Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy

Detalhes bibliográficos
Autor(a) principal: Santana, Alessandra
Data de Publicação: 2009
Outros Autores: Loureiro, Camila, Barbosa Junior, Aryon de Almeida, Arruda, Sérgio Marcos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/12966
Resumo: Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
id CRUZ_5d4e0736d2e6b0612abdb23559734b12
oai_identifier_str oai:www.arca.fiocruz.br:icict/12966
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Santana, AlessandraLoureiro, CamilaBarbosa Junior, Aryon de AlmeidaArruda, Sérgio Marcos2016-03-03T17:01:17Z2016-03-03T17:01:17Z2009SANTANA, A. et al. Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy. International Journal of Morphology, v. 27, n. 1, p. 193-209, 2009.0717-9367https://www.arca.fiocruz.br/handle/icict/12966engSociedad Chilena de AnatomiaMorphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous PleurisyAnálisis Morfológico de la Necrosis Caseosa y su Correlación con Células CD68+ y CD8+ en Biopsias de Pleuritis Tuberculosainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / FAPESB. Fundação de Amparo à Pesquisa do Estado da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia Experimental. Salvador, BA, BrasilEscola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilTuberculosis is the most prevalent infectious disease in the world. Granuloma formation and caseous necrosis are hallmarks of M. tuberculosis infection and they represent the protective and inflammatory reactions in the infected tissues. The molecular mechanisms that mediate granuloma necrosis are still not well understood. Objectives: To immunolocalize and correlate the amounts of CD68+ macrophages and CD8+ lymphocytes to caseous necrosis extension in granulomas of tuberculous pleurisy. Methods: The study is a retrospective analysis of 30 pleural biopsies with histopathological diagnosis of chronic granulomatous pleurisy with caseous necrosis. These biopsies were classified according to necrosis intensity as minimal (N1), moderate (N2) and intense (N3). The number of granulomas was also observed and categorized as G1 (1 to 4 granulomas per section), G2 (5 to 8 granulomas per section), and G3 (more than 8 granulomas per section). Results: The means of CD68+ cells counts per mm2 in N1, N2 and N3 categories of necrosis were 1,287 ± 254, 1086 ± 181 and 930 ± 115 respectively. The means for CD8+ cells were 483.7 ± 396, 366.3 ± 43 and 558 ± 53 cells per mm2 in N1, N2 and N3 respectively. Conclusions: There were no significant statistical correlations between necrosis extension and cell counts. In analyzed biopsies, the number of CD68+ cells was significantly higher than the number of CD8+ cells.Tuberculous pleurisyCD68+ macrophagesT CD8+ cellsCaseous necrosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/12966/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSantana, A Morphological analyses....pdfSantana, A Morphological analyses....pdfapplication/pdf1507981https://www.arca.fiocruz.br/bitstream/icict/12966/2/Santana%2c%20A%20Morphological%20analyses....pdf8d660bd3406e1eeec6c3c7e1b392b990MD52TEXTSantana, A Morphological analyses....pdf.txtSantana, A Morphological analyses....pdf.txtExtracted texttext/plain29412https://www.arca.fiocruz.br/bitstream/icict/12966/3/Santana%2c%20A%20Morphological%20analyses....pdf.txt2ca3d936323662828ee308d4e8ec4cf1MD53icict/129662023-03-15 14:34:02.172oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
dc.title.alternative.pt_BR.fl_str_mv Análisis Morfológico de la Necrosis Caseosa y su Correlación con Células CD68+ y CD8+ en Biopsias de Pleuritis Tuberculosa
title Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
spellingShingle Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
Santana, Alessandra
Tuberculous pleurisy
CD68+ macrophages
T CD8+ cells
Caseous necrosis
title_short Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_full Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_fullStr Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_full_unstemmed Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
title_sort Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy
author Santana, Alessandra
author_facet Santana, Alessandra
Loureiro, Camila
Barbosa Junior, Aryon de Almeida
Arruda, Sérgio Marcos
author_role author
author2 Loureiro, Camila
Barbosa Junior, Aryon de Almeida
Arruda, Sérgio Marcos
author2_role author
author
author
dc.contributor.author.fl_str_mv Santana, Alessandra
Loureiro, Camila
Barbosa Junior, Aryon de Almeida
Arruda, Sérgio Marcos
dc.subject.en.pt_BR.fl_str_mv Tuberculous pleurisy
CD68+ macrophages
T CD8+ cells
Caseous necrosis
topic Tuberculous pleurisy
CD68+ macrophages
T CD8+ cells
Caseous necrosis
description Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2016-03-03T17:01:17Z
dc.date.available.fl_str_mv 2016-03-03T17:01:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SANTANA, A. et al. Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy. International Journal of Morphology, v. 27, n. 1, p. 193-209, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/12966
dc.identifier.issn.none.fl_str_mv 0717-9367
identifier_str_mv SANTANA, A. et al. Morphological Analyses of Caseous Necrosis Correlated to CD68+ and CD8+ Cells in Biopsies of Tuberculous Pleurisy. International Journal of Morphology, v. 27, n. 1, p. 193-209, 2009.
0717-9367
url https://www.arca.fiocruz.br/handle/icict/12966
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedad Chilena de Anatomia
publisher.none.fl_str_mv Sociedad Chilena de Anatomia
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/12966/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/12966/2/Santana%2c%20A%20Morphological%20analyses....pdf
https://www.arca.fiocruz.br/bitstream/icict/12966/3/Santana%2c%20A%20Morphological%20analyses....pdf.txt
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
8d660bd3406e1eeec6c3c7e1b392b990
2ca3d936323662828ee308d4e8ec4cf1
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009109155315712

Registros relacionados