Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/28620 |
Resumo: | Fundação de Amparo a Pesquisa de São Paulo número de concessão 2008 / 57608-2 |
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Lima, Emerson de AndradeLima, Mariana de AndradeLorena, Virgínia M. Barros deGomes, Yara de MirandaLupi, OmarBenard, Gil2018-09-11T11:45:04Z2018-09-11T11:45:04Z2011DE ANDRADE LIMA, E. et al. Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting. Acta Dermato-Venereologica, v. 91, n. 6, p. 694–697, out. 2011.1651-2057https://www.arca.fiocruz.br/handle/icict/2862010.2340/00015555-1151Fundação de Amparo a Pesquisa de São Paulo número de concessão 2008 / 57608-2Universidade Federal do Estado de Pernambuco. Hospital das Clínicas. Serviço ambulatorial de psoríase. Recife, PE, Brasil.Universidade Federal do Estado de Pernambuco. Hospital das Clínicas. Serviço ambulatorial de psoríase. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil.Universidade Federal do Estado do Rio de Janeiro. Departamento de Dermatologia. Rio de Janeiro, RJ, Brazil.Universidade de São Paulo. Instituto de Medicina Tropical. Laboratório da Unidade de Investigação Médica 53. São Paulo, SP, Brazil / Universidade de São Paulo. Divisão de Clínica Dermatológica da Faculdade de Medicina. Laboratório de Unidade de Investigação Médica 56. São Paulo, SP, Brazil.Screening for latent tuberculosis infection is mandatory before starting anti-tumour necrosis factor treatments, but its diagnosis still poses a challenge. While studies performed in developed countries have demonstrated superior performance of T-cell based interferon-γ release assay (IGRA) compared with the tuberculin skin test, there is a debate about whether this holds true in tuberculosis endemic areas. The performance of an IGRA kit T-SPOT.TB was evaluated in 33 moderate-to-severe untreated psoriasis patients and, as controls, 30 patients with common dermatological diseases at a tuberculosis highly endemic setting. The frequency of positive tuberculin skin test responses and induration size in controls were higher than in psoriasis patients (53% vs. 18% and 9.3 ± 1.4 vs. 2.6 ± 0.7 mm, respectively, p < 0.001). In contrast, the frequency of positive response and mean number of spots elicited with the T-SPOT.TB test were not significantly different between patients and controls (47% vs. 43% and 14.7 ± 3.2 vs. 20.5 ± 3.1 spots/well, respectively). The two tests presented good agreement in the control, but not the psoriasis group (κ values of 0.625 and 0.375, respectively). Thus, in a highly tuberculosis-endemic setting the T-SPOT.TB test was superior to the tuberculin skin test in diagnosing latent tuberculosis infection in psoriasis, probably because the immune dysregulation of psoriasis shows a lower interference in the in vitro test.engTuberculose LatentePsoríaseFatores de Necrose TumoralTeste em pele tuberculinaEnsaio de libertação de interferão-gama;ELISPOTLatent tuberculosis infectionPsoriasisTNFtuberculin skin testInterferon-γ release assayELISPOTAntígenos Bacterianos / imunologiaProteínas Bacterianas / imunologiaBrasilEstudos TransversaisTestes de Liberação de Interferon-gamaTuberculose latente / complicaçõesTuberculose Latente / diagnósticoTuberculose Latente / imunologiaMycobacterium tuberculosis / imunologiaPsoríase / complicaçõesEvaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic settinginfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83092https://www.arca.fiocruz.br/bitstream/icict/28620/1/license.txt447f2497af1ef5cf99b5c07f6fa18dceMD51ORIGINAL3491.pdf3491.pdfapplication/pdf531952https://www.arca.fiocruz.br/bitstream/icict/28620/2/3491.pdfc671e8409c84046c8da255fb40416a74MD52TEXT3491.pdf.txt3491.pdf.txtExtracted texttext/plain22044https://www.arca.fiocruz.br/bitstream/icict/28620/3/3491.pdf.txt6895eca03e3e43fade71422adc9fc34aMD53icict/286202018-09-12 02:01:21.047oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-09-12T05:01:21Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting |
| title |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting |
