ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil

Detalhes bibliográficos
Autor(a) principal: Gonçalves, Marilda de Souza
Data de Publicação: 2003
Outros Autores: Bomfim, Gilberto Cafezeiro, Maciel, Elves Anderson Pires, Cerqueira, I, Lyra, Isa Menezes, Zanette, Angela Maria Dias, Bomfim, Maria da Glória, Adorno, Elisângela Vitória, Albuquerque, Arlete Barreto Lins de, Pontes, A, Dupuit, M. F, Fernandes, Gilenio Borges, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/20425
Resumo: PAPESFIOCRUZ (No. 0250250304) and CNPq (No. 521201/96-1).
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spelling Gonçalves, Marilda de SouzaBomfim, Gilberto CafezeiroMaciel, Elves Anderson PiresCerqueira, ILyra, Isa MenezesZanette, Angela Maria DiasBomfim, Maria da GlóriaAdorno, Elisângela VitóriaAlbuquerque, Arlete Barreto Lins dePontes, ADupuit, M. FFernandes, Gilenio BorgesReis, Mitermayer Galvão dos2017-07-27T17:09:19Z2017-07-27T17:09:19Z2003GONÇALVES, M. S. et al. ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil. Brazilian Journal of Medical and Biological Research, v. 36, n. 10, p. 1283-1288, 2003.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/20425PAPESFIOCRUZ (No. 0250250304) and CNPq (No. 521201/96-1).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Faculdade de Farmácia. Laboratório de Biologia Molecular. Departamento de Toxicologia e Análises Clínicas. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilSecretaria de Saúde da Bahia. Fundação Hemocentro da Bahia. Salvador, BA, BrasilSecretaria de Saúde da Bahia. Fundação Hemocentro da Bahia. Salvador, BA, BrasilHospitalar Professor Edgard Santos. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFaculdade de Farmácia. Laboratório de Biologia Molecular. Departamento de Toxicologia e Análises Clínicas. Salvador, BA, BrasilFaculdade de Farmácia. Laboratório de Biologia Molecular. Departamento de Toxicologia e Análises Clínicas. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Matemática. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilßS-Globin haplotypes were studied in 80 (160 ßS chromosomes) sickle cell disease patients from Salvador, Brazil, a city with a large population of African origin resulting from the slave trade from Western Africa, mainly from the Bay of Benin. Hematological and hemoglobin analyses were carried out by standard methods. The ßS-haplotypes were determined by PCR and dot-blot techniques. A total of 77 (48.1%) chromosomes were characterized as Central African Republic (CAR) haplotype, 73 (45.6%) as Benin (BEN), 1 (0.63%) as Senegal (SEN), and 9 (5.63%) as atypical (Atp). Genotype was CAR/ CAR in 17 (21.3%) patients, BEN/BEN in 17 (21.3%), CAR/BEN in 37 (46.3%), BEN/SEN in 1 (1.25%), BEN/Atp in 1 (1.25%), CAR/Atp in 6 (7.5%), and Atp/Atp in 1 (1.25%). Hemoglobin concentrations and hematocrit values did not differ among genotype groups but were significantly higher in 25 patients presenting percent fetal hemoglobin (%HbF) ≥10% (P = 0.002 and 0.003, respectively). The median HbF concentration was 7.54 ± 4.342% for the CAR/CAR genotype, 9.88 ± 3.558% for the BEN/BEN genotype, 8.146 ± 4.631% for the CAR/ BEN genotype, and 4.180 ± 2.250% for the CAR/Atp genotype (P = 0.02), although 1 CAR/CAR individual presented an HbF concentration as high as 15%. In view of the ethnic and geographical origin of this population, we did not expect a Hardy-Weinberg equilibrium for CAR/CAR and BEN/BEN homozygous haplotypes and a high proportion of heterozygous CAR/BEN haplotypes since the State of Bahia historically received more slaves from Western Africa than from Central Africa.engFaculdade de Medicina de Ribeirao Preto. Associação Brasileira de DivulgaçãoBeta (S) plantastiposHemoglobina fetalAnemia falciformeHemoglobina SPopulação brasileiraBeta(S)-haplotypesFetal hemoglobinSickle