Outros Autores: Velloso, Alvaro Jorge, Assis, Rosane Maria Santos de, Barros, José Júnior, Mello, Francisco Campello do Amaral, Cunha, Denise Cotrim da, Brasil, Patrícia, Nordgren, Johan, Svensson, Lennart, Miagostovich, Marize Pereira, Leite, José Paulo Gagliardi, Moraes, Marcia Terezinha Baroni de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/41679
Resumo: Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
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spelling Cantelli, Carina PachecoVelloso, Alvaro JorgeAssis, Rosane Maria Santos deBarros, José JúniorMello, Francisco Campello do AmaralCunha, Denise Cotrim daBrasil, PatríciaNordgren, JohanSvensson, LennartMiagostovich, Marize PereiraLeite, José Paulo GagliardiMoraes, Marcia Terezinha Baroni de2020-06-16T21:42:23Z2020-06-16T21:42:23Z2020CANTELLI, Carina Pacheco et al. Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018. Scientific Reports, v. 10, n. 1, p. 1-10, 2020.2045-2322https://www.arca.fiocruz.br/handle/icict/4167910.1038/s41598-020-64025-0engNature ResearchRotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatite Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Linköping University. Department of Clinical and Experimental Medicine. Division of Molecular Virology. Linköping, Sweden.Linköping University. Department of Clinical and Experimental Medicine. Division of Molecular Virology. Linköping, Sweden.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.Recent studies have investigated whether the human histo-blood group antigen (HBGAs) could affect the effectiveness of the oral rotavirus vaccines, suggesting secretor positive individuals develop a more robust response. We investigated the Rotavirus A (RVA) shedding in association with the host susceptibility profile in children from a birth community-cohort in Rio de Janeiro, Brazil, from 2014 to 2018. A total of 132 children were followed-up between 0 to 11-month-old, stool samples were collected before/after the 1st/2nd RV1 vaccination doses and saliva samples were collected during the study. RVA shedding was screened by RT-qPCR and G/P genotypes determined by multiplex RT-PCR and/or Sanger nucleotide sequencing. The sequencing indicated an F167L amino acid change in the RV1 VP8* P[8] in 20.5% of shedding follow-ups and these mutant subpopulations were quantified by pyrosequencing. The HBGA/secretor status was determined and 80.3% of the children were secretors. Twenty-one FUT2 gene SNPs were identified and two new mutations were observed. The mutant F167L RV1 VP8* P[8] was detected significantly more in Le (a+b+) secretors (90.5%) compared to non-secretors and even to secretors Le (a-b+) (9.5%). The study highlights the probable association between RV1 shedding and HBGAs as a marker for evaluating vaccine strain host susceptibility.Rotavirus AHisto-blood group antigenSequencingGastrointestinal diseasesLive attenuated vaccinesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/41679/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALRotavirus_Patricia_Brasil_etal_INI_2020.pdfRotavirus_Patricia_Brasil_etal_INI_2020.pdfapplication/pdf1364804https://www.arca.fiocruz.br/bitstream/icict/41679/2/Rotavirus_Patricia_Brasil_etal_INI_2020.pdf29d6c7ba9bb2b779b358726797cdf652MD52TEXTRotavirus_Patricia_Brasil_etal_INI_2020.pdf.txtRotavirus_Patricia_Brasil_etal_INI_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
title Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
spellingShingle Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
Cantelli, Carina Pacheco
Rotavirus A
Histo-blood group antigen
Sequencing
Gastrointestinal diseases
Live attenuated vaccines
title_short Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
title_full Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
title_fullStr Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
title_full_unstemmed Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
title_sort Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018
author Cantelli, Carina Pacheco
author_facet Cantelli, Carina Pacheco
Velloso, Alvaro Jorge
Assis, Rosane Maria Santos de
Barros, José Júnior
Mello, Francisco Campello do Amaral
Cunha, Denise Cotrim da
Brasil, Patrícia
Nordgren, Johan
Svensson, Lennart
Miagostovich, Marize Pereira
Leite, José Paulo Gagliardi
Moraes, Marcia Terezinha Baroni de
author_role author
author2 Velloso, Alvaro Jorge
Assis, Rosane Maria Santos de
Barros, José Júnior
Mello, Francisco Campello do Amaral
Cunha, Denise Cotrim da
Brasil, Patrícia
Nordgren, Johan
Svensson, Lennart
Miagostovich, Marize Pereira
Leite, José Paulo Gagliardi
Moraes, Marcia Terezinha Baroni de
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cantelli, Carina Pacheco
Velloso, Alvaro Jorge
Assis, Rosane Maria Santos de
Barros, José Júnior
Mello, Francisco Campello do Amaral
Cunha, Denise Cotrim da
Brasil, Patrícia
Nordgren, Johan
Svensson, Lennart
Miagostovich, Marize Pereira
Leite, José Paulo Gagliardi
Moraes, Marcia Terezinha Baroni de
dc.subject.en.pt_BR.fl_str_mv Rotavirus A
Histo-blood group antigen
Sequencing
Gastrointestinal diseases
Live attenuated vaccines
topic Rotavirus A
Histo-blood group antigen
Sequencing
Gastrointestinal diseases
Live attenuated vaccines
description Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Comparada e Ambiental. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-06-16T21:42:23Z
dc.date.available.fl_str_mv 2020-06-16T21:42:23Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CANTELLI, Carina Pacheco et al. Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018. Scientific Reports, v. 10, n. 1, p. 1-10, 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/41679
dc.identifier.issn.pt_BR.fl_str_mv 2045-2322
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-020-64025-0
identifier_str_mv CANTELLI, Carina Pacheco et al. Rotavirus A shedding and HBGA host genetic susceptibility in a birth community-cohort, Rio de Janeiro, Brazil, 2014-2018. Scientific Reports, v. 10, n. 1, p. 1-10, 2020.
2045-2322
10.1038/s41598-020-64025-0
url https://www.arca.fiocruz.br/handle/icict/41679
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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https://www.arca.fiocruz.br/bitstream/icict/41679/2/Rotavirus_Patricia_Brasil_etal_INI_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/41679/3/Rotavirus_Patricia_Brasil_etal_INI_2020.pdf.txt
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