Histopathological and immunological characteristics of placentas infected with chikungunya virus

Detalhes bibliográficos
Autor(a) principal: Salomão, Natália
Data de Publicação: 2022
Outros Autores: Rabelo, Kíssila, Avvad-Portari, Elyzabeth, Oliveira, Carlos Basílio de, Oliveira, Rodrigo Basílio de, Ferreira, Fátima, Ferreira, Luiz, Souza, Thiara Manuele de, Nunes, Priscila, Lima, Monique, Sales, Anna Paula, Fernandes, Regina, Souza, Luiz José de, Dias, Laura, Brasil, Patrícia, Santos, Flavia dos, Paes, Marciano
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/56432
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
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spelling Salomão, NatáliaRabelo, KíssilaAvvad-Portari, ElyzabethOliveira, Carlos Basílio deOliveira, Rodrigo Basílio deFerreira, FátimaFerreira, LuizSouza, Thiara Manuele deNunes, PriscilaLima, MoniqueSales, Anna PaulaFernandes, ReginaSouza, Luiz José deDias, LauraBrasil, PatríciaSantos, Flavia dosPaes, Marciano2023-01-10T18:45:17Z2023-01-10T18:45:17Z2022SALOMÃO, Natália et al. Histopathological and immunological characteristics of placentas infected with chikungunya virus. Frontiers in Microbiology, v. 13, 1055536, p. 1-11, Nov. 2022.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/5643210.3389/fmicb.2022.1055536engFrontiers MediaPlacentaChikungunyaHistopatologiaImuno-histoquímicaCitocinasPlacentaChikungunyaHistopathologyImmunohistochemistryCytokinesHistopathological and immunological characteristics of placentas infected with chikungunya virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Laboratório de Ultraestrutura e Biologia Tecidual. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto da Mulher e da Criança Fernandes Figueira. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Neonatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Instituto Butantan. Laboratório Estratégico de Diagnóstico Molecular. São Paulo, SP, Brasil.Centro de Referência de Doenças Imuno-infecciosas. Campos dos Goytacazes, RJ, Brasil.Faculdade de Medicina de Campos, Campos dos Goytacazes, RJ, Brasil / Universidade Estadual do Norte Fluminense. Laboratório de Biotecnologia. Campos dos Goytacazes, RJ, Brasil.Centro de Referência de Doenças Imuno-infecciosas. Campos dos Goytacazes, RJ, Brasil / Faculdade de Medicina de Campos, Campos dos Goytacazes. RJ, Brasil.Hospital Geral Dr. Beda. CEPLIN – Uti Neonatal Nicola Albano. Campos dos Goytacazes, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, BrasilAlthough vertical transmission of CHIKV has been reported, little is known about the role of placenta in the transmission of this virus and the effects of infection on the maternal-fetal interface. In this work we investigated five placentas from pregnant women who became infected during the gestational period. Four formalin-fixed paraffin-embedded samples of placenta (cases 1–4) were positive for CHIKV by RT-PCR. One (case 5) had no positive test of placenta, but had positive RT-PCR for CHIKV in the serum of the mother and the baby, confirming vertical transmission. The placentas were analyzed regarding histopathological and immunological aspects. The main histopathological changes were: deciduitis, villous edema, deposits, villous necrosis, dystrophic calcification, thrombosis and stem vessel obliteration. In infected placentas we noted increase of cells (CD8+ and CD163+) and pro- (IFN-γ and TNF-α) and anti-inflammatory (TGF-β and IL-10) cytokines compared to control placentas. Moreover, CHIKV antigen was detected in decidual cell, trophoblastic cells, stroma villi, Hofbauer cells, and endothelial cells. In conclusion, CHIKV infection seems to disrupt placental homeostasis leading to histopathological alterations in addition to increase in cellularity and cytokines overproduction, evidencing an altered and harmful environment to the pregnant woman and fetus.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56432/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALNataliaSalomao_FlaviaSantos_et_IOC_2022.pdfNataliaSalomao_FlaviaSantos_et_IOC_2022.pdfapplication/pdf3063354https://www.arca.fiocruz.br/bitstream/icict/56432/2/NataliaSalomao_FlaviaSantos_et_IOC_2022.pdfaf185c58506ed885647b1e68216c1071MD52icict/564322023-09-04 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dc.title.en_US.fl_str_mv Histopathological and immunological characteristics of placentas infected with chikungunya virus
