Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil

Detalhes bibliográficos
Autor(a) principal: Ranzani, Otavio T.
Data de Publicação: 2022
Outros Autores: Hitchings, Matt D. T., Melo, Rosana Leite de, França, Giovanny V. A. de, Fernandes, Cássia de Fátima R., Lind, Margaret L., Torres, Mario Sergio Scaramuzzini, Tsuha, Daniel Henrique, David, Leticia C. S., Said, Rodrigo F. C., Almiron, Maria, Oliveira, Roberto D. de, Cummings, Derek A. T., Dean, Natalie E., Andrews, Jason R., Ko, Albert I., Croda, Julio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56134
Resumo: These authors contributed equally: Derek A. T. Cummings, Natalie E Dean, Jason R. Andrews, Albert I. Ko, Julio Croda.
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spelling Ranzani, Otavio T.Hitchings, Matt D. T.Melo, Rosana Leite deFrança, Giovanny V. A. deFernandes, Cássia de Fátima R.Lind, Margaret L.Torres, Mario Sergio ScaramuzziniTsuha, Daniel HenriqueDavid, Leticia C. S.Said, Rodrigo F. C.Almiron, MariaOliveira, Roberto D. deCummings, Derek A. T.Dean, Natalie E.Andrews, Jason R.Ko, Albert I.Croda, Julio2022-12-21T17:12:03Z2022-12-21T17:12:03Z2022RANZANI, Otavio T. et al. Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against the Omicron in Brazil. Nature Communications, p. 1-10, 2022.https://www.arca.fiocruz.br/handle/icict/5613410.1038/s41467-022-33169-0These authors contributed equally: Derek A. T. Cummings, Natalie E Dean, Jason R. Andrews, Albert I. Ko, Julio Croda.We thank the Pan American Health Organization for its support. No external funding was provided for this study. OTR is funded by a Sara Borrell fellowship (CD19/00110) from the Instituto de Salud Carlos III. OTR acknowledges support from the Spanish Ministry of Science and Innovation through the Centro de Excelencia Severo Ochoa 2019-2023 programme (CEX2018-000806-S) and from the Generalitat de Catalunya through the Centres de Recerca de Catalunya (CERCA) programme. DATC and MDH report a contract from Merck (to the University of Florida) for research unrelated to this manuscript. These institutions had no role in the study design, data collection, data analysis, data interpretation, or writing of the report.Universitat Pompeu Fabra. Barcelona Institute for Global Health. ISGlobal. Barcelona, Spain / Faculdade de Medicina. Hospital das Clínicas. Heart Institute. Pulmonary Division. São Paulo, SP, Brazil / CIBER Epidemiología y Salud Pública (CIBERESP). Madrid, Spain.University of Florida. College of Public Health & Health Professions. Department of Biostatistics. Gainesville, FL, USA.Ministério da Saúde. Secretaria Extraordinária de Enfrentamento à Covid-19. Brasília, DF, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brazil.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA.Secretary of Manaus. Municipal Health. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brazil.Pan American Health Organization, Brasilia, DF, Brazil.Pan American Health Organization, Brasilia, DF, Brazil.Pan American Health Organization, Brasilia, DF, Brazil.State University of Mato Grosso do Sul, Dourados, MS, Brazil.University of Florida. Department of Biology. Gainesville, FL, USA / University of Florida. Emerging Pathogens Institute, Gainesville, FL, USA.Emory University. Rollins School of Public Health. Department of Biostatistics & Bioinformatics, Atlanta, GA, USA.Stanford University. Division of Infectious Diseases and Geographic Medicine. Stanford, CA, USA.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, CT, USA / Fundação Oswaldo Cruz. Fiocruz Mato Grosso do Sul. Campo Grande, MS, Brazil / Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil.The effectiveness of inactivated vaccines (VE) against symptomatic and severe COVID-19 caused by omicron is unknown. We conducted a nationwide, testnegative, case-control study to estimate VE for homologous and heterologous (BNT162b2) booster doses in adults who received two doses of CoronaVac in Brazil in the Omicron context. Analyzing 1,386,544 matched-pairs, VE against symptomatic disease was 8.6% (95% CI, 5.6–11.5) and 56.8% (95% CI, 56.3–57.3) in the period 8–59 days after receiving a homologous and heterologous booster, respectively. During the same interval, VE against severe Covid-19 was 73.6% (95% CI, 63.9–80.7) and 86.0% (95% CI, 84.5–87.4) after receiving a homologous and heterologous booster, respectively. Waning against severe Covid-19 after 120 days was only observed after a homologous booster. Heterologous booster might be preferable to individuals with completed primary series inactivated vaccine.engNatureCOVID-19VacinasCoronaVacVacina BNT162Estudos de Casos e ControlesImunização SecundáriaCOVID-19VaccinesCoronaVacBNT162b2Case-control studyBoosterCOVID-19VacinasCoronaVacVacina BNT162Estudos de Casos e ControlesImunização SecundáriaEffectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALRanzani_Otavio_etal_FIOCRUZ_MS_2022_COVID-19.pdfRanzani_Otavio_etal_FIOCRUZ_MS_2022_COVID-19.pdfapplication/pdf833989https://www.arca.fiocruz.br/bitstream/icict/56134/3/Ranzani_Otavio_etal_FIOCRUZ_MS_2022_COVID-19.pdf1ef70112f981f442fc42e6e80ff16012MD53LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
title Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
spellingShingle Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
Ranzani, Otavio T.
