Extracellular Vesicles in Trypanosomatids: Host Cell Communication

Detalhes bibliográficos
Autor(a) principal: Torrecilhas, Ana Claudia
Data de Publicação: 2020
Outros Autores: Soares, Rodrigo Pedro, Schenkman, Sergio, Fernández-Prada, Christopher, Olivier, Martin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/59422
Resumo: Federal University of Sao Paulo. Departamento de Ciências Farmacêuticas. Diadema, SP, Brazil.
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spelling Torrecilhas, Ana ClaudiaSoares, Rodrigo PedroSchenkman, SergioFernández-Prada, ChristopherOlivier, Martin2023-07-05T13:56:08Z2023-07-05T13:56:08Z2020TORRECILHAS, Ana Claudia et al. Extracellular Vesicles in Trypanosomatids: Host Cell Communication. Frontiers in Cellular and Infection Microbiology, v. 14, p. 1-16, Dec. 2020.2235-2988https://www.arca.fiocruz.br/handle/icict/5942210.1016/j.vetpar.2013.03.017engFrontiers MediaExtracellular Vesicles in Trypanosomatids: Host Cell Communicationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Sao Paulo. Departamento de Ciências Farmacêuticas. Diadema, SP, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brazil.Université de Montréal. Faculty of Veterinary Medicin. St-Hyacinthe, QC, Canada.McGill University. The Research Institute of the McGill University Health Centre. Montréal, QC, Canada.Trypanosoma cruzi, Trypanosoma brucei and Leishmania (Trypanosomatidae: Kinetoplastida) are parasitic protozoan causing Chagas disease, African Trypanosomiasis and Leishmaniases worldwide. They are vector borne diseases transmitted by triatomine bugs, Tsetse fly, and sand flies, respectively. Those diseases cause enormous economic losses and morbidity affecting not only rural and poverty areas but are also spreading to urban areas. During the parasite-host interaction, those organisms release extracellular vesicles (EVs) that are crucial for the immunomodulatory events triggered by the parasites. EVs are involved in cell-cell communication and can act as important pro-inflammatory mediators. Therefore, interface between EVs and host immune responses are crucial for the immunopathological events that those diseases exhibit. Additionally, EVs from these organisms have a role in the invertebrate hosts digestive tracts prior to parasite transmission. This review summarizes the available data on how EVs from those medically important trypanosomatids affect their interaction with vertebrate and invertebrate hosts.LeishmaniaTrypanosoma bruceiTrypanosoma cruziExtracellular vesiclesInflammationInnate immunityInsect vectorSkin pathologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Ana_Torrecilhas_etal_IRR_2020.pdfve_Ana_Torrecilhas_etal_IRR_2020.pdfapplication/pdf823674https://www.arca.fiocruz.br/bitstream/icict/59422/2/ve_Ana_Torrecilhas_etal_IRR_2020.pdf504a32b47a90a777b574fe9fdd6bf2adMD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59422/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/594222023-07-05 23:58:11.601oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-06T02:58:11Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Extracellular Vesicles in Trypanosomatids: Host Cell Communication
title Extracellular Vesicles in Trypanosomatids: Host Cell Communication
spellingShingle Extracellular Vesicles in Trypanosomatids: Host Cell Communication
Torrecilhas, Ana Claudia
Leishmania
Trypanosoma brucei
Trypanosoma cruzi
Extracellular vesicles
Inflammation
Innate immunity
Insect vector
Skin pathology
title_short Extracellular Vesicles in Trypanosomatids: Host Cell Communication
title_full Extracellular Vesicles in Trypanosomatids: Host Cell Communication
title_fullStr Extracellular Vesicles in Trypanosomatids: Host Cell Communication
title_full_unstemmed Extracellular Vesicles in Trypanosomatids: Host Cell Communication
title_sort Extracellular Vesicles in Trypanosomatids: Host Cell Communication
author Torrecilhas, Ana Claudia
author_facet Torrecilhas, Ana Claudia
Soares, Rodrigo Pedro
Schenkman, Sergio
Fernández-Prada, Christopher
Olivier, Martin
author_role author
author2 Soares, Rodrigo Pedro
Schenkman, Sergio
Fernández-Prada, Christopher
Olivier, Martin
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Torrecilhas, Ana Claudia
Soares, Rodrigo Pedro
Schenkman, Sergio
Fernández-Prada, Christopher
Olivier, Martin
dc.subject.en.none.fl_str_mv Leishmania
Trypanosoma brucei
Trypanosoma cruzi
Extracellular vesicles
Inflammation
Innate immunity
Insect vector
Skin pathology
topic Leishmania
Trypanosoma brucei
Trypanosoma cruzi
Extracellular vesicles
Inflammation
Innate immunity
Insect vector
Skin pathology
description Federal University of Sao Paulo. Departamento de Ciências Farmacêuticas. Diadema, SP, Brazil.
publishDate 2020
dc.date.issued.fl_str_mv 2020
dc.date.accessioned.fl_str_mv 2023-07-05T13:56:08Z
dc.date.available.fl_str_mv 2023-07-05T13:56:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TORRECILHAS, Ana Claudia et al. Extracellular Vesicles in Trypanosomatids: Host Cell Communication. Frontiers in Cellular and Infection Microbiology, v. 14, p. 1-16, Dec. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/59422
dc.identifier.issn.none.fl_str_mv 2235-2988
dc.identifier.doi.pt_BR.fl_str_mv 10.1016/j.vetpar.2013.03.017
identifier_str_mv TORRECILHAS, Ana Claudia et al. Extracellular Vesicles in Trypanosomatids: Host Cell Communication. Frontiers in Cellular and Infection Microbiology, v. 14, p. 1-16, Dec. 2020.
2235-2988
10.1016/j.vetpar.2013.03.017
url https://www.arca.fiocruz.br/handle/icict/59422
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/59422/2/ve_Ana_Torrecilhas_etal_IRR_2020.pdf
https://www.arca.fiocruz.br/bitstream/icict/59422/1/license.txt
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