Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study

Detalhes bibliográficos
Autor(a) principal: Araújo-Pereira, Mariana
Data de Publicação: 2023
Outros Autores: Nogueira, Betânia M. F., Spener-Gomes, Renata, Carvalho, Anna C. C., Sant'Anna, Flávia Marinho, Figueiredo, Marina C., Turner, Megan M., Kritski, Afrânio L., Cordeiro-Santos, Marcelo, Rolla, Valeria C., Sterling, Timothy R., Andrade, Bruno B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60236
Resumo: Adriano Gomes-Silva, Francine P. Ignácio. Maria C. Lourenço, Aline Benjamin, Jamile G. de Oliveira, Solange Cavalcante, Betina Durovni - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brazil.
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spelling Araújo-Pereira, MarianaNogueira, Betânia M. F.Spener-Gomes, RenataCarvalho, Anna C. C.Sant'Anna, Flávia MarinhoFigueiredo, Marina C.Turner, Megan M.Kritski, Afrânio L.Cordeiro-Santos, MarceloRolla, Valeria C.Sterling, Timothy R.Andrade, Bruno B.2023-08-26T15:03:26Z2023-08-26T15:03:26Z2023ARAÚJO-PEREIRA, Mariana et al. Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study. Journal of Infection and Public Health, v. 16, n. 6, p. 974-980, June 2023.1876-0341https://www.arca.fiocruz.br/handle/icict/6023610.1016/j.jiph.2023.04.0091876-035XAdriano Gomes-Silva, Francine P. Ignácio. Maria C. Lourenço, Aline Benjamin, Jamile G. de Oliveira, Solange Cavalcante, Betina Durovni - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brazil.Platforms of RePORT-Brazil Consortium: Alice M S Andrade 10, Vanessa Nascimento 11, Juan Manuel Cubillos-Angulo 12, Hayna Malta-Santos 12, Jéssica Rebouças-Silva 13, Saulo R N Santos 11, André Ramos 11, Pedro Brito 14, Carolina A S Schmaltz 5, Alysson G Costa 15, Leandro Sousa Garcia 15, Brenda K de Sousa Carvalho 15, Bruna P de Loiola 15, Adriano Gomes-Silva 5, Francine P Ignácio 5, Maria C Lourenço 5, Elisangela C Silva 16, Mayla Mello 17, Alexandra B Souza 15, Beatriz Barreto-Duarte 10, Michael S Rocha 18, Aline Benjamin 5, Adriana S R Moreira 16, Jamile G de Oliveira 5, Solange Cavalcante 5, Betina Durovni 5, José R Lapa-E-Silva 7The study was supported by the Intramural Research Program of the Fundação Oswaldo Cruz (BBA), Intramural Research Program of the Fundação José Silveira (BBA), Departamento de Ciência e Tecnologia (DECIT) - Secretaria de Ciência e Tecnologia (SCTIE) – Ministério da Saúde (MS), Brazil [25029.000507/2013-07 to V.C.R.], and the National Institutes of Allergy and Infectious Diseases [U01-AI069923 to BMFN, VCR, ALK, TRS, BBA, and MCS and U01-AI115940 to BBA]. MA-P received a fellowship from Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance code: 001). BBA, ALK and VCR are senior investigators from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Brazil. ALK is recipient of the Scientist of our State fellowship from Rio de Janeiro Research Council/FAPERJ. All authors have read and agreed to the submitted version of the manuscript. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brazil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador,BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Universidade FTC. Curso de Medicina. Salvador, BA, Brazil.Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brazil / Fundação José Silveira. Instituto Brasileiro para Investigação da Tuberculose. Salvador, BA, Brazil.Fundação Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil / Universidade Federal do Amazonas. Manaus, AM, Brazil.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cru. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ, Brazil.Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, TN, USA.Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, TN, USA.Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Programa Acadêmico de Tuberculose. Rio de Janeiro, RJ, Brazil.Fundação Medicina Tropical Dr Heitor Vieira Dourado. Manaus, AM, Brazil / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brazil / Universidade Nilton Lins. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brazil.Division of Infectious Diseases. Department of Medicine. Vanderbilt University School of Medicine. Nashville, TN, USA.