Origin and evolution of dengue virus type 3 in Brazil

Detalhes bibliográficos
Autor(a) principal: Araújo, Josélio Maria Galvão de
Data de Publicação: 2012
Outros Autores: Bello, Gonzalo, Romero, Hector, Nogueira, Rita Maria Ribeiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/15810
Resumo: Universidade Federal do Rio Grande do Norte. Laboratório de Biologia Molecular para Doenças Infecciosas e Câncer. Natal, RN, Brasil.
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spelling Araújo, Josélio Maria Galvão deBello, GonzaloRomero, HectorNogueira, Rita Maria Ribeiro2016-09-15T14:23:10Z2016-09-15T14:23:10Z2012ARAÚJO, Josélio Maria Galvão de; et al. Origin and Evolution of Dengue Virus Type 3 in Brazil. PLoS Negl Trop Dis., v.6, n.9, e1784, 10p, Sept. 2012.1935-2727https://www.arca.fiocruz.br/handle/icict/1581010.1371/journal.pntd.00017841935-2735engPublic Library of ScienceDengueDengue tipo3BrasilVigilância epidemiológicaDengue Virus Type 3BrazilEpidemiological surveillanceOrigin and evolution of dengue virus type 3 in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio Grande do Norte. Laboratório de Biologia Molecular para Doenças Infecciosas e Câncer. Natal, RN, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Universidad de la República. Facultad de Ciencias. Laboratório de Organización y Evolución del Genoma. Sección Biomatemáticas. Montevideo, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.The incidence of dengue fever and dengue hemorrhagic fever in Brazil experienced a significant increase since the emergence of dengue virus type-3 (DENV-3) at the early 2000s. Despite the major public health concerns, there have been very few studies of the molecular epidemiology and time-scale of this DENV lineage in Brazil. In this study, we investigated the origin and dispersion dynamics of DENV-3 genotype III in Brazil by examining a large number (n=107) of E gene sequences sampled between 2001 and 2009 from diverse Brazilian regions. These Brazilian sequences were combined with 457 DENV-3 genotype III E gene sequences from 29 countries around the world. Our phylogenetic analysis reveals that there have been at least four introductions of the DENV-3 genotype III in Brazil, as signified by the presence of four phylogenetically distinct lineages. Three lineages (BR-I, BR-II, and BR-III) were probably imported from the Lesser Antilles (Caribbean), while the fourth one (BR-IV) was probably introduced from Colombia or Venezuela. While lineages BR-I and BR-II succeeded in getting established and disseminated in Brazil and other countries from the Southern Cone, lineages BR-III and BR-IV were only detected in one single individual each from the North region. The phylogeographic analysis indicates that DENV-3 lineages BR-I and BR-II were most likely introduced into Brazil through the Southeast and North regions around 1999 (95% HPD: 1998-2000) and 2001 (95% HPD: 2000-2002), respectively. These findings show that importation of DENV-3 lineages from the Caribbean islands into Brazil seems to be relatively frequent. Our study further suggests that the North and Southeast Brazilian regions were the most important hubs of introduction and spread of DENV-3 lineages and deserve an intense epidemiological surveillance.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15810/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgonzalo3_bello_etal_IOC_2012.pdfgonzalo3_bello_etal_IOC_2012.pdfapplication/pdf861973https://www.arca.fiocruz.br/bitstream/icict/15810/2/gonzalo3_bello_etal_IOC_2012.pdf44f514ca14f66b506635797d554f42cdMD52TEXTgonzalo3_bello_etal_IOC_2012.pdf.txtgonzalo3_bello_etal_IOC_2012.pdf.txtExtracted texttext/plain43006https://www.arca.fiocruz.br/bitstream/icict/15810/3/gonzalo3_bello_etal_IOC_2012.pdf.txta6750480741058f1bc84a102f7cc81d4MD53icict/158102018-04-02 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dc.title.pt_BR.fl_str_mv Origin and evolution of dengue virus type 3 in Brazil
title Origin and evolution of dengue virus type 3 in Brazil
spellingShingle Origin and evolution of dengue virus type 3 in Brazil
Araújo, Josélio Maria Galvão de
Dengue
Dengue tipo3
Brasil
Vigilância epidemiológica
Dengue Virus Type 3
Brazil
Epidemiological surveillance
title_short Origin and evolution of dengue virus type 3 in Brazil
title_full Origin and evolution of dengue virus type 3 in Brazil
title_fullStr Origin and evolution of dengue virus type 3 in Brazil
title_full_unstemmed Origin and evolution of dengue virus type 3 in Brazil
title_sort Origin and evolution of dengue virus type 3 in Brazil
author Araújo, Josélio Maria Galvão de
author_facet Araújo, Josélio Maria Galvão de
Bello, Gonzalo
Romero, Hector
Nogueira, Rita Maria Ribeiro
author_role author
author2 Bello, Gonzalo
Romero, Hector
Nogueira, Rita Maria Ribeiro
author2_role author
author
author
dc.contributor.author.fl_str_mv Araújo, Josélio Maria Galvão de
Bello, Gonzalo
Romero, Hector
Nogueira, Rita Maria Ribeiro
dc.subject.other.pt_BR.fl_str_mv Dengue
Dengue tipo3
Brasil
Vigilância epidemiológica
topic Dengue
Dengue tipo3
Brasil
Vigilância epidemiológica
Dengue Virus Type 3
Brazil
Epidemiological surveillance
dc.subject.en.pt_BR.fl_str_mv Dengue Virus Type 3
Brazil
Epidemiological surveillance
description Universidade Federal do Rio Grande do Norte. Laboratório de Biologia Molecular para Doenças Infecciosas e Câncer. Natal, RN, Brasil.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-09-15T14:23:10Z
dc.date.available.fl_str_mv 2016-09-15T14:23:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO, Josélio Maria Galvão de; et al. Origin and Evolution of Dengue Virus Type 3 in Brazil. PLoS Negl Trop Dis., v.6, n.9, e1784, 10p, Sept. 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/15810
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0001784
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv ARAÚJO, Josélio Maria Galvão de; et al. Origin and Evolution of Dengue Virus Type 3 in Brazil. PLoS Negl Trop Dis., v.6, n.9, e1784, 10p, Sept. 2012.
1935-2727
10.1371/journal.pntd.0001784
1935-2735
url https://www.arca.fiocruz.br/handle/icict/15810
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/15810/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/15810/2/gonzalo3_bello_etal_IOC_2012.pdf
https://www.arca.fiocruz.br/bitstream/icict/15810/3/gonzalo3_bello_etal_IOC_2012.pdf.txt
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