title Histopathological and immunological characteristics of placentas infected with chikungunya virus
spellingShingle Histopathological and immunological characteristics of placentas infected with chikungunya virus
Salomão, Natália
Placenta
Chikungunya
Histopatologia
Imuno-histoquímica
Citocinas
Placenta
Chikungunya
Histopathology
Immunohistochemistry
Cytokines
title_short Histopathological and immunological characteristics of placentas infected with chikungunya virus
title_full Histopathological and immunological characteristics of placentas infected with chikungunya virus
title_fullStr Histopathological and immunological characteristics of placentas infected with chikungunya virus
title_full_unstemmed Histopathological and immunological characteristics of placentas infected with chikungunya virus
title_sort Histopathological and immunological characteristics of placentas infected with chikungunya virus
author Salomão, Natália
author_facet Salomão, Natália
Rabelo, Kíssila
Avvad-Portari, Elyzabeth
Oliveira, Carlos Basílio de
Oliveira, Rodrigo Basílio de
Ferreira, Fátima
Ferreira, Luiz
Souza, Thiara Manuele de
Nunes, Priscila
Lima, Monique
Sales, Anna Paula
Fernandes, Regina
Souza, Luiz José de
Dias, Laura
Brasil, Patrícia
Santos, Flavia dos
Paes, Marciano
author_role author
author2 Rabelo, Kíssila
Avvad-Portari, Elyzabeth
Oliveira, Carlos Basílio de
Oliveira, Rodrigo Basílio de
Ferreira, Fátima
Ferreira, Luiz
Souza, Thiara Manuele de
Nunes, Priscila
Lima, Monique
Sales, Anna Paula
Fernandes, Regina
Souza, Luiz José de
Dias, Laura
Brasil, Patrícia
Santos, Flavia dos
Paes, Marciano
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salomão, Natália
Rabelo, Kíssila
Avvad-Portari, Elyzabeth
Oliveira, Carlos Basílio de
Oliveira, Rodrigo Basílio de
Ferreira, Fátima
Ferreira, Luiz
Souza, Thiara Manuele de
Nunes, Priscila
Lima, Monique
Sales, Anna Paula
Fernandes, Regina
Souza, Luiz José de
Dias, Laura
Brasil, Patrícia
Santos, Flavia dos
Paes, Marciano
dc.subject.other.en_US.fl_str_mv Placenta
Chikungunya
Histopatologia
Imuno-histoquímica
Citocinas
topic Placenta
Chikungunya
Histopatologia
Imuno-histoquímica
Citocinas
Placenta
Chikungunya
Histopathology
Immunohistochemistry
Cytokines
dc.subject.en.en_US.fl_str_mv Placenta
Chikungunya
Histopathology
Immunohistochemistry
Cytokines
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório Interdisciplinar de Pesquisas Médicas. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Viral. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.issued.fl_str_mv 2022
dc.date.accessioned.fl_str_mv 2023-01-10T18:45:17Z
dc.date.available.fl_str_mv 2023-01-10T18:45:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SALOMÃO, Natália et al. Histopathological and immunological characteristics of placentas infected with chikungunya virus. Frontiers in Microbiology, v. 13, 1055536, p. 1-11, Nov. 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/56432
dc.identifier.issn.en_US.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2022.1055536
identifier_str_mv SALOMÃO, Natália et al. Histopathological and immunological characteristics of placentas infected with chikungunya virus. Frontiers in Microbiology, v. 13, 1055536, p. 1-11, Nov. 2022.
1664-302X
10.3389/fmicb.2022.1055536
url https://www.arca.fiocruz.br/handle/icict/56432
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/56432/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/56432/2/NataliaSalomao_FlaviaSantos_et_IOC_2022.pdf
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