Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas

Detalhes bibliográficos
Autor(a) principal: Spitz, Natália
Data de Publicação: 2019
Outros Autores: Mello, Francisco C. A., Moreira, Aline S., Gusatti, Carolina S., Martins, Regina M. B., Gomes, Selma A., Bello, Gonzalo, Araujo, Natalia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/40799
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
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spelling Spitz, NatáliaMello, Francisco C. A.Moreira, Aline S.Gusatti, Carolina S.Martins, Regina M. B.Gomes, Selma A.Bello, GonzaloAraujo, Natalia M.2020-04-16T13:38:17Z2020-04-16T13:38:17Z2019SPITZ, Natália et al. Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas. Plos One, v. 14, n. 7, e0220342, 20p, July 2019.1932-6203https://www.arca.fiocruz.br/handle/icict/4079910.1371/journal.pone.0220342engPublic Library of ScienceVírus da Hepatite BGenótipo DAméricasDinâmica espacial e temporalHepatitis B virusGenotype DAmericasSpatial and temporal dynamicsReconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil.Fundação Estadual de Produção e Pesquisa Médica. Centro de Desenvolvimento Científico e Tecnológico. Porto Alegre, RS, Brasil.Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.Hepatitis B virus (HBV) genotype D (HBV/D) is globally widespread, and ten subgenotypes (D1 to D10) showing distinct geographic distributions have been described to date. The evolutionary history of HBV/D and its subgenotypes, for which few complete genome sequences are available, in the Americas is not well understood. The main objective of the current study was to determine the full-length genomic sequences of HBV/D isolates from Brazil and frequency, origin and spread of HBV/D subgenotypes in the Americas. Complete HBV/D genomes isolated from 39 Brazilian patients infected with subgenotypes D1 (n = 1), D2 (n = 10), D3 (n = 27), and D4 (n = 1) were sequenced and analyzed together with reference sequences using the Bayesian coalescent and phylogeographic framework. A search for HBV/D sequences available in GenBank revealed 209 complete and 926 partial genomes from American countries (Argentina, Brazil, Canada, Chile, Colombia, Cuba, Haiti, Martinique, Mexico, USA and Venezuela), with the major circulating subgenotypes identified as D1 (26%), D2 (17%), D3 (36%), D4 (21%), and D7 (1%) within the continent. The detailed evolutionary history of HBV/D in the Americas was investigated by using different evolutionary time scales. Spatiotemporal reconstruction analyses using short-term substitution rates suggested times of the most recent common ancestor for the American HBV/D subgenotypes coincident with mass migratory movements to Americas during the 19th and 20th centuries. In particular, significant linkages between Argentina and Syria (D1), Brazil and Central/Eastern Europe (D2), USA and India (D2), and Brazil and Southern Europe (D3) were estimated, consistent with historical and epidemiological data.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/40799/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGonzaloBello_NataliaSpitz_etal_IOC_2019.pdfGonzaloBello_NataliaSpitz_etal_IOC_2019.pdfapplication/pdf2766832https://www.arca.fiocruz.br/bitstream/icict/40799/2/GonzaloBello_NataliaSpitz_etal_IOC_2019.pdf1c275d915f6d662638f152c808227d17MD52TEXTGonzaloBello_NataliaSpitz_etal_IOC_2019.pdf.txtGonzaloBello_NataliaSpitz_etal_IOC_2019.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
title Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
spellingShingle Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
Spitz, Natália
Vírus da Hepatite B
Genótipo D
Américas
Dinâmica espacial e temporal
Hepatitis B virus
Genotype D
Americas
Spatial and temporal dynamics
title_short Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
title_full Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
title_fullStr Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
title_full_unstemmed Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
title_sort Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas
author Spitz, Natália
author_facet Spitz, Natália
Mello, Francisco C. A.
Moreira, Aline S.
Gusatti, Carolina S.
Martins, Regina M. B.
Gomes, Selma A.
Bello, Gonzalo
Araujo, Natalia M.
author_role author
author2 Mello, Francisco C. A.
Moreira, Aline S.
Gusatti, Carolina S.
Martins, Regina M. B.
Gomes, Selma A.
Bello, Gonzalo
Araujo, Natalia M.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Spitz, Natália
Mello, Francisco C. A.
Moreira, Aline S.
Gusatti, Carolina S.
Martins, Regina M. B.
Gomes, Selma A.
Bello, Gonzalo
Araujo, Natalia M.
dc.subject.other.pt_BR.fl_str_mv Vírus da Hepatite B
Genótipo D
Américas
Dinâmica espacial e temporal
topic Vírus da Hepatite B
Genótipo D
Américas
Dinâmica espacial e temporal
Hepatitis B virus
Genotype D
Americas
Spatial and temporal dynamics
dc.subject.en.pt_BR.fl_str_mv Hepatitis B virus
Genotype D
Americas
Spatial and temporal dynamics
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2020-04-16T13:38:17Z
dc.date.available.fl_str_mv 2020-04-16T13:38:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SPITZ, Natália et al. Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas. Plos One, v. 14, n. 7, e0220342, 20p, July 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/40799
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0220342
identifier_str_mv SPITZ, Natália et al. Reconstruction of the spatial and temporal dynamics of hepatitis B virus genotype D in the Americas. Plos One, v. 14, n. 7, e0220342, 20p, July 2019.
1932-6203
10.1371/journal.pone.0220342
url https://www.arca.fiocruz.br/handle/icict/40799
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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