cell anemiaS hemoglobinBrazilian populationßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20425/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGonçalves MS BS Haplotypes in sickle....pdfGonçalves MS BS Haplotypes in sickle....pdfapplication/pdf585067https://www.arca.fiocruz.br/bitstream/icict/20425/2/Gon%c3%a7alves%20MS%20BS%20Haplotypes%20in%20sickle....pdfcb0d25b2f356bbb59ad509d85a02d8a8MD52TEXTGonçalves MS BS Haplotypes in sickle....pdf.txtGonçalves MS BS Haplotypes 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dc.title.pt_BR.fl_str_mv ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
title ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
spellingShingle ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
Gonçalves, Marilda de Souza
Beta (S) plantastipos
Hemoglobina fetal
Anemia falciforme
Hemoglobina S
População brasileira
Beta(S)-haplotypes
Fetal hemoglobin
Sickle cell anemia
S hemoglobin
Brazilian population
title_short ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
title_full ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
title_fullStr ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
title_full_unstemmed ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
title_sort ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil
author Gonçalves, Marilda de Souza
author_facet Gonçalves, Marilda de Souza
Bomfim, Gilberto Cafezeiro
Maciel, Elves Anderson Pires
Cerqueira, I
Lyra, Isa Menezes
Zanette, Angela Maria Dias
Bomfim, Maria da Glória
Adorno, Elisângela Vitória
Albuquerque, Arlete Barreto Lins de
Pontes, A
Dupuit, M. F
Fernandes, Gilenio Borges
Reis, Mitermayer Galvão dos
author_role author
author2 Bomfim, Gilberto Cafezeiro
Maciel, Elves Anderson Pires
Cerqueira, I
Lyra, Isa Menezes
Zanette, Angela Maria Dias
Bomfim, Maria da Glória
Adorno, Elisângela Vitória
Albuquerque, Arlete Barreto Lins de
Pontes, A
Dupuit, M. F
Fernandes, Gilenio Borges
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gonçalves, Marilda de Souza
Bomfim, Gilberto Cafezeiro
Maciel, Elves Anderson Pires
Cerqueira, I
Lyra, Isa Menezes
Zanette, Angela Maria Dias
Bomfim, Maria da Glória
Adorno, Elisângela Vitória
Albuquerque, Arlete Barreto Lins de
Pontes, A
Dupuit, M. F
Fernandes, Gilenio Borges
Reis, Mitermayer Galvão dos
dc.subject.other.pt_BR.fl_str_mv Beta (S) plantastipos
Hemoglobina fetal
Anemia falciforme
Hemoglobina S
População brasileira
topic Beta (S) plantastipos
Hemoglobina fetal
Anemia falciforme
Hemoglobina S
População brasileira
Beta(S)-haplotypes
Fetal hemoglobin
Sickle cell anemia
S hemoglobin
Brazilian population
dc.subject.en.pt_BR.fl_str_mv Beta(S)-haplotypes
Fetal hemoglobin
Sickle cell anemia
S hemoglobin
Brazilian population
description PAPESFIOCRUZ (No. 0250250304) and CNPq (No. 521201/96-1).
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2017-07-27T17:09:19Z
dc.date.available.fl_str_mv 2017-07-27T17:09:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GONÇALVES, M. S. et al. ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil. Brazilian Journal of Medical and Biological Research, v. 36, n. 10, p. 1283-1288, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/20425
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
identifier_str_mv GONÇALVES, M. S. et al. ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil. Brazilian Journal of Medical and Biological Research, v. 36, n. 10, p. 1283-1288, 2003.
0100-879X
url https://www.arca.fiocruz.br/handle/icict/20425
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Faculdade de Medicina de Ribeirao Preto. Associação Brasileira de Divulgação
publisher.none.fl_str_mv Faculdade de Medicina de Ribeirao Preto. Associação Brasileira de Divulgação
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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