Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/37525 |
Resumo: | 2020-06-02 |
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Brito, R. C.Mello, F. C. Q.Andrade, M. K.Oliveira, H.Costa, W.Matos, H. J.Lourenço, M. C.Rolla, V. C.Fonseca, L.Ruffino Netto, A.Kritski, A. L.2019-12-02T15:00:44Z2019-12-02T15:00:44Z2010BRITO, R. C. et al. Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease, v. 14, n. 1, p. 24-33, 2010.1027-3719https://www.arca.fiocruz.br/handle/icict/375251815-7920engInternational Union Against Tuberculosis and Lung DiseaseDrug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-06-02Secretaria de Estado de Saúde e Defesa Civil do Rio de Janeiro. Programa de Controle da Tuberculose. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil / Secretaria Municipal de Saúde da Prefeitura do Rio de Janeiro. Hospital Raphael de Paula Souza. Rio de Janeiro, RJ, Brasil.Secretaria de Estado de Saúde e Defesa Civil do Rio de Janeiro. Hospital Estadual Santa Maria. Rio de Janeiro, RJ, Brasil.Secretaria de Estado de Saúde e Defesa Civil do Rio de Janeiro. Instituto Estadual de Doenças do Tórax Ary Parreiras. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Hospital dos Servidores do Estado. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil / Secretaria Municipal de Saúde da Prefeitura do Rio de Janeiro. Hospital Raphael de Paula Souza. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Ribeirão Preto, SP, Brasil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brasil / Secretaria Municipal de Saúde da Prefeitura do Rio de Janeiro. Hospital Raphael de Paula Souza. Rio de Janeiro, RJ, Brasil.SETTING: Tuberculosis (TB) drug resistance survey in six hospitals in Rio de Janeiro, Brazil. OBJECTIVE: To estimate resistance to at least one drug (DR) and multidrug resistance (MDR) and identify associated factors. DESIGN: One-year cross-sectional survey. Hospitals were included as a convenience sample. RESULTS: Of 595 patients investigated, 156 (26.2%) had previously undergone anti-tuberculosis treatment, 433 (72.8%) were not previously treated and information on the remaining 6 was not available. Overall, DR and MDR rates were high, at respectively 102 (17.1%, 95%CI 14.3–20.5) and 44 (7.4%, 95%CI 5.5–9.9) cases. Among individuals not previously treated, 17 had MDR (3.9%, 95%CI 2.4–6.3) and diagnosis in a TB reference hospital was independently associated with MDR (prevalence ratio [PR] 3.3, 95%CI 1.2–8.7) after multivariate analysis. Among previously treated individuals, 27 had MDR (17.3%, 95%CI 11.7–24.2). MDR-TB was independently associated with diagnosis in a TB reference hospital (PR 3.6, 95%CI 1.5–8.7), male sex (PR 2.3, 95%CI 1.2–4.4) and dyspnoea (PR 0.3, 95%CI 0.1–0.7). CONCLUSION: We found high levels of DR- and MDRTB. Our study design did not permit us to determine the contribution of community versus nosocomial transmission. Further studies are needed to establish this. Nevertheless, hospitals should be recognised as a potential source of transmission of resistant TB strains and urgent measures to avoid nosocomial TB transmission should be taken.M. tuberculosisDrug resistanceMDR-TBEpidemiologyHospitalsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/37525/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Brito_R_etal_INI_2010.pdfve_Brito_R_etal_INI_2010.pdfapplication/pdf270454https://www.arca.fiocruz.br/bitstream/icict/37525/2/ve_Brito_R_etal_INI_2010.pdfabff965f129e4e308a600924c70b862cMD52TEXTve_Brito_R_etal_INI_2010.pdf.txtve_Brito_R_etal_INI_2010.pdf.txtExtracted texttext/plain47941https://www.arca.fiocruz.br/bitstream/icict/37525/3/ve_Brito_R_etal_INI_2010.pdf.txt6857568d68b3e555a35fabb4d1f3b6a1MD53icict/375252021-03-24 16:32:32.654oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:32Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
| title |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
| spellingShingle |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil Brito, R. C. M. tuberculosis Drug resistance MDR-TB Epidemiology Hospitals |
| title_short |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
| title_full |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
| title_fullStr |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
| title_full_unstemmed |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
| title_sort |
Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil |
| author |
Brito, R. C. |
| author_facet |
Brito, R. C. Mello, F. C. Q. Andrade, M. K. Oliveira, H. Costa, W. Matos, H. J. Lourenço, M. C. Rolla, V. C. Fonseca, L. Ruffino Netto, A. Kritski, A. L. |
| author_role |
author |
| author2 |
Mello, F. C. Q. Andrade, M. K. Oliveira, H. Costa, W. Matos, H. J. Lourenço, M. C. Rolla, V. C. Fonseca, L. Ruffino Netto, A. Kritski, A. L. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Brito, R. C. Mello, F. C. Q. Andrade, M. K. Oliveira, H. Costa, W. Matos, H. J. Lourenço, M. C. Rolla, V. C. Fonseca, L. Ruffino Netto, A. Kritski, A. L. |
| dc.subject.en.pt_BR.fl_str_mv |
M. tuberculosis Drug resistance MDR-TB Epidemiology Hospitals |
| topic |
M. tuberculosis Drug resistance MDR-TB Epidemiology Hospitals |
| description |
2020-06-02 |
| publishDate |
2010 |
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2010 |
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2019-12-02T15:00:44Z |
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2019-12-02T15:00:44Z |
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info:eu-repo/semantics/publishedVersion |
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BRITO, R. C. et al. Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease, v. 14, n. 1, p. 24-33, 2010. |
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https://www.arca.fiocruz.br/handle/icict/37525 |
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1815-7920 |
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BRITO, R. C. et al. Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil. International Journal of Tuberculosis and Lung Disease, v. 14, n. 1, p. 24-33, 2010. 1027-3719 1815-7920 |
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International Union Against Tuberculosis and Lung Disease |
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International Union Against Tuberculosis and Lung Disease |
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