Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features

Detalhes bibliográficos
Autor(a) principal: Ferreira, Paulo Michel Pinheiro
Data de Publicação: 2021
Outros Autores: Ferreira, José Roberto de Oliveira, Sousa, Rayran Walter Ramos de, Bezerra, Daniel Pereira, Militão, Gardenia Carmen Gadelha
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49085
Resumo: “Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnol´ogico” (CNPq) for their personal scholarships (303247/2019-3 and 313350/2018-3, respectively).
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spelling Ferreira, Paulo Michel PinheiroFerreira, José Roberto de OliveiraSousa, Rayran Walter Ramos deBezerra, Daniel PereiraMilitão, Gardenia Carmen Gadelha2021-09-15T19:02:02Z2021-09-15T19:02:02Z2021FERREIRA, Paulo Michel Pinheiro et al. Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features. Journal of Oncology, 2021.1687-8450https://www.arca.fiocruz.br/handle/icict/49085/10.1155/2021/3569349“Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnol´ogico” (CNPq) for their personal scholarships (303247/2019-3 and 313350/2018-3, respectively).Federal University of Piauí. Laboratory of Experimental Cancerology. Department of Biophysics and Physiology. Teresina, PI, Brazil.State University of Health Sciences of Alagoas. Center for Integrative Sciences. Maceió, AL, Brazil.Federal University of Piauí. Laboratory of Experimental Cancerology. Department of Biophysics and Physiology. Teresina, PI, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Federal University of Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.'e indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we conducted a review on the antitumor mechanisms of aminoquinolines, focusing on the responses and differences of tumor histological tissues and toxicity related to pharmacokinetics. 'is well-defined analysis shows similar mechanistic forms triggered by aminoquinolines in different histological tumor tissues and under coexposure conditions, although different pharmacological potencies also occur. 'ese molecules are lysosomotropic amines that increase the antiproliferative action of chemotherapeutic agents, mainly by cell cycle arrest, histone acetylation, physiological changes in tyrosine kinase metabolism, inhibition of PI3K/Akt/mTOR pathways, cyclin D1, E2F1, angiogenesis, ribosome biogenesis, triggering of ATM-ATR/p53/p21 signaling, apoptosis, and presentation of tumor peptides. 'eir chemo/radiotherapy sensitization effects may be an adjuvant option against solid tumors, since 4-aminoquinolines induce lysosomal-mediated programmed cytotoxicity of cancer cells and accumulation of key markers, predominantly, LAMP1, p62/SQSTM1, LC3 members, GAPDH, beclin-1/Atg6, α-synuclein, and granules of lipofuscin. Adverse effects are dose-dependent, though most common with chloroquine, hydroxychloroquine, amodiaquine, and other aminoquinolines are gastrointestinal changes, blurred vision ventricular arrhythmias, cardiac arrest, QTc prolongation, severe hypoglycemia with loss of consciousness, and retinopathy, and they are more common with chloroquine than with hydroxychloroquine and amodiaquine due to pharmacokinetic features. Additionally, psychological/neurological effects were also detected during acute or chronic use, but aminoquinolines do not cross the placenta easily and low quantity is found in breast milk despite their long mean residence times, which depends on the coexistence of hepatic diseases (cancer-related or not), first pass metabolism, and comedications. 'e low cost and availability on the world market have converted aminoquinolines into “star drugs” for pharmaceutical repurposing, but a continuous pharmacovigilance is necessary because these antimalarials have multiple modes of action/unwanted targets, relatively narrow therapeutic windows, recurrent adverse effects, and related poisoning self-treatment. 'erefore, their use must obey strict rules, ethical and medical prescriptions, and clinical and laboratory monitoringengHindawiAminoquinolinasHidroxicloroquinaAntimaláricosCloroquinaAminoquinolinesHydroxychloroquineAntimalarialsChloroquineAminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Featuresinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83097https://www.arca.fiocruz.br/bitstream/icict/49085/1/license.txt36b51ef91c52b5338d9d29ba0cc807bcMD51ORIGINALFerreira, Paulo Michel Pinheiro Aminoquinolines..pdfFerreira, Paulo Michel Pinheiro 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dc.title.pt_BR.fl_str_mv Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
title Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
spellingShingle Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
Ferreira, Paulo Michel Pinheiro
Aminoquinolinas
Hidroxicloroquina
Antimaláricos
Cloroquina
Aminoquinolines
Hydroxychloroquine
Antimalarials
Chloroquine
title_short Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
title_full Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
title_fullStr Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
title_full_unstemmed Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
title_sort Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features
author Ferreira, Paulo Michel Pinheiro
author_facet Ferreira, Paulo Michel Pinheiro
Ferreira, José Roberto de Oliveira
Sousa, Rayran Walter Ramos de
Bezerra, Daniel Pereira
Militão, Gardenia Carmen Gadelha
author_role author
author2 Ferreira, José Roberto de Oliveira
Sousa, Rayran Walter Ramos de
Bezerra, Daniel Pereira
Militão, Gardenia Carmen Gadelha
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Paulo Michel Pinheiro
Ferreira, José Roberto de Oliveira
Sousa, Rayran Walter Ramos de
Bezerra, Daniel Pereira
Militão, Gardenia Carmen Gadelha
dc.subject.other.pt_BR.fl_str_mv Aminoquinolinas
Hidroxicloroquina
Antimaláricos
Cloroquina
topic Aminoquinolinas
Hidroxicloroquina
Antimaláricos
Cloroquina
Aminoquinolines
Hydroxychloroquine
Antimalarials
Chloroquine
dc.subject.en.pt_BR.fl_str_mv Aminoquinolines
Hydroxychloroquine
Antimalarials
Chloroquine
description “Conselho Nacional de Desenvolvimento Cient´ıfico e Tecnol´ogico” (CNPq) for their personal scholarships (303247/2019-3 and 313350/2018-3, respectively).
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-09-15T19:02:02Z
dc.date.available.fl_str_mv 2021-09-15T19:02:02Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Paulo Michel Pinheiro et al. Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features. Journal of Oncology, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49085
dc.identifier.issn.pt_BR.fl_str_mv 1687-8450
dc.identifier.doi.none.fl_str_mv /10.1155/2021/3569349
identifier_str_mv FERREIRA, Paulo Michel Pinheiro et al. Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features. Journal of Oncology, 2021.
1687-8450
/10.1155/2021/3569349
url https://www.arca.fiocruz.br/handle/icict/49085
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/49085/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/49085/2/Ferreira%2c%20Paulo%20Michel%20Pinheiro%20Aminoquinolines..pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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