Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083

Detalhes bibliográficos
Autor(a) principal: Mitchell, Kate M.
Data de Publicação: 2023
Outros Autores: Boily, Marie-Claude, Hanscom, Brett, Moore, Mia, Todd, Jeffery, Paz-Bailey, Gabriela, Wejnert, Cyprian, Liu, Albert, Donnell, Deborah J., Grinsztejn, Beatriz, Landovitz, Raphael J., Dimitrov, Dobromir T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58410
Resumo: NIH, MRC.
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spelling Mitchell, Kate M.Boily, Marie-ClaudeHanscom, BrettMoore, MiaTodd, JefferyPaz-Bailey, GabrielaWejnert, CyprianLiu, AlbertDonnell, Deborah J.Grinsztejn, BeatrizLandovitz, Raphael J.Dimitrov, Dobromir T.2023-05-15T23:42:36Z2023-05-15T23:42:36Z2023MITCHELL, Kate M. et al. Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083. Lancet Regional Health. Americas, v. 18, p. 1-13, Jan. 2023.2667-193Xhttps://www.arca.fiocruz.br/handle/icict/5841010.1016/j.lana.2022.1004162667-193XNIH, MRC.MRC Centre for Global Infectious Disease Analysis. School of Public Health. Imperial College London. London, United Kingdom / HIV Prevention Trials Network Modelling Centre. Imperial College London. London, United Kingdom.MRC Centre for Global Infectious Disease Analysis. School of Public Health. Imperial College London. London, United Kingdom / HIV Prevention Trials Network Modelling Centre. Imperial College London. London, United Kingdom.Vaccine and Infectious Disease Division. Fred Hutchinson Cancer Center. Seattle, WA, USA.Vaccine and Infectious Disease Division. Fred Hutchinson Cancer Center. Seattle, WA, USA.Centers for Disease Control and Prevention. Atlanta, GA, USA.Division of Vector-Borne Diseases. Centers for Disease Control and Prevention. San Juan, Puerto Rico.Centers for Disease Control and Prevention. Atlanta, GA, USA.Bridge HIV, Population Health Division. San Francisco Department of Public Health. San Francisco, CA, USA / University of California San Francisco. Department of Medicine. San Francisco, CA, USA.Vaccine and Infectious Disease Division. Fred Hutchinson Cancer Center. Seattle, WA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.University of California Los Angeles. Center for Clinical AIDS Research and Education. Los Angeles, CA, USA / Division of Infectious Diseases. David Geffen School of Medicine at UCLA. Los Angeles, CA, USA.accine and Infectious Disease Division. Fred Hutchinson Cancer Center. Seattle, WA, USA.Background: The HPTN 083 trial demonstrated superiority of HIV pre-exposure prophylaxis (PrEP) containing long-acting injectable cabotegravir (CAB) to daily oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) among men who have sex with men (MSM). We compared the potential population-level impact of TDF/FTC and CAB among MSM in Atlanta, Georgia. Methods: An MSM HIV transmission model was calibrated to Atlanta-specific data on HIV prevalence and PrEP usage (percentage of uninfected MSM on PrEP), assuming only PrEP-indicated MSM used PrEP. CAB effectiveness (efficacy × adherence) of 91% was estimated using data from HPTN 083 and previous TDF/FTC trials. We estimated HIV infections averted over 5/10 years if TDF/FTC use were maintained, or if all TDF/FTC users switched to CAB in January 2022 (vs. no PrEP or continued TDF/FTC use). CAB scenarios with 10%/20% more users were also considered. Progress towards Ending the HIV Epidemic (EHE) goals (75%/90% fewer HIV infections in 2025/2030 vs. 2017) was estimated. Findings: We predicted TDF/FTC at current usage (∼28%) would avert 36.3% of new HIV infections (95% credible interval 25.6-48.7%) among all Atlanta MSM over 2022-2026 vs. no PrEP. Switching to CAB with similar usage may prevent 44.6% (33.2-56.6%) infections vs. no PrEP and 11.9% (5.2-20.2%) infections vs. continued TDF/FTC. Increasing CAB usage 20% could increase the incremental impact over TDF/FTC to 30.0% over 2022-2026, getting ∼60% towards reaching EHE goals (47%/54% fewer infections in 2025/2030). Reaching the 2030 EHE goal would require 93% CAB usage. Interpretation: If CAB effectiveness were like HPTN 083, CAB could prevent more infections than TDF/FTC at similar usage. Increased CAB usage could contribute substantially towards reaching EHE goals, but the usage required to meet EHE goals is unrealistic.engElsevierEstimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCabotegravirHIVInjectable PrEPLong-acting PrEPMSMMathematical modellingMen who have sex with menPre-exposure prophylaxisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
title Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
spellingShingle Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
Mitchell, Kate M.
Cabotegravir
HIV
Injectable PrEP
Long-acting PrEP
MSM
Mathematical modelling
Men who have sex with men
Pre-exposure prophylaxis
title_short Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
title_full Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
title_fullStr Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
title_full_unstemmed Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
title_sort Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083
author Mitchell, Kate M.
author_facet Mitchell, Kate M.
Boily, Marie-Claude
Hanscom, Brett
Moore, Mia
Todd, Jeffery
Paz-Bailey, Gabriela
Wejnert, Cyprian
Liu, Albert
Donnell, Deborah J.
Grinsztejn, Beatriz
Landovitz, Raphael J.
Dimitrov, Dobromir T.
author_role author
author2 Boily, Marie-Claude
Hanscom, Brett
Moore, Mia
Todd, Jeffery
Paz-Bailey, Gabriela
Wejnert, Cyprian
Liu, Albert
Donnell, Deborah J.
Grinsztejn, Beatriz
Landovitz, Raphael J.
Dimitrov, Dobromir T.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mitchell, Kate M.
Boily, Marie-Claude
Hanscom, Brett
Moore, Mia
Todd, Jeffery
Paz-Bailey, Gabriela
Wejnert, Cyprian
Liu, Albert
Donnell, Deborah J.
Grinsztejn, Beatriz
Landovitz, Raphael J.
Dimitrov, Dobromir T.
dc.subject.en.en_US.fl_str_mv Cabotegravir
HIV
Injectable PrEP
Long-acting PrEP
MSM
Mathematical modelling
Men who have sex with men
Pre-exposure prophylaxis
topic Cabotegravir
HIV
Injectable PrEP
Long-acting PrEP
MSM
Mathematical modelling
Men who have sex with men
Pre-exposure prophylaxis
description NIH, MRC.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-05-15T23:42:36Z
dc.date.available.fl_str_mv 2023-05-15T23:42:36Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MITCHELL, Kate M. et al. Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083. Lancet Regional Health. Americas, v. 18, p. 1-13, Jan. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58410
dc.identifier.issn.en_US.fl_str_mv 2667-193X
dc.identifier.doi.none.fl_str_mv 10.1016/j.lana.2022.100416
dc.identifier.eissn.none.fl_str_mv 2667-193X
identifier_str_mv MITCHELL, Kate M. et al. Estimating the impact of HIV PrEP regimens containing long-acting injectable cabotegravir or daily oral tenofovir disoproxil fumarate/emtricitabine among men who have sex with men in the United States: a mathematical modelling study for HPTN 083. Lancet Regional Health. Americas, v. 18, p. 1-13, Jan. 2023.
2667-193X
10.1016/j.lana.2022.100416
url https://www.arca.fiocruz.br/handle/icict/58410
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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