H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15805 |
Resumo: | Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Oliveira, Marília SantiniCamacho, Luiz A. B.Souza, Thiago M. L.Luz, Paula M.Vasconcellos, Mauricio T. L.Gripp, Carmem B. W. GiacoiaMorgado, Mariza G.Nunes, Estevão P.Lemos, Alberto S.Ferreira, Ana C. G.Moreira, Ronaldo I.Veloso, Valdiléa G.Siqueira, Marilda Agudo Mendonça Teixeira deGrinsztejn, Beatriz2016-09-15T12:54:19Z2016-09-15T12:54:19Z2012OLIVEIRA, Marilia Santini et al. H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses. Plos One, v. 7, n. 6, p. 1-11, June 2012.1932-6203https://www.arca.fiocruz.br/handle/icict/1580510.1371/journal.pone.0039310engPublic Library of ScienceInfecções por HIVVacinaçãoResposta imunológicaPandemia de gripe AHIV-Infected AdultsVaccinationPandemic influenza A (H1N1pdm09)Immune responseH1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Dosesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Viroses Respiratórias. NIC-WHO. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Viroses Respiratórias. NIC-WHO. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.Background: Since human immunodeficiency virus (HIV)-infected individuals are at increased risk of severe disease from pandemic influenza A (H1N1pdm09), vaccination was recommended as a prevention strategy. The aim of the present study was to evaluate the safety, immunogenicity and persistence of the immune response after vaccination against pandemic influenza A (H1N1pdm09) with an adjuvanted vaccine in human immunodeficiency virus (HIV)-infected adults using two single and two double doses. Methodology/Principal Findings: Open label, randomized trial to evaluate the immune response following H1N1pdm09 vaccination in HIV-infected participants compared to HIV-negative controls (NCT01155037). HIV-infected participants were randomized to receive 2 single (3.75 mg hemagglutinin) or 2 double (7.5 mg hemagglutinin) doses of the vaccine, 21 days apart. Controls received one dose of the vaccine. The primary endpoint was seroconversion as measured by hemagglutination inhibition assay. Two hundred fifty six HIV-infected participants (129 and 127 randomized to single and double doses, respectively) and 71 HIV-negative controls were enrolled. Among HIV-infected participants, seroconversion increased from 46.7% and 51.7% after the first dose to 77.2% and 83.8% after the second dose of the vaccine using single and double doses, respectively. Participants aged .40 years showed higher seroconversion compared to younger participants. Seroconversion among HIV-infected women and those with nadir CD4,200 cells/mm3 was significantly higher with double doses. Persistence of protective antibodies six months after vaccination was achieved by 80% and 89.9% of the HIV-infected participants who received single and double doses, respectively. Conclusions/Significance: Our results support the recommendation of two double doses of adjuvanted H1N1pdm09 vaccine for HIV-infected individuals, particularly women, and those aged .40 years or with nadir CD4,200 cells/mm3, to achieve antibody levels that are both higher and more sustained.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15805/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALcarmem_gripp_etal_IOC_2012.pdfcarmem_gripp_etal_IOC_2012.pdfapplication/pdf556933https://www.arca.fiocruz.br/bitstream/icict/15805/2/carmem_gripp_etal_IOC_2012.pdf3fadf07d99ea23b8de4ef99dec5fb2dfMD52TEXTcarmem_gripp_etal_IOC_2012.pdf.txtcarmem_gripp_etal_IOC_2012.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses |
| title |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses |
| spellingShingle |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses Oliveira, Marília Santini Infecções por HIV Vacinação Resposta imunológica Pandemia de gripe A HIV-Infected Adults Vaccination Pandemic influenza A (H1N1pdm09) Immune response |
| title_short |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses |
| title_full |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses |
| title_fullStr |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses |
| title_full_unstemmed |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses |
| title_sort |
H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses |
| author |
Oliveira, Marília Santini |
| author_facet |
Oliveira, Marília Santini Camacho, Luiz A. B. Souza, Thiago M. L. Luz, Paula M. Vasconcellos, Mauricio T. L. Gripp, Carmem B. W. Giacoia Morgado, Mariza G. Nunes, Estevão P. Lemos, Alberto S. Ferreira, Ana C. G. Moreira, Ronaldo I. Veloso, Valdiléa G. Siqueira, Marilda Agudo Mendonça Teixeira de Grinsztejn, Beatriz |
| author_role |
author |
| author2 |
Camacho, Luiz A. B. Souza, Thiago M. L. Luz, Paula M. Vasconcellos, Mauricio T. L. Gripp, Carmem B. W. Giacoia Morgado, Mariza G. Nunes, Estevão P. Lemos, Alberto S. Ferreira, Ana C. G. Moreira, Ronaldo I. Veloso, Valdiléa G. Siqueira, Marilda Agudo Mendonça Teixeira de Grinsztejn, Beatriz |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Marília Santini Camacho, Luiz A. B. Souza, Thiago M. L. Luz, Paula M. Vasconcellos, Mauricio T. L. Gripp, Carmem B. W. Giacoia Morgado, Mariza G. Nunes, Estevão P. Lemos, Alberto S. Ferreira, Ana C. G. Moreira, Ronaldo I. Veloso, Valdiléa G. Siqueira, Marilda Agudo Mendonça Teixeira de Grinsztejn, Beatriz |
| dc.subject.other.pt_BR.fl_str_mv |
Infecções por HIV Vacinação Resposta imunológica Pandemia de gripe A |
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Infecções por HIV Vacinação Resposta imunológica Pandemia de gripe A HIV-Infected Adults Vaccination Pandemic influenza A (H1N1pdm09) Immune response |
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HIV-Infected Adults Vaccination Pandemic influenza A (H1N1pdm09) Immune response |
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Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2012 |
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2012 |
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2016-09-15T12:54:19Z |
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2016-09-15T12:54:19Z |
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OLIVEIRA, Marilia Santini et al. H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses. Plos One, v. 7, n. 6, p. 1-11, June 2012. |
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https://www.arca.fiocruz.br/handle/icict/15805 |
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1932-6203 |
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10.1371/journal.pone.0039310 |
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OLIVEIRA, Marilia Santini et al. H1N1pdm09 Adjuvanted Vaccination in HIV-Infected Adults: A Randomized Trial of Two Single versus Two Double Doses. Plos One, v. 7, n. 6, p. 1-11, June 2012. 1932-6203 10.1371/journal.pone.0039310 |
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