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Inflamação e Biomarcadores. Salvador, BA, Brazil / Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, Brazil; Faculdade de Medicina, Universidade Federal da Bahia, Salvador, BA, Brazil / Universidade FTC. Curso de Medicina. Salvador, BA, Brazil.Background: Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity of anemia in PWTB prior to anti-TB treatment (ATT) was a risk factor for an unfavorable outcome. Methods: Patients ≥ 18 years old with culture-confirmed drug-susceptible pulmonary TB enrolled between 2015 and 2019 in a multi-center Brazilian cohort were followed for up to 24 months and classified according to anemia severity (mild, moderate, and severe), based on hemoglobin levels. A multinomial logistic regression model was employed to assess whether anemia was associated with unfavorable outcome (death, failure, loss to follow-up, regimen modification or relapse), compared to treatment success (cure or treatment completion). Results: Among 786 participants who met inclusion criteria, 441 (56 %) were anemic at baseline. Patients with moderate/severe anemia were more HIV-seropositive, as well as more symptomatic and had higher frequencies of unfavorable outcomes compared to the other groups. Moderate/severe anemia (adjusted OR [aOR]: 7.80, 95 %CI:1.34-45.4, p = 0.022) was associated with death independent of sex, age, BMI, HIV and glycemic status. Conclusion: Moderate/severe anemia prior to ATT was a significant risk factor for death. Such patients should be closely monitored given the high risk of unfavorable ATT outcomes.engElsevierAnemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAnemiaDeathHemoglobinTuberculosisTuberculosis treatment outcomeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60236/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Mariana_Araújo-Pereira_etal_INI_2023.pdfve_Mariana_Araújo-Pereira_etal_INI_2023.pdfapplication/pdf975464https://www.arca.fiocruz.br/bitstream/icict/60236/2/ve_Mariana_Ara%c3%bajo-Pereira_etal_INI_2023.pdff2dbf622c76a430aeeda626639d856e2MD52icict/602362023-08-26 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dc.title.en_US.fl_str_mv Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
title Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
spellingShingle Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
Araújo-Pereira, Mariana
Anemia
Death
Hemoglobin
Tuberculosis
Tuberculosis treatment outcome
title_short Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
title_full Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
title_fullStr Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
title_full_unstemmed Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
title_sort Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study
author Araújo-Pereira, Mariana
author_facet Araújo-Pereira, Mariana
Nogueira, Betânia M. F.
Spener-Gomes, Renata
Carvalho, Anna C. C.
Sant'Anna, Flávia Marinho
Figueiredo, Marina C.
Turner, Megan M.
Kritski, Afrânio L.
Cordeiro-Santos, Marcelo
Rolla, Valeria C.
Sterling, Timothy R.
Andrade, Bruno B.
author_role author
author2 Nogueira, Betânia M. F.
Spener-Gomes, Renata
Carvalho, Anna C. C.
Sant'Anna, Flávia Marinho
Figueiredo, Marina C.
Turner, Megan M.
Kritski, Afrânio L.
Cordeiro-Santos, Marcelo
Rolla, Valeria C.
Sterling, Timothy R.
Andrade, Bruno B.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Araújo-Pereira, Mariana
Nogueira, Betânia M. F.
Spener-Gomes, Renata
Carvalho, Anna C. C.
Sant'Anna, Flávia Marinho
Figueiredo, Marina C.
Turner, Megan M.
Kritski, Afrânio L.
Cordeiro-Santos, Marcelo
Rolla, Valeria C.
Sterling, Timothy R.
Andrade, Bruno B.
dc.subject.en.en_US.fl_str_mv Anemia
Death
Hemoglobin
Tuberculosis
Tuberculosis treatment outcome
topic Anemia
Death
Hemoglobin
Tuberculosis
Tuberculosis treatment outcome
description Adriano Gomes-Silva, Francine P. Ignácio. Maria C. Lourenço, Aline Benjamin, Jamile G. de Oliveira, Solange Cavalcante, Betina Durovni - Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Micobacteriose. Rio de Janeiro, RJ, Brazil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-08-26T15:03:26Z
dc.date.available.fl_str_mv 2023-08-26T15:03:26Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ARAÚJO-PEREIRA, Mariana et al. Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study. Journal of Infection and Public Health, v. 16, n. 6, p. 974-980, June 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60236
dc.identifier.issn.en_US.fl_str_mv 1876-0341
dc.identifier.doi.none.fl_str_mv 10.1016/j.jiph.2023.04.009
dc.identifier.eissn.none.fl_str_mv 1876-035X
identifier_str_mv ARAÚJO-PEREIRA, Mariana et al. Anemia and anti-tuberculosis treatment outcome in persons with pulmonary tuberculosis: A multi-center prospective cohort study. Journal of Infection and Public Health, v. 16, n. 6, p. 974-980, June 2023.
1876-0341
10.1016/j.jiph.2023.04.009
1876-035X
url https://www.arca.fiocruz.br/handle/icict/60236
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60236/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/60236/2/ve_Mariana_Ara%c3%bajo-Pereira_etal_INI_2023.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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