The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains

Detalhes bibliográficos
Autor(a) principal: Rangel, Héctor R.
Data de Publicação: 2015
Outros Autores: Bello, Gonzalo, Villalba, Julian A., Sulbaran, Yoneira F., Garzaro, Domingo, Maes, Mailis, Loureiro, Carmen L., de Waard, Jacobus H., Pujol, Flor H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12359
Resumo: 2016-10-31
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spelling Rangel, Héctor R.Bello, GonzaloVillalba, Julian A.Sulbaran, Yoneira F.Garzaro, DomingoMaes, MailisLoureiro, Carmen L.de Waard, Jacobus H.Pujol, Flor H.2015-12-08T13:29:04Z2015RANGEL, Héctor R. et al.The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains. AIDS Research and Human Retroviruses, v.31, n.12, p.1265-1268, Nov. 2015.0889-2229https://www.arca.fiocruz.br/handle/icict/1235910.1089/aid.2015.01551931-8405engMary Ann LiebertHIVVenezuelaTuberculoseHIV-1Warao AmerindiansVenezuelaAIDSTuberculosisThe Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2016-10-31Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Instituto de Biomedicina. Laboratorio de Tuberculosis. Caracas, Venezuela / Harvard Medical School. Brigham and Women’s Hospital. Division of Pulmonary and Critical Care Medicine. Boston, Massachusetts, USA.Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela.Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela.Instituto de Biomedicina. Laboratorio de Tuberculosis. Caracas, Venezuela / University of Cambridge. Department of Medicine. Cambridge, United Kingdom.Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela.Instituto de Biomedicina. Laboratorio de Tuberculosis. Caracas, Venezuela.Instituto Venezolano de Investigaciones Científicas. Laboratorio de Virología Molecular. Caracas, Venezuela.We previously reported a high prevalence of HIV-1 infection in Warao Amerindians from Venezuela due to the rapid spread of a single B subtype strain. In this study we evaluated the coreceptor use of the HIV-1 strains infecting this Amerindian community. Sequences of the HIV-1 V3 loop from 56 plasma samples were genotyped for coreceptor use. An extremely high frequency of CXCR4 strains was found among HIV-1-infecting Waraos (47/49, 96%), compared to HIV-1 strains infecting the non-Amerindian Venezuelan population (35/79, 44%, p < 0.00001). Evolutionary analysis showed that a significant number of infections occurred between 1 and 12 months before collection and that a great proportion (50–70%) of HIV-1 transmissions occurred within the very early phase of infection (£12 months). This is consistent with an initial infection dominated by an X4 strain or a very rapid selection of X4 variants after infection. This Amerindian population also exhibits the highest prevalence of tuberculosis in Venezuela, being synergistically bad prognostic factors for the evolution of morbidity and mortality in this vulnerable population.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12359/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALgonzalo_bello_etal_IOC_2015.pdfgonzalo_bello_etal_IOC_2015.pdfapplication/pdf206067https://www.arca.fiocruz.br/bitstream/icict/12359/2/gonzalo_bello_etal_IOC_2015.pdf54aef9f5a3aa4951ac3d6c1e977e93f2MD52TEXTgonzalo_bello_etal_IOC_2015.pdf.txtgonzalo_bello_etal_IOC_2015.pdf.txtExtracted texttext/plain18268https://www.arca.fiocruz.br/bitstream/icict/12359/3/gonzalo_bello_etal_IOC_2015.pdf.txtb8aa0e19965e1bc915093be755d1dbb1MD53icict/123592021-03-24 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dc.title.pt_BR.fl_str_mv The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
title The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
spellingShingle The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
Rangel, Héctor R.
HIV
Venezuela
Tuberculose
HIV-1
Warao Amerindians
Venezuela
AIDS
Tuberculosis
title_short The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
title_full The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
title_fullStr The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
title_full_unstemmed The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
title_sort The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains
author Rangel, Héctor R.
author_facet Rangel, Héctor R.
Bello, Gonzalo
Villalba, Julian A.
Sulbaran, Yoneira F.
Garzaro, Domingo
Maes, Mailis
Loureiro, Carmen L.
de Waard, Jacobus H.
Pujol, Flor H.
author_role author
author2 Bello, Gonzalo
Villalba, Julian A.
Sulbaran, Yoneira F.
Garzaro, Domingo
Maes, Mailis
Loureiro, Carmen L.
de Waard, Jacobus H.
Pujol, Flor H.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rangel, Héctor R.
Bello, Gonzalo
Villalba, Julian A.
Sulbaran, Yoneira F.
Garzaro, Domingo
Maes, Mailis
Loureiro, Carmen L.
de Waard, Jacobus H.
Pujol, Flor H.
dc.subject.other.pt_BR.fl_str_mv HIV
Venezuela
Tuberculose
topic HIV
Venezuela
Tuberculose
HIV-1
Warao Amerindians
Venezuela
AIDS
Tuberculosis
dc.subject.en.pt_BR.fl_str_mv HIV-1
Warao Amerindians
Venezuela
AIDS
Tuberculosis
description 2016-10-31
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-12-08T13:29:04Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RANGEL, Héctor R. et al.The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains. AIDS Research and Human Retroviruses, v.31, n.12, p.1265-1268, Nov. 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12359
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.doi.none.fl_str_mv 10.1089/aid.2015.0155
dc.identifier.eissn.none.fl_str_mv 1931-8405
identifier_str_mv RANGEL, Héctor R. et al.The Evolving HIV-1 Epidemic in Warao Amerindians Is Dominated by an Extremely High Frequency of CXCR4-Utilizing Strains. AIDS Research and Human Retroviruses, v.31, n.12, p.1265-1268, Nov. 2015.
0889-2229
10.1089/aid.2015.0155
1931-8405
url https://www.arca.fiocruz.br/handle/icict/12359
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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