High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs

Detalhes bibliográficos
Autor(a) principal: Oliveira, Willian Klassen
Data de Publicação: 2021
Outros Autores: Ávila, Hugo Leonardo, Tadra, Michelle Zibeti, Cardoso, Rodrigo Luiz, Fadel-Pichet, Cyntia Maria Teles, Souza, Emanuel Maltempi de, Pedrosa, Fábio de Oliveira, Faoro, Helisson
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50407
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Programa de Graduação em Bioinformática. Curitiba, PR, Brasil.
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spelling Oliveira, Willian KlassenÁvila, Hugo LeonardoTadra, Michelle ZibetiCardoso, Rodrigo LuizFadel-Pichet, Cyntia Maria TelesSouza, Emanuel Maltempi dePedrosa, Fábio de OliveiraFaoro, Helisson2021-12-14T14:46:33Z2021-12-14T14:46:33Z2021OLIVEIRA, Willian Klassen et al. High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs. Antibiotics, v.10, n. 1409, p. 1–19, 2021.2079-6382https://www.arca.fiocruz.br/handle/icict/5040710.3390/antibiotics10111409porMDPIHerbaspirillum frisingenseGenômica ComparativaHost-Pathogen InteractionsGenomicsInteracciones Huésped-PatógenoGenómicaInteractions hôte-pathogèneGénomiqueHerbaspirillumInterações Hospedeiro-PatógenoGenômicaHigh genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Programa de Graduação em Bioinformática. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Análises Clínicas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Universidade Federal do Paraná. Departamento de Bioquímica e Biologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Programa de Graduação em Bioinformática. Curitiba, PR, Brasil.The genus Herbaspirillum is widely studied for its ability to associate with grasses and to perform biological nitrogen fixation. However, the bacteria of the Herbaspirillum genus have frequently been isolated from clinical samples. Understanding the genomic characteristics that allow these bacteria to switch environments and become able to colonize human hosts is essential for monitoring emerging pathogens and predicting outbreaks. In this work, we describe the sequencing, assembly, and annotation of the genome of H. frisingense AU14559 isolated from the sputum of patients with cystic fibrosis, and its comparison with the genomes of the uropathogenic strain VT-16–41 and the environmental strains GSF30, BH-1, IAC152, and SG826. The genes responsible for biological nitrogen fixation were absent from all strains except for GSF30. On the other hand, genes encoding virulence and host interaction factors were mostly shared with environmental strains. We also identified a large set of intrinsic antibiotic resistance genes that were shared across all strains. Unlike other strains, in addition to unique genomic islands, AU14559 has a mutation that renders the biosynthesis of rhamnose and its incorporation into the exopolysaccharide unfeasible. These data suggest that H. frisingense has characteristics that provide it with the metabolic diversity needed to infect and colonize human hosts.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/50407/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALantibiotics-10-01409OK.pdfantibiotics-10-01409OK.pdfapplication/pdf3002452https://www.arca.fiocruz.br/bitstream/icict/50407/2/antibiotics-10-01409OK.pdf6c682615e8a22068c8eef38770d63ae0MD52icict/504072021-12-14 11:46:33.324oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-12-14T14:46:33Repositório Institucional da FIOCRUZ (ARCA) - 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dc.title.pt_BR.fl_str_mv High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
title High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
spellingShingle High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
Oliveira, Willian Klassen
Herbaspirillum frisingense
Genômica Comparativa
Host-Pathogen Interactions
Genomics
Interacciones Huésped-Patógeno
Genómica
Interactions hôte-pathogène
Génomique
Herbaspirillum
Interações Hospedeiro-Patógeno
Genômica
title_short High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
title_full High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
title_fullStr High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
title_full_unstemmed High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
title_sort High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs
author Oliveira, Willian Klassen
author_facet Oliveira, Willian Klassen
Ávila, Hugo Leonardo
Tadra, Michelle Zibeti
Cardoso, Rodrigo Luiz
Fadel-Pichet, Cyntia Maria Teles
Souza, Emanuel Maltempi de
Pedrosa, Fábio de Oliveira
Faoro, Helisson
author_role author
author2 Ávila, Hugo Leonardo
Tadra, Michelle Zibeti
Cardoso, Rodrigo Luiz
Fadel-Pichet, Cyntia Maria Teles
Souza, Emanuel Maltempi de
Pedrosa, Fábio de Oliveira
Faoro, Helisson
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira, Willian Klassen
Ávila, Hugo Leonardo
Tadra, Michelle Zibeti
Cardoso, Rodrigo Luiz
Fadel-Pichet, Cyntia Maria Teles
Souza, Emanuel Maltempi de
Pedrosa, Fábio de Oliveira
Faoro, Helisson
dc.subject.other.pt_BR.fl_str_mv Herbaspirillum frisingense
Genômica Comparativa
topic Herbaspirillum frisingense
Genômica Comparativa
Host-Pathogen Interactions
Genomics
Interacciones Huésped-Patógeno
Genómica
Interactions hôte-pathogène
Génomique
Herbaspirillum
Interações Hospedeiro-Patógeno
Genômica
dc.subject.en.pt_BR.fl_str_mv Host-Pathogen Interactions
Genomics
dc.subject.es.pt_BR.fl_str_mv Interacciones Huésped-Patógeno
Genómica
dc.subject.fr.pt_BR.fl_str_mv Interactions hôte-pathogène
Génomique
dc.subject.decs.pt_BR.fl_str_mv Herbaspirillum
Interações Hospedeiro-Patógeno
Genômica
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Ciências e Tecnologias Aplicadas em Saúde. Curitiba, PR, Brasil. / Universidade Federal do Paraná. Programa de Graduação em Bioinformática. Curitiba, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-12-14T14:46:33Z
dc.date.available.fl_str_mv 2021-12-14T14:46:33Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Willian Klassen et al. High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs. Antibiotics, v.10, n. 1409, p. 1–19, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50407
dc.identifier.issn.pt_BR.fl_str_mv 2079-6382
dc.identifier.doi.none.fl_str_mv 10.3390/antibiotics10111409
identifier_str_mv OLIVEIRA, Willian Klassen et al. High genomic identity between clinical and environmental strains of Herbaspirillum frisingense suggests pre-adaptation to different hosts and intrinsic resistance to multiple drugs. Antibiotics, v.10, n. 1409, p. 1–19, 2021.
2079-6382
10.3390/antibiotics10111409
url https://www.arca.fiocruz.br/handle/icict/50407
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50407/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50407/2/antibiotics-10-01409OK.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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