The multiple functions of the endocannabinoid system: a focus on the regulation of food intake

Detalhes bibliográficos
Autor(a) principal: Tibiriçá, Eduardo
Data de Publicação: 2010
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30437
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação cardiovascular. Rio de Janeiro, RJ, Brasil.
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spelling Tibiriçá, Eduardo2018-12-08T13:32:06Z2018-12-08T13:32:06Z2010TIBIRIÇÁ, Eduardo. The multiple functions of the endocannabinoid system: a focus on the regulation of food intake. Diabetology & Metabolic Syndrome, v.2, n.5, 6p, 2010.1758-5996https://www.arca.fiocruz.br/handle/icict/3043710.1186/1758-5996-2-5engBioMed Centralsistema endocanabinoidemúltiplas funçõesregulação da ingestão de alimentosfocoendocannabinoid systemmultiple functionsregulation of food intakefocusThe multiple functions of the endocannabinoid system: a focus on the regulation of food intakeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação cardiovascular. Rio de Janeiro, RJ, Brasil.Background: Cannabis sativa (also known as marijuana) has been cultivated by man for more than 5,000 years. However, there was a rise in its use in the 20th century for recreational, religious or spiritual, and medicinal purposes. The main psychoactive constituent of cannabis, whose structure was identified in the 1960’s, is Δ9tetrahydrocannabinol. On the other hand, the discovery of cannabinoid receptors and their endogenous agonists took place only very recently. In fact, the first cannabinoid receptor (CB1) was cloned in 1990, followed 3 years later by the characterization of a second cannabinoid receptor (CB2). Since the 19th century, the use of cannabis has been reported to stimulate appetite and increase the consumption of sweet and tasty food, sometimes resulting in significant weight gain. The recent description of the endocannabinoid system, not only in the central nervous system but also in peripheral tissues, points to its involvement in the regulation of appetite, food intake and energy metabolism. Consequently, the pharmacological modulation of the over-activity of this system could be useful in the treatment of the metabolic syndrome. Conclusions: The endocannabinoid system has important physiological functions not only in the central nervous system but also in peripheral tissues. The activation of central CB1 receptors, particularly in hypothalamic nuclei and in the limbic system, is involved in the regulation of feeding behavior, and especially in the control of the intake of palatable food. 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dc.title.pt_BR.fl_str_mv The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
title The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
spellingShingle The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
Tibiriçá, Eduardo
sistema endocanabinoide
múltiplas funções
regulação da ingestão de alimentos
foco
endocannabinoid system
multiple functions
regulation of food intake
focus
title_short The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
title_full The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
title_fullStr The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
title_full_unstemmed The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
title_sort The multiple functions of the endocannabinoid system: a focus on the regulation of food intake
author Tibiriçá, Eduardo
author_facet Tibiriçá, Eduardo
author_role author
dc.contributor.author.fl_str_mv Tibiriçá, Eduardo
dc.subject.other.pt_BR.fl_str_mv sistema endocanabinoide
múltiplas funções
regulação da ingestão de alimentos
foco
topic sistema endocanabinoide
múltiplas funções
regulação da ingestão de alimentos
foco
endocannabinoid system
multiple functions
regulation of food intake
focus
dc.subject.en.pt_BR.fl_str_mv endocannabinoid system
multiple functions
regulation of food intake
focus
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação cardiovascular. Rio de Janeiro, RJ, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-12-08T13:32:06Z
dc.date.available.fl_str_mv 2018-12-08T13:32:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TIBIRIÇÁ, Eduardo. The multiple functions of the endocannabinoid system: a focus on the regulation of food intake. Diabetology & Metabolic Syndrome, v.2, n.5, 6p, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30437
dc.identifier.issn.pt_BR.fl_str_mv 1758-5996
dc.identifier.doi.none.fl_str_mv 10.1186/1758-5996-2-5
identifier_str_mv TIBIRIÇÁ, Eduardo. The multiple functions of the endocannabinoid system: a focus on the regulation of food intake. Diabetology & Metabolic Syndrome, v.2, n.5, 6p, 2010.
1758-5996
10.1186/1758-5996-2-5
url https://www.arca.fiocruz.br/handle/icict/30437
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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