A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56186 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. |
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Giovanetti, MartaPereira, Luiz AugustoAdelino, Talita Émile RibeiroFonseca, VagnerXavier, JoilsonFabri, Allison de AraújoSlavov, Svetoslav NanevLemos, Poliana da SilvaMarques, William de AlmeidaKashima, SimoneLourenço, JoséOliveira, Tulio deAlbuquerque, Carlos Frederico Campelo deFreitas, CarlaPeterka, Cassio Roberto LeonelCunha, Rivaldo Venancio daMendonça, Ana FláviaSilva, Vinícius Lemes daAlcântara, Luiz Carlos Junior2022-12-23T13:40:17Z2022-12-23T13:40:17Z2022GIOVANETTI, Marta et al. A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil. Microbiology Spectrum, v. 10, n. 2, p. 1 - 6, Mar./Apr. 2022.2165-0497https://www.arca.fiocruz.br/handle/icict/5618610.1128/spectrum.00155-22engAmerican Society for MicrobiologyZika vírusLInhagem asiáticaCentro-Oeste brasileiroEpidemiologia genômicaZika virusAsian lineageMidwest BrazilGenomic epidemiologyA Retrospective Overview of Zika Virus Evolution in the Midwest of Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros. Goiânia, GO, Brasil.Fundação Ezequiel Dias. Laboratório Central de Saúde Pública. Belo Horizonte, MG, Brasil.Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, DF, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Coordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde (CGARB/SVS-MS). Brasília, DF, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Escola de Medicina de Ribeirão Preto. Hemocentro de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Department of Zoology, Peter Medawar Building, University of Oxford, Oxford, UK.School for Data Science and Computational Thinking, Faculty of Science and Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa.Organização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, DF, Brasil.Coordenação Geral de Laboratórios de Saúde Pública/Secretaria de Vigilância em Saúde, Ministério da Saúde (CGLAB/SVS-MS), Brasília, DF, Brasil.Coordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde (CGARB/SVS-MS), Brasília, DF.Brasil.Fundação Oswaldo Cruz, Bio-Manguinhos, Rio de Janeiro, RJ, Brasil.Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros, Goiânia, GO, Brasil.Laboratório Central de Saúde Pública Dr. Giovanni Cysneiros, Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil.Since the introduction of the Zika virus (ZIKV) into Brazil in 2015, its transmission dynamics have been intensively studied in many parts of the country, although much is still unknown about its circulation in the midwestern states. Here, using nanopore technology, we obtained 23 novel partial and near-complete ZIKV genomes from the state of Goiás, located in the Midwest of Brazil. Genomic, phylogenetic, and epidemiological approaches were used to retrospectively explore the spatiotemporal evolution of the ZIKV-Asian genotype in this region. As a likely consequence of a gradual accumulation of herd immunity, epidemiological data revealed a decline in the number of reported cases over 2018 to 2021. Phylogenetic reconstructions revealed that multiple independent introductions of the Asian lineage have occurred in Goiás over time and revealed a complex transmission dynamic between epidemic seasons. Together, our results highlight the utility of genomic, epidemiological, and evolutionary methods to understand mosquito-borne epidemics. IMPORTANCE Despite the considerable morbidity and mortality of arboviral infections in Brazil, such as Zika, chikungunya, dengue fever, and yellow fever, our understanding of these outbreaks is hampered by the limited availability of genomic data to track and control the epidemic. In this study, we provide a retrospective reconstruction of the Zika virus transmission dynamics in the state of Goiás by analyzing genomic data from areas in Midwest Brazil not covered by other previous studies. Our study provides an understanding of how ZIKV initiates transmission in this region and reveals a complex transmission dynamic between epidemic seasons. Together, our results highlight the utility of genomic, epidemiological, and evolutionary methods to understand mosquitoborne epidemics, revealing how this toolkit can be used to help policymakers prioritize areas to be targeted, especially in the context of finite public health resources.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56186/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALLuizAlcantara_TuliodeOliveira_etal_IOC_2022.pdfLuizAlcantara_TuliodeOliveira_etal_IOC_2022.pdfapplication/pdf671111https://www.arca.fiocruz.br/bitstream/icict/56186/2/LuizAlcantara_TuliodeOliveira_etal_IOC_2022.pdfa7695d3cc214e5da7babddfa70a8f04cMD52icict/561862023-09-04 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| dc.title.en_US.fl_str_mv |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil |
| title |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil |
| spellingShingle |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil Giovanetti, Marta Zika vírus LInhagem asiática Centro-Oeste brasileiro Epidemiologia genômica Zika virus Asian lineage Midwest Brazil Genomic epidemiology |
| title_short |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil |
| title_full |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil |
| title_fullStr |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil |
| title_full_unstemmed |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil |
| title_sort |
A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil |
| author |
Giovanetti, Marta |
| author_facet |
Giovanetti, Marta Pereira, Luiz Augusto Adelino, Talita Émile Ribeiro Fonseca, Vagner Xavier, Joilson Fabri, Allison de Araújo Slavov, Svetoslav Nanev Lemos, Poliana da Silva Marques, William de Almeida Kashima, Simone Lourenço, José Oliveira, Tulio de Albuquerque, Carlos Frederico Campelo de Freitas, Carla Peterka, Cassio Roberto Leonel Cunha, Rivaldo Venancio da Mendonça, Ana Flávia Silva, Vinícius Lemes da Alcântara, Luiz Carlos Junior |
| author_role |
author |
| author2 |
Pereira, Luiz Augusto Adelino, Talita Émile Ribeiro Fonseca, Vagner Xavier, Joilson Fabri, Allison de Araújo Slavov, Svetoslav Nanev Lemos, Poliana da Silva Marques, William de Almeida Kashima, Simone Lourenço, José Oliveira, Tulio de Albuquerque, Carlos Frederico Campelo de Freitas, Carla Peterka, Cassio Roberto Leonel Cunha, Rivaldo Venancio da Mendonça, Ana Flávia Silva, Vinícius Lemes da Alcântara, Luiz Carlos Junior |
| author2_role |
author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Giovanetti, Marta Pereira, Luiz Augusto Adelino, Talita Émile Ribeiro Fonseca, Vagner Xavier, Joilson Fabri, Allison de Araújo Slavov, Svetoslav Nanev Lemos, Poliana da Silva Marques, William de Almeida Kashima, Simone Lourenço, José Oliveira, Tulio de Albuquerque, Carlos Frederico Campelo de Freitas, Carla Peterka, Cassio Roberto Leonel Cunha, Rivaldo Venancio da Mendonça, Ana Flávia Silva, Vinícius Lemes da Alcântara, Luiz Carlos Junior |
| dc.subject.other.en_US.fl_str_mv |
Zika vírus LInhagem asiática Centro-Oeste brasileiro Epidemiologia genômica |
| topic |
Zika vírus LInhagem asiática Centro-Oeste brasileiro Epidemiologia genômica Zika virus Asian lineage Midwest Brazil Genomic epidemiology |
| dc.subject.en.en_US.fl_str_mv |
Zika virus Asian lineage Midwest Brazil Genomic epidemiology |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. |
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2022 |
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2022-12-23T13:40:17Z |
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2022-12-23T13:40:17Z |
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2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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GIOVANETTI, Marta et al. A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil. Microbiology Spectrum, v. 10, n. 2, p. 1 - 6, Mar./Apr. 2022. |
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https://www.arca.fiocruz.br/handle/icict/56186 |
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2165-0497 |
| dc.identifier.doi.none.fl_str_mv |
10.1128/spectrum.00155-22 |
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GIOVANETTI, Marta et al. A Retrospective Overview of Zika Virus Evolution in the Midwest of Brazil. Microbiology Spectrum, v. 10, n. 2, p. 1 - 6, Mar./Apr. 2022. 2165-0497 10.1128/spectrum.00155-22 |
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American Society for Microbiology |
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American Society for Microbiology |
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