Heme crystallization in the midgut of triatomine insects

Detalhes bibliográficos
Autor(a) principal: Oliveira, Marcus Fernandes de
Data de Publicação: 2007
Outros Autores: Gandara, Ana Caroline Paiva, Braga, Claudia M. S, Silva, José Roberto da, Dansa-Petretski, Marílvia, Menezes, Diego, Santos, Marcos André Vannier dos, Oliveira, Pedro Lagerblad de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10442
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil
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spelling Oliveira, Marcus Fernandes deGandara, Ana Caroline PaivaBraga, Claudia M. SSilva, José Roberto daDansa-Petretski, MarílviaMenezes, DiegoSantos, Marcos André Vannier dosOliveira, Pedro Lagerblad de2015-05-20T18:02:53Z2015-05-20T18:02:53Z2007OLIVEIRA, M. F. de. Heme crystallization in the midgut of triatomine insects. Comparative Biochemistry and Physiology. C, Toxicology & Pharmacology, v. 146, n. 1-2, p. 168-174, 2007.1532-0456https://www.arca.fiocruz.br/handle/icict/10442engElsevierHeme crystallization in the midgut of triatomine insectsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, BrasilPetrobrás. CENPES. Setor de Química. Rio de Janeiro, RJ, BrasilUniversidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Campos de Goytacazes, RJ, BrasilUniversidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Campos de Goytacazes, RJ, BrasilUniversidade Estadual do Norte Fluminense. Centro de Biociências e Biotecnologia. Campos de Goytacazes, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, BrasilHemozoin (Hz) is a heme crystal produced by several blood-feeding organisms in order to detoxify free heme released upon hemoglobin (Hb) digestion. Here we show that heme crystallization also occurs in three species of triatomine insects. Ultraviolet-visible and infrared light absorption spectra of insoluble pigments isolated from the midgut of three triatomine species Triatoma infestans, Dipetalogaster maximus and Panstrongylus megistus indicated that all produce Hz. Morphological analysis of T. infestans and D. maximus midguts revealed the close association of Hz crystals to perimicrovillar membranes and also as multicrystalline assemblies, forming nearly spherical structures. Heme crystallization was promoted by isolated perimicrovillar membranes from all three species of triatomine bugs in vitro in heat-sensitive reactions. In conclusion, the data presented here indicate that Hz formation is an ancestral adaptation of Triatominae to a blood-sucking habit and that the presence of perimicrovillar membranes plays a central role in this process. © 2007 Elsevier Inc. All rights reservedTriatominaeHemeHemozoinPerimicrovillar membranesMidgutHemeHemeproteínasPigmentos BiológicosTriatominaeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10442/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALOliveira MF Heme crystalization in the midgut......pdfOliveira MF Heme crystalization in the midgut......pdfapplication/pdf470893https://www.arca.fiocruz.br/bitstream/icict/10442/2/Oliveira%20MF%20Heme%20crystalization%20in%20the%20midgut......pdf07f8324e561a2a3503de46cea2de522cMD52TEXTOliveira MF Heme crystalization in the midgut......pdf.txtOliveira MF Heme crystalization in the midgut......pdf.txtExtracted texttext/plain30919https://www.arca.fiocruz.br/bitstream/icict/10442/3/Oliveira%20MF%20Heme%20crystalization%20in%20the%20midgut......pdf.txt92cdcede572ddbdeec693924d13f6cfcMD53icict/104422023-03-15 14:33:08.715oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:08Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Heme crystallization in the midgut of triatomine insects
title Heme crystallization in the midgut of triatomine insects
spellingShingle Heme crystallization in the midgut of triatomine insects
Oliveira, Marcus Fernandes de
Triatominae
Heme
Hemozoin
Perimicrovillar membranes
Midgut
Heme
Hemeproteínas
Pigmentos Biológicos
Triatominae
title_short Heme crystallization in the midgut of triatomine insects
title_full Heme crystallization in the midgut of triatomine insects
title_fullStr Heme crystallization in the midgut of triatomine insects
title_full_unstemmed Heme crystallization in the midgut of triatomine insects
title_sort Heme crystallization in the midgut of triatomine insects
author Oliveira, Marcus Fernandes de
author_facet Oliveira, Marcus Fernandes de
Gandara, Ana Caroline Paiva
Braga, Claudia M. S
Silva, José Roberto da
Dansa-Petretski, Marílvia
Menezes, Diego
Santos, Marcos André Vannier dos
Oliveira, Pedro Lagerblad de
author_role author
author2 Gandara, Ana Caroline Paiva
Braga, Claudia M. S
Silva, José Roberto da
Dansa-Petretski, Marílvia
Menezes, Diego
Santos, Marcos André Vannier dos
Oliveira, Pedro Lagerblad de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Marcus Fernandes de
Gandara, Ana Caroline Paiva
Braga, Claudia M. S
Silva, José Roberto da
Dansa-Petretski, Marílvia
Menezes, Diego
Santos, Marcos André Vannier dos
Oliveira, Pedro Lagerblad de
dc.subject.en.pt_BR.fl_str_mv Triatominae
Heme
Hemozoin
Perimicrovillar membranes
Midgut
topic Triatominae
Heme
Hemozoin
Perimicrovillar membranes
Midgut
Heme
Hemeproteínas
Pigmentos Biológicos
Triatominae
dc.subject.decs.pt_BR.fl_str_mv Heme
Hemeproteínas
Pigmentos Biológicos
Triatominae
description Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica. Rio de Janeiro, RJ, Brasil
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2015-05-20T18:02:53Z
dc.date.available.fl_str_mv 2015-05-20T18:02:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, M. F. de. Heme crystallization in the midgut of triatomine insects. Comparative Biochemistry and Physiology. C, Toxicology & Pharmacology, v. 146, n. 1-2, p. 168-174, 2007.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10442
dc.identifier.issn.none.fl_str_mv 1532-0456
identifier_str_mv OLIVEIRA, M. F. de. Heme crystallization in the midgut of triatomine insects. Comparative Biochemistry and Physiology. C, Toxicology & Pharmacology, v. 146, n. 1-2, p. 168-174, 2007.
1532-0456
url https://www.arca.fiocruz.br/handle/icict/10442
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/10442/1/license.txt
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https://www.arca.fiocruz.br/bitstream/icict/10442/3/Oliveira%20MF%20Heme%20crystalization%20in%20the%20midgut......pdf.txt
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