COVID-19
Vacinas
CoronaVac
Vacina BNT162
Estudos de Casos e Controles
Imunização Secundária
COVID-19
Vaccines
CoronaVac
BNT162b2
Case-control study
Booster
COVID-19
Vacinas
CoronaVac
Vacina BNT162
Estudos de Casos e Controles
Imunização Secundária
title_short Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
title_full Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
title_fullStr Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
title_full_unstemmed Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
title_sort Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil
author Ranzani, Otavio T.
author_facet Ranzani, Otavio T.
Hitchings, Matt D. T.
Melo, Rosana Leite de
França, Giovanny V. A. de
Fernandes, Cássia de Fátima R.
Lind, Margaret L.
Torres, Mario Sergio Scaramuzzini
Tsuha, Daniel Henrique
David, Leticia C. S.
Said, Rodrigo F. C.
Almiron, Maria
Oliveira, Roberto D. de
Cummings, Derek A. T.
Dean, Natalie E.
Andrews, Jason R.
Ko, Albert I.
Croda, Julio
author_role author
author2 Hitchings, Matt D. T.
Melo, Rosana Leite de
França, Giovanny V. A. de
Fernandes, Cássia de Fátima R.
Lind, Margaret L.
Torres, Mario Sergio Scaramuzzini
Tsuha, Daniel Henrique
David, Leticia C. S.
Said, Rodrigo F. C.
Almiron, Maria
Oliveira, Roberto D. de
Cummings, Derek A. T.
Dean, Natalie E.
Andrews, Jason R.
Ko, Albert I.
Croda, Julio
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ranzani, Otavio T.
Hitchings, Matt D. T.
Melo, Rosana Leite de
França, Giovanny V. A. de
Fernandes, Cássia de Fátima R.
Lind, Margaret L.
Torres, Mario Sergio Scaramuzzini
Tsuha, Daniel Henrique
David, Leticia C. S.
Said, Rodrigo F. C.
Almiron, Maria
Oliveira, Roberto D. de
Cummings, Derek A. T.
Dean, Natalie E.
Andrews, Jason R.
Ko, Albert I.
Croda, Julio
dc.subject.other.en_US.fl_str_mv COVID-19
Vacinas
CoronaVac
Vacina BNT162
Estudos de Casos e Controles
Imunização Secundária
topic COVID-19
Vacinas
CoronaVac
Vacina BNT162
Estudos de Casos e Controles
Imunização Secundária
COVID-19
Vaccines
CoronaVac
BNT162b2
Case-control study
Booster
COVID-19
Vacinas
CoronaVac
Vacina BNT162
Estudos de Casos e Controles
Imunização Secundária
dc.subject.en.en_US.fl_str_mv COVID-19
Vaccines
CoronaVac
BNT162b2
Case-control study
Booster
dc.subject.decs.en_US.fl_str_mv COVID-19
Vacinas
CoronaVac
Vacina BNT162
Estudos de Casos e Controles
Imunização Secundária
description These authors contributed equally: Derek A. T. Cummings, Natalie E Dean, Jason R. Andrews, Albert I. Ko, Julio Croda.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-12-21T17:12:03Z
dc.date.available.fl_str_mv 2022-12-21T17:12:03Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv RANZANI, Otavio T. et al. Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against the Omicron in Brazil. Nature Communications, p. 1-10, 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56134
dc.identifier.doi.none.fl_str_mv 10.1038/s41467-022-33169-0
identifier_str_mv RANZANI, Otavio T. et al. Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against the Omicron in Brazil. Nature Communications, p. 1-10, 2022.
10.1038/s41467-022-33169-0
url https://www.arca.fiocruz.br/handle/icict/56134
dc.language.iso.fl_str_mv eng
language eng
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dc.publisher.none.fl_str_mv Nature
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bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56134/3/Ranzani_Otavio_etal_FIOCRUZ_MS_2022_COVID-19.pdf
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