Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort

Detalhes bibliográficos
Autor(a) principal: Saraceni, Valeria
Data de Publicação: 2014
Outros Autores: Cohn, Silvia, Cavalcante, Solange C., Pacheco, Antonio G. F., Moulton, Lawrence H., Chaisson, Richard E., Durovni, Betina, Golub, Jonathan E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/35226
Resumo: Solange C. Cavalcante. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
id CRUZ_603737f300517a6d98637838c8f136ff
oai_identifier_str oai:www.arca.fiocruz.br:icict/35226
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Saraceni, ValeriaCohn, SilviaCavalcante, Solange C.Pacheco, Antonio G. F.Moulton, Lawrence H.Chaisson, Richard E.Durovni, BetinaGolub, Jonathan E.2019-08-30T15:03:37Z2019-08-30T15:03:37Z2014SARACENI, Valeria et al. Prevalent Tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort. Journal of Acquired Immune Deficiency Syndromes, v. 67, n. 1, p. 98-101, Sept. 2014.1525-4135https://www.arca.fiocruz.br/handle/icict/3522610.1097/QAI.00000000000002471944-7884Solange C. Cavalcante. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Rio de Janeiro City Health Secretariat. Rio de Janeiro, RJ, Brazil.Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Baltimore, MD, USA.Rio de Janeiro City Health Secretaria. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Baltimore, MD, USA / Johns Hopkins Bloomberg School of Public Health. Baltimore, MD, USA.Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Baltimore, MD, USA / Johns Hopkins Bloomberg School of Public Health. Baltimore, MD, USA.Rio de Janeiro City Health Secretariat. Rio de Janeiro, RJ, Brazil / Federal University of Rio de Janeiro. RJ, Brazil.Johns Hopkins University School of Medicine. Center for Tuberculosis Research. Baltimore, MD, USA / Johns Hopkins Bloomberg School of Public Health. Baltimore, MD, USA.Background — Although Brazil has model HIV care programs, many patients continue to present late to care. We studied the frequency of tuberculosis (TB) diagnosed at HIV diagnosis in Rio de Janeiro, Brazil, in order to quantify missed opportunities for TB prevention. Methods — People living with HIV (PLHIV) and enrolled in the TB/HIV in Rio (THRio) study between 1 September 2005 and 31 August 2009 were included. Prevalent TB was defined as TB diagnosed within 60 days of HIV diagnosis or HIV diagnosis during TB therapy. Survival was measured from HIV diagnosis. We conducted Kaplan-Meier survival plots and Cox regression analyses. Results — 4,548 newly diagnosed PLHIV were enrolled; 476(10.5%) with prevalent TB. Prevalent TB cases were older, had lower CD4 counts and higher viral loads than those without TB. Median time to receiving highly active antiretroviral therapy (HAART) in prevalent TB cases was 99 days(IQR=58–191) vs. 126 days(IQR=63–301) in those without TB(p=0.021). Among prevalent TB cases, 17% died during follow-up compared to 8% among non-TB cases(p<0.001). After adjustment for sex, age, baseline CD4 and baseline viral load, risk of death remained significantly higher among prevalent TB cases[aHR=1.72(CI 95% 1.19–2.48)]. Conclusions — More than 10% of newly PLHIV in our study presented to care with concurrent active TB disease and thus missed the opportunity for TB preventive therapy. Despite initiating HAART more quickly, these were at significantly greater risk of death. Earlier HIV diagnosis is necessary to provide earlier initiation of HAART and TB preventive therapy to reduce morbidity and mortality in PLHIV.engLippincott, Williams & WilkinsPrevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohortinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleTuberculosisHIVRio de JaneiroBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/35226/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALva_Saraceni_Valeria_etal_INI_2014.pdfva_Saraceni_Valeria_etal_INI_2014.pdfapplication/pdf426987https://www.arca.fiocruz.br/bitstream/icict/35226/2/va_Saraceni_Valeria_etal_INI_2014.pdfb01f38bc98b37c88fafa91373fe102ddMD52TEXTva_Saraceni_Valeria_etal_INI_2014.pdf.txtva_Saraceni_Valeria_etal_INI_2014.pdf.txtExtracted texttext/plain25770https://www.arca.fiocruz.br/bitstream/icict/35226/3/va_Saraceni_Valeria_etal_INI_2014.pdf.txt5c3319509d9b5df3b4cb0f39dbd83b56MD53icict/352262021-02-07 21:29:17.953oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-02-08T00:29:17Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
title Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
spellingShingle Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
Saraceni, Valeria
Tuberculosis
HIV
Rio de Janeiro
Brazil
title_short Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
title_full Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
title_fullStr Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
title_full_unstemmed Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
title_sort Prevalent tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort
author Saraceni, Valeria
author_facet Saraceni, Valeria
Cohn, Silvia
Cavalcante, Solange C.
Pacheco, Antonio G. F.
Moulton, Lawrence H.
Chaisson, Richard E.
Durovni, Betina
Golub, Jonathan E.
author_role author
author2 Cohn, Silvia
Cavalcante, Solange C.
Pacheco, Antonio G. F.
Moulton, Lawrence H.
Chaisson, Richard E.
Durovni, Betina
Golub, Jonathan E.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Saraceni, Valeria
Cohn, Silvia
Cavalcante, Solange C.
Pacheco, Antonio G. F.
Moulton, Lawrence H.
Chaisson, Richard E.
Durovni, Betina
Golub, Jonathan E.
dc.subject.en.pt_BR.fl_str_mv Tuberculosis
HIV
Rio de Janeiro
Brazil
topic Tuberculosis
HIV
Rio de Janeiro
Brazil
description Solange C. Cavalcante. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2019-08-30T15:03:37Z
dc.date.available.fl_str_mv 2019-08-30T15:03:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SARACENI, Valeria et al. Prevalent Tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort. Journal of Acquired Immune Deficiency Syndromes, v. 67, n. 1, p. 98-101, Sept. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/35226
dc.identifier.issn.pt_BR.fl_str_mv 1525-4135
dc.identifier.doi.pt_BR.fl_str_mv 10.1097/QAI.0000000000000247
dc.identifier.eissn.none.fl_str_mv 1944-7884
identifier_str_mv SARACENI, Valeria et al. Prevalent Tuberculosis (TB) at HIV diagnosis in Rio de Janeiro, Brazil: The TB/HIV in Rio (THRio) cohort. Journal of Acquired Immune Deficiency Syndromes, v. 67, n. 1, p. 98-101, Sept. 2014.
1525-4135
10.1097/QAI.0000000000000247
1944-7884
url https://www.arca.fiocruz.br/handle/icict/35226
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins
publisher.none.fl_str_mv Lippincott, Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/35226/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/35226/2/va_Saraceni_Valeria_etal_INI_2014.pdf
https://www.arca.fiocruz.br/bitstream/icict/35226/3/va_Saraceni_Valeria_etal_INI_2014.pdf.txt
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
b01f38bc98b37c88fafa91373fe102dd
5c3319509d9b5df3b4cb0f39dbd83b56
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324701643145216

Registros relacionados