Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities

Bibliographic Details
Main Author: Meira, Cássio Santana
Publication Date: 2015
Other Authors: Guimarães, Elisalva Teixeira, Macedo, Taís Soares, Silva, Thanany Brasil da, Menezes, Leociley Rocha Alencar, Costa, Emmanoel Vilaça, Soares, Milena Botelho Pereira
Format: Article
Language: eng
Source: Repositório Institucional da FIOCRUZ (ARCA)
DOI: dx.doi.org/10.1080/10412905.2014.982876
Download full: https://www.arca.fiocruz.br/handle/icict/14262
Summary: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Meira, Cássio SantanaGuimarães, Elisalva TeixeiraMacedo, Taís SoaresSilva, Thanany Brasil daMenezes, Leociley Rocha AlencarCosta, Emmanoel VilaçaSoares, Milena Botelho Pereira2016-05-12T18:50:46Z2016-05-12T18:50:46Z2015MEIRA, C. S. et al. Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities. Journal of Essential Oil Research, v. 27, n. 2, p. 160–168, 2015.1041-2905https://www.arca.fiocruz.br/handle/icict/14262dx.doi.org/10.1080/10412905.2014.982876engTaylor & FrancisChemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activitiesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Universidade do Estado da Bahia. Departamento de Ciências da Vida. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, BrasilUniversidade Federal de Sergipe. Departamento de Química. São Cristovão, SE, BrasilUniversidade Federal de Sergipe. Departamento de Química. Itabaiana, SE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, BrasilHere, we describe the trypanocidal and antimalarial activities from essential oils extracted from Annona vepretorum (AVOE) and Annona squamosa (ASOE) (Annonaceae) leaves. The essential oils were obtained by hydrodistillation and analyzed by gas chromatography–mass spectrometry (GC–MS) and GC–flame ionization detection (GC–FID). A total of twenty-one compounds were identified in AVOE and twenty-three in ASOE. The sesquiterpenes are more abundant in the both essential oils. ASOE contained significant quantities of (E)-caryophyllene (27.4%), germacrene D (17.1%) and bicyclogermacrene (10.8%). The major compounds in AVOE were bicyclogermacrene (39.0%), spathulenol (14.0%) and α-phellandrene (11.5%). The essential oils demonstrated potent trypanocidal and antimalarial activities with values of IC50 lower than 20 μg/mL, and a strong inhibition of the proliferation of amastigotes, the clinically relevant forms of Trypanosoma cruzi. In addition, through ultrastructural studies and flow cytometry analysis with trypomastigotes of T. cruzi, we identified significant ultrastructural alterations induced by the essential oils, especially in the cell membrane and mitochondria, which ultimately results in necrotic parasite deathAnnona squamosaAnnona vepretorumEssential oilAntimalarial activity; trypanocidal activityinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/14262/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMeira CS Chemical....pdfMeira CS Chemical....pdfapplication/pdf603682https://www.arca.fiocruz.br/bitstream/icict/14262/2/Meira%20CS%20%20Chemical....pdfed19b9fa64b4003b817d092a3fff3ac6MD52TEXTMeira CS Chemical....pdf.txtMeira CS Chemical....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
title Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
spellingShingle Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
Meira, Cássio Santana
Annona squamosa
Annona vepretorum
Essential oil
Antimalarial activity; trypanocidal activity
title_short Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
title_full Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
title_fullStr Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
title_full_unstemmed Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
title_sort Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities
author Meira, Cássio Santana
author_facet Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Macedo, Taís Soares
Silva, Thanany Brasil da
Menezes, Leociley Rocha Alencar
Costa, Emmanoel Vilaça
Soares, Milena Botelho Pereira
author_role author
author2 Guimarães, Elisalva Teixeira
Macedo, Taís Soares
Silva, Thanany Brasil da
Menezes, Leociley Rocha Alencar
Costa, Emmanoel Vilaça
Soares, Milena Botelho Pereira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Macedo, Taís Soares
Silva, Thanany Brasil da
Menezes, Leociley Rocha Alencar
Costa, Emmanoel Vilaça
Soares, Milena Botelho Pereira
dc.subject.en.pt_BR.fl_str_mv Annona squamosa
Annona vepretorum
Essential oil
Antimalarial activity; trypanocidal activity
topic Annona squamosa
Annona vepretorum
Essential oil
Antimalarial activity; trypanocidal activity
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2016-05-12T18:50:46Z
dc.date.available.fl_str_mv 2016-05-12T18:50:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MEIRA, C. S. et al. Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities. Journal of Essential Oil Research, v. 27, n. 2, p. 160–168, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/14262
dc.identifier.issn.none.fl_str_mv 1041-2905
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1080/10412905.2014.982876
identifier_str_mv MEIRA, C. S. et al. Chemical composition of essential oils from Annona vepretorum Mart. and Annona squamosa L. (Annonaceae) leaves and their antimalarial and trypanocidal activities. Journal of Essential Oil Research, v. 27, n. 2, p. 160–168, 2015.
1041-2905
dx.doi.org/10.1080/10412905.2014.982876
url https://www.arca.fiocruz.br/handle/icict/14262
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/14262/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/14262/2/Meira%20CS%20%20Chemical....pdf
https://www.arca.fiocruz.br/bitstream/icict/14262/3/Meira%20CS%20%20Chemical....pdf.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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