High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection

Detalhes bibliográficos
Autor(a) principal: Oliveira, André L. A.
Data de Publicação: 2009
Outros Autores: Hayakawa, Hitoshi, Schor, Doris, Leite, Ana Claudia C. B., Espíndola, Otávio M., Waters, Allison, Dean, Jonathan, Doherty, Derek G., Araújo, Abelardo Q.-C., Hall, William W.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/39054
Resumo: 2021-01-08
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spelling Oliveira, André L. A.Hayakawa, HitoshiSchor, DorisLeite, Ana Claudia C. B.Espíndola, Otávio M.Waters, AllisonDean, JonathanDoherty, Derek G.Araújo, Abelardo Q.-C.Hall, William W.2020-01-08T12:32:43Z2020-01-08T12:32:43Z2009OLIVEIRA, André L. A. et al. High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection. Journal of Immunology, v. 183, p. 2957-2965, 2009.0022-1767https://www.arca.fiocruz.br/handle/icict/3905410.4049/jimmunol.09005081550-6606engAmerican Association of ImmunologistsHigh frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2021-01-08University College Dublin. Centre for Research in Infectious Diseases. Dublin, Ireland.University College Dublin. Centre for Research in Infectious Diseases. Dublin, Ireland.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa em Patogenia Viral. Rio de Janeiro, RJ, Brasil.University College Dublin. National Virus Reference Laboratory. Dublin, Ireland.University College Dublin. Centre for Research in Infectious Diseases. Dublin, Ireland.National University of Ireland. Department of Biology. Cellular Immunology Laboratory. Maynooth, Ireland / Trinity College Dublin. St. James’s Hospital Department of Immunology. Dublin, Ireland.University College Dublin. Centre for Research in Infectious Diseases. Dublin, Ireland / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Laboratório de Pesquisa em Neuroinfecções. Rio de Janeiro, RJ, Brasil.University College Dublin. Centre for Research in Infectious Diseases. Dublin, Ireland / University College Dublin. National Virus Reference Laboratory. Dublin, Ireland.Human T lymphotropic virus type 2 (HTLV-2) is characterized by a clinically asymptomatic persistent infection in the vast majority of infected individuals. In this study, we have characterized for the first time ex vivo specific CTL responses against the HTLV-2 Tax protein. We could detect CTL responses only against a single HLA-A*0201-restricted Tax2 epitope, comprising residues 11–19 (LLYGYPVYV), among three alleles screened. Virus-specific CTLs could be detected in most evaluated subjects, with frequencies as high as 24% of circulating CD8 T cells. The frequency of specific CTLs had a statistically significant positive correlation with proviral load levels. The majority of virus-specific CD8 T cells exhibited an effector memory/terminally differentiated phenotype, expressed high levels of cytotoxicity mediators, including perforin and granzyme B, and lysed in vitro target cells pulsed with Tax2 (11–19) synthetic peptide in a dose-dependent manner. Our findings suggest that a strong, effective CTL response may control HTLV-2 viral burden and that this may be a significant factor in maintaining persistent infection and in the prevention of disease in infected individuals.HTLV-2CD8+ T cellsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/39054/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Oliveira_André_etal_INI_2009.pdfve_Oliveira_André_etal_INI_2009.pdfapplication/pdf2897321https://www.arca.fiocruz.br/bitstream/icict/39054/2/ve_Oliveira_Andr%c3%a9_etal_INI_2009.pdf652d1b4f3a61b6b22e454d0be83079efMD52TEXTve_Oliveira_André_etal_INI_2009.pdf.txtve_Oliveira_André_etal_INI_2009.pdf.txtExtracted texttext/plain55161https://www.arca.fiocruz.br/bitstream/icict/39054/3/ve_Oliveira_Andr%c3%a9_etal_INI_2009.pdf.txt95af29e27964340da0c7217e88611ed5MD53icict/390542021-03-24 16:32:42.286oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
title High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
spellingShingle High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
Oliveira, André L. A.
HTLV-2
CD8+ T cells
title_short High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
title_full High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
title_fullStr High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
title_full_unstemmed High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
title_sort High frequencies of functionally competent circulating tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection
author Oliveira, André L. A.
author_facet Oliveira, André L. A.
Hayakawa, Hitoshi
Schor, Doris
Leite, Ana Claudia C. B.
Espíndola, Otávio M.
Waters, Allison
Dean, Jonathan
Doherty, Derek G.
Araújo, Abelardo Q.-C.
Hall, William W.
author_role author
author2 Hayakawa, Hitoshi
Schor, Doris
Leite, Ana Claudia C. B.
Espíndola, Otávio M.
Waters, Allison
Dean, Jonathan
Doherty, Derek G.
Araújo, Abelardo Q.-C.
Hall, William W.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, André L. A.
Hayakawa, Hitoshi
Schor, Doris
Leite, Ana Claudia C. B.
Espíndola, Otávio M.
Waters, Allison
Dean, Jonathan
Doherty, Derek G.
Araújo, Abelardo Q.-C.
Hall, William W.
dc.subject.en.pt_BR.fl_str_mv HTLV-2
CD8+ T cells
topic HTLV-2
CD8+ T cells
description 2021-01-08
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2020-01-08T12:32:43Z
dc.date.available.fl_str_mv 2020-01-08T12:32:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, André L. A. et al. High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection. Journal of Immunology, v. 183, p. 2957-2965, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/39054
dc.identifier.issn.pt_BR.fl_str_mv 0022-1767
dc.identifier.doi.none.fl_str_mv 10.4049/jimmunol.0900508
dc.identifier.eissn.none.fl_str_mv 1550-6606
identifier_str_mv OLIVEIRA, André L. A. et al. High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection. Journal of Immunology, v. 183, p. 2957-2965, 2009.
0022-1767
10.4049/jimmunol.0900508
1550-6606
url https://www.arca.fiocruz.br/handle/icict/39054
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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