| spellingShingle |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting Lima, Emerson de Andrade Tuberculose Latente Psoríase Fatores de Necrose Tumoral Teste em pele tuberculina Ensaio de libertação de interferão-gama; ELISPOT Latent tuberculosis infection Psoriasis TNF tuberculin skin test Interferon-γ release assay ELISPOT Antígenos Bacterianos / imunologia Proteínas Bacterianas / imunologia Brasil Estudos Transversais Testes de Liberação de Interferon-gama Tuberculose latente / complicações Tuberculose Latente / diagnóstico Tuberculose Latente / imunologia Mycobacterium tuberculosis / imunologia Psoríase / complicações |
| title_short |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting |
| title_full |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting |
| title_fullStr |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting |
| title_full_unstemmed |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting |
| title_sort |
Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting |
| author |
Lima, Emerson de Andrade |
| author_facet |
Lima, Emerson de Andrade Lima, Mariana de Andrade Lorena, Virgínia M. Barros de Gomes, Yara de Miranda Lupi, Omar Benard, Gil |
| author_role |
author |
| author2 |
Lima, Mariana de Andrade Lorena, Virgínia M. Barros de Gomes, Yara de Miranda Lupi, Omar Benard, Gil |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Emerson de Andrade Lima, Mariana de Andrade Lorena, Virgínia M. Barros de Gomes, Yara de Miranda Lupi, Omar Benard, Gil |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Latente Psoríase Fatores de Necrose Tumoral Teste em pele tuberculina Ensaio de libertação de interferão-gama; ELISPOT |
| topic |
Tuberculose Latente Psoríase Fatores de Necrose Tumoral Teste em pele tuberculina Ensaio de libertação de interferão-gama; ELISPOT Latent tuberculosis infection Psoriasis TNF tuberculin skin test Interferon-γ release assay ELISPOT Antígenos Bacterianos / imunologia Proteínas Bacterianas / imunologia Brasil Estudos Transversais Testes de Liberação de Interferon-gama Tuberculose latente / complicações Tuberculose Latente / diagnóstico Tuberculose Latente / imunologia Mycobacterium tuberculosis / imunologia Psoríase / complicações |
| dc.subject.en.pt_BR.fl_str_mv |
Latent tuberculosis infection Psoriasis TNF tuberculin skin test Interferon-γ release assay ELISPOT |
| dc.subject.decs.pt_BR.fl_str_mv |
Antígenos Bacterianos / imunologia Proteínas Bacterianas / imunologia Brasil Estudos Transversais Testes de Liberação de Interferon-gama Tuberculose latente / complicações Tuberculose Latente / diagnóstico Tuberculose Latente / imunologia Mycobacterium tuberculosis / imunologia Psoríase / complicações |
| description |
Fundação de Amparo a Pesquisa de São Paulo número de concessão 2008 / 57608-2 |
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2011 |
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2011 |
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2018-09-11T11:45:04Z |
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2018-09-11T11:45:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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DE ANDRADE LIMA, E. et al. Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting. Acta Dermato-Venereologica, v. 91, n. 6, p. 694–697, out. 2011. |
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https://www.arca.fiocruz.br/handle/icict/28620 |
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1651-2057 |
| dc.identifier.doi.none.fl_str_mv |
10.2340/00015555-1151 |
| identifier_str_mv |
DE ANDRADE LIMA, E. et al. Evaluation of an IFN-gamma assay in the diagnosis of latent tuberculosis in patients with psoriasis in a highly endemic setting. Acta Dermato-Venereologica, v. 91, n. 6, p. 694–697, out. 2011. 1651-2057 10.2340/00015555-1151 |
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https://www.arca.fiocruz.br/handle/icict/28620 |
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eng |
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