Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome

Detalhes bibliográficos
Autor(a) principal: Leite, Pauline Martins
Data de Publicação: 2012
Outros Autores: Gomes, Rodrigo Saar, Figueiredo, Amanda Braga de, Serafim, Tiago Donatelli, Moura, Sandra Aparecida Lima de, Afonso, Luís Carlos Crocco, Tafuri, Wagner Luiz, Souza, Carolina Carvalho de, Fietto, Juliana Lopes Rangel, Melo, Maria Norma, Dias, Fátima Ribeiro, Oliveira, Milton Adriano Pelli de, Rabello, Ana Lúcia Teles
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7646
Resumo: Universidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, Brazil
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spelling Leite, Pauline MartinsGomes, Rodrigo SaarFigueiredo, Amanda Braga deSerafim, Tiago DonatelliMoura, Sandra Aparecida Lima deAfonso, Luís Carlos CroccoTafuri, Wagner LuizSouza, Carolina Carvalho deFietto, Juliana Lopes RangelMelo, Maria NormaDias, Fátima RibeiroOliveira, Milton Adriano Pelli deRabello, Ana Lúcia Teles2014-05-23T16:11:22Z2014-05-23T16:11:22Z2012LEITE, Pauline Martins et al. Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome. Plos Neglected Tropical Diseases. 2012, vol.6, pp. e18501935-2735https://www.arca.fiocruz.br/handle/icict/764610.1371/journal.pntd.0001850engPublic Library of ScienceEcto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcomeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, BrazilUniversidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Patologia Geral. Belo Horizonte, MG, BrazilUniversidade Federal de Viçosa. Departamento de Bioquímica e Biologia Molecular. Viçosa, MG, BrazilUniversidade Federal de Minas Gerais. Belo Horizonte, MG, BrazilUniversidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Publica. Goiânia, Go, BrazilUniversidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Publica. Goiânia, Go, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilCutaneous leishmaniasis is a widespread tropical disease caused by different species of Leishmania protozoa that are transmitted by infected sandflies. Clinical presentations are extremely diverse and dependent on a variety of parasite and host factors that are poorly understood. Leishmania (V.) braziliensis infection may result in a devastating disease manifestation characterized by the development of destructive lesions in the oral, nasal, and pharyngeal mucosal. Ecto-nucleotidases are enzymes that are involved in the hydrolysis of extracellular nucleotides. These enzymes have been shown to correlate with virulence of Leishmania parasites. In this work, we evaluated the ecto-nucleotidase activity of promastigotes from the twenty three different L. braziliensis isolates. We demonstrated that isolates obtained from mucosal lesions present higher levels of ecto-nucleotidase activity than those from cutaneous lesions. In addition, we show that in the murine model of cutaneous leishmaniasis, promastigote forms of parasite with higher activity induce a delayed/decreased immune response that may correlate with spreading of the parasites throughout the body. Thus, we propose that the level of ecto-nucleotidase activity of promastigotes may be a marker for the development of severe clinical forms of cutaneous leishmaniasis and also a possible target for future therapeutic intervention.PromastigoteLeishmaniaParasites/ResearchDisease/progressionParasitisminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALEcto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome.pdfEcto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome.pdfapplication/pdf3839228https://www.arca.fiocruz.br/bitstream/icict/7646/1/Ecto-nucleotidase%20activities%20of%20promastigotes%20from%20Leishmania%20%28Viannia%29%20braziliensis%20relates%20to%20parasite%20infectivity%20and%20disease%20clinical%20outcome.pdf771088c9daadc1084556c22bd2e1afb4MD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
title Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
spellingShingle Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
Leite, Pauline Martins
Promastigote
Leishmania
Parasites/Research
Disease/progression
Parasitism
title_short Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
title_full Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
title_fullStr Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
title_full_unstemmed Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
title_sort Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome
author Leite, Pauline Martins
author_facet Leite, Pauline Martins
Gomes, Rodrigo Saar
Figueiredo, Amanda Braga de
Serafim, Tiago Donatelli
Moura, Sandra Aparecida Lima de
Afonso, Luís Carlos Crocco
Tafuri, Wagner Luiz
Souza, Carolina Carvalho de
Fietto, Juliana Lopes Rangel
Melo, Maria Norma
Dias, Fátima Ribeiro
Oliveira, Milton Adriano Pelli de
Rabello, Ana Lúcia Teles
author_role author
author2 Gomes, Rodrigo Saar
Figueiredo, Amanda Braga de
Serafim, Tiago Donatelli
Moura, Sandra Aparecida Lima de
Afonso, Luís Carlos Crocco
Tafuri, Wagner Luiz
Souza, Carolina Carvalho de
Fietto, Juliana Lopes Rangel
Melo, Maria Norma
Dias, Fátima Ribeiro
Oliveira, Milton Adriano Pelli de
Rabello, Ana Lúcia Teles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Leite, Pauline Martins
Gomes, Rodrigo Saar
Figueiredo, Amanda Braga de
Serafim, Tiago Donatelli
Moura, Sandra Aparecida Lima de
Afonso, Luís Carlos Crocco
Tafuri, Wagner Luiz
Souza, Carolina Carvalho de
Fietto, Juliana Lopes Rangel
Melo, Maria Norma
Dias, Fátima Ribeiro
Oliveira, Milton Adriano Pelli de
Rabello, Ana Lúcia Teles
dc.subject.en.pt_BR.fl_str_mv Promastigote
Leishmania
Parasites/Research
Disease/progression
Parasitism
topic Promastigote
Leishmania
Parasites/Research
Disease/progression
Parasitism
description Universidade Federal de Ouro Preto. Laboratório de Imunoparasitologia. Ouro Preto, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-05-23T16:11:22Z
dc.date.available.fl_str_mv 2014-05-23T16:11:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LEITE, Pauline Martins et al. Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome. Plos Neglected Tropical Diseases. 2012, vol.6, pp. e1850
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7646
dc.identifier.issn.none.fl_str_mv 1935-2735
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0001850
identifier_str_mv LEITE, Pauline Martins et al. Ecto-nucleotidase activities of promastigotes from Leishmania (Viannia) braziliensis relates to parasite infectivity and disease clinical outcome. Plos Neglected Tropical Diseases. 2012, vol.6, pp. e1850
1935-2735
10.1371/journal.pntd.0001850
url https://www.arca.fiocruz.br/handle/icict/7646
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/7646/1/Ecto-nucleotidase%20activities%20of%20promastigotes%20from%20Leishmania%20%28Viannia%29%20braziliensis%20relates%20to%20parasite%20infectivity%20and%20disease%20clinical%20outcome.pdf
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