Immune modulation in primary vaccinia virus zoonotic human infections
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7954 |
Resumo: | FAPEMIG , CNPq, National Institute of Science and Technology in Vaccines |
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Gomes, Juliana de Assis SilvaAraújo, Fernanda Fortes deTrindade, Giliane de SouzaQuinan, Bárbara ResendeDrumond, Betânia PaivaFerreira, Jaqueline Maria SiqueiraMota, Bruno Eduardo FernandesNogueira, Maurício LacerdaKroon, Erna GeessienAbrahão, Jônatas SantosOliveira, Rodrigo Corrêa deFonseca, Flávio Guimarães da2014-07-14T18:55:13Z2014-07-14T18:55:13Z2012GOMES, Juliana Assis Silva et al. Immune modulation in primary vaccinia virus zoonotic human infections. Clinical and Developmental Immunology. 2012; vol.2012, pp. 974067.1740-2522https://www.arca.fiocruz.br/handle/icict/795410.1155/2012/974067FAPEMIG , CNPq, National Institute of Science and Technology in VaccinesUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Morfologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFaculdade de Medicina de São José do Rio Preto. Departamento de Doenças Infecciosas e Parasitárias. São José do Rio Preto, SP, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilIn 2010, the WHO celebrated the 30th anniversary of the smallpox eradication. Ironically, infections caused by viruses related to smallpox are being increasingly reported worldwide, including Monkeypox, Cowpox, and Vaccinia virus (VACV). Little is known about the human immunological responses elicited during acute infections caused by orthopoxviruses. We have followed VACV zoonotic outbreaks taking place in Brazil and analyzed cellular immune responses in patients acutely infected by VACV. Results indicated that these patients show a biased immune modulation when compared to noninfected controls. Amounts of B cells are low and less activated in infected patients. Although present, T CD4+ cells are also less activated when compared to noninfected individuals, and so are monocytes/macrophages. Similar results were obtained when Balb/C mice were experimentally infected with a VACV sample isolated during the zoonotic outbreaks. Taking together, the data suggest that zoonotic VACVs modulate specific immune cell compartments during an acute infection in humansengHindawi Publishing CorporationImmune modulation in primary vaccinia virus zoonotic human infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCD4-Positive T-LymphocytesAntigensImmunity, CellularLymphocyte Activationinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALImmune modulation in primary vaccinia virus zoonotic human infections.pdfImmune modulation in primary vaccinia virus zoonotic human infections.pdfapplication/pdf1702515https://www.arca.fiocruz.br/bitstream/icict/7954/1/Immune%20modulation%20in%20primary%20vaccinia%20virus%20zoonotic%20human%20infections.pdfede11f61d3e10b7c1b97a5477f3f12deMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7954/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTImmune modulation in primary vaccinia virus zoonotic human infections.pdf.txtImmune modulation in primary vaccinia virus zoonotic human infections.pdf.txtExtracted texttext/plain51430https://www.arca.fiocruz.br/bitstream/icict/7954/3/Immune%20modulation%20in%20primary%20vaccinia%20virus%20zoonotic%20human%20infections.pdf.txtb70a81675938133a2c601c6fb03e22a3MD53icict/79542018-04-06 11:25:52.862oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T14:25:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Immune modulation in primary vaccinia virus zoonotic human infections |
| title |
Immune modulation in primary vaccinia virus zoonotic human infections |
| spellingShingle |
Immune modulation in primary vaccinia virus zoonotic human infections Gomes, Juliana de Assis Silva CD4-Positive T-Lymphocytes Antigens Immunity, Cellular Lymphocyte Activation |
| title_short |
Immune modulation in primary vaccinia virus zoonotic human infections |
| title_full |
Immune modulation in primary vaccinia virus zoonotic human infections |
| title_fullStr |
Immune modulation in primary vaccinia virus zoonotic human infections |
| title_full_unstemmed |
Immune modulation in primary vaccinia virus zoonotic human infections |
| title_sort |
Immune modulation in primary vaccinia virus zoonotic human infections |
| author |
Gomes, Juliana de Assis Silva |
| author_facet |
Gomes, Juliana de Assis Silva Araújo, Fernanda Fortes de Trindade, Giliane de Souza Quinan, Bárbara Resende Drumond, Betânia Paiva Ferreira, Jaqueline Maria Siqueira Mota, Bruno Eduardo Fernandes Nogueira, Maurício Lacerda Kroon, Erna Geessien Abrahão, Jônatas Santos Oliveira, Rodrigo Corrêa de Fonseca, Flávio Guimarães da |
| author_role |
author |
| author2 |
Araújo, Fernanda Fortes de Trindade, Giliane de Souza Quinan, Bárbara Resende Drumond, Betânia Paiva Ferreira, Jaqueline Maria Siqueira Mota, Bruno Eduardo Fernandes Nogueira, Maurício Lacerda Kroon, Erna Geessien Abrahão, Jônatas Santos Oliveira, Rodrigo Corrêa de Fonseca, Flávio Guimarães da |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gomes, Juliana de Assis Silva Araújo, Fernanda Fortes de Trindade, Giliane de Souza Quinan, Bárbara Resende Drumond, Betânia Paiva Ferreira, Jaqueline Maria Siqueira Mota, Bruno Eduardo Fernandes Nogueira, Maurício Lacerda Kroon, Erna Geessien Abrahão, Jônatas Santos Oliveira, Rodrigo Corrêa de Fonseca, Flávio Guimarães da |
| dc.subject.en.pt_BR.fl_str_mv |
CD4-Positive T-Lymphocytes Antigens Immunity, Cellular Lymphocyte Activation |
| topic |
CD4-Positive T-Lymphocytes Antigens Immunity, Cellular Lymphocyte Activation |
| description |
FAPEMIG , CNPq, National Institute of Science and Technology in Vaccines |
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2012 |
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2012 |
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2014-07-14T18:55:13Z |
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2014-07-14T18:55:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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GOMES, Juliana Assis Silva et al. Immune modulation in primary vaccinia virus zoonotic human infections. Clinical and Developmental Immunology. 2012; vol.2012, pp. 974067. |
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https://www.arca.fiocruz.br/handle/icict/7954 |
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1740-2522 |
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10.1155/2012/974067 |
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GOMES, Juliana Assis Silva et al. Immune modulation in primary vaccinia virus zoonotic human infections. Clinical and Developmental Immunology. 2012; vol.2012, pp. 974067. 1740-2522 10.1155/2012/974